DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir75d and GRIN2A

DIOPT Version :9

Sequence 1:	NP_649074.2	Gene:	Ir75d / 40065	FlyBaseID:	FBgn0036829	Length:	675	Species:	Drosophila melanogaster
Sequence 2:	XP_016878661.1	Gene:	GRIN2A / 2903	HGNCID:	4585	Length:	1516	Species:	Homo sapiens

Alignment Length:	727	Identity:	136/727 - (18%)
Similarity:	255/727 - (35%)	Gaps:	201/727 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 WQHFNL--------NNF--YVQVSTESSL--RDLQHVDALD-EHKDAPPP---KSFHANNSTHWE 128
            |..|:|        ..|  :|:.:.::|.  .|:|:|..|| ..:||...   |..|::
Human   219 WHVFSLVTTIFPGYREFISFVKTTVDNSFVGWDMQNVITLDTSFEDAKTQVQLKKIHSS------ 277

  Fly   129 TSFLLPALPYKMGILLLEFSSECALNLLRWSAASEHNYFTTNRFWLLLTEDPGDIDLL--EDPEI 191
                         ::||..|.:.|:.:|  |.|........:.||::.:...|:.:|:  |.|..
Human   278 -------------VILLYCSKDEAVLIL--SEARSLGLTGYDFFWIVPSLVSGNTELIPKEFPSG 327

  Fly   192 FIPP-----DSELRVLHYENVGNFSCSLIDLYKVAAWKPLKRTLVGHNIRNSRHVIHALQHFGSA 251
            .|..     |..|.....:.:|..:.:...:.:..::.|..:......:......:|.|..|...
Human   328 LISVSYDDWDYSLEARVRDGIGILTTAASSMLEKFSYIPEAKASCYGQMERPEVPMHTLHPFMVN 392

  Fly   252 ITY-RQDL----EGIVFNSAIVIAFPDLFTNIE--------DLSLRH------------------ 285
            :|: .:||    ||...:..:|:...:.....|        .|||||
Human   393 VTWDGKDLSFTEEGYQVHPRLVVIVLNKDREWEKVGKWENHTLSLRHAVWPRYKSFSDCEPDDNH 457

  Fly   286 ----------------IDTIS--------------KVNHR-----------------LMLELANR 303
                            ||.::              |:|:.                 ::.:|:..
Human   458 LSIVTLEEAPFVIVEDIDPLTETCVRNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSRT 522

  Fly   304 LNMSYNTYQTVN--YGWRQPNGSFDGLMGR--FQRYELDLAQLAIFMRLDRIALVDFVAETYRVR 364
            :..:|:.|...|  :| ::.|..::|::|.  :||..:.:..|.|  ..:|..:|||........
Human   523 VKFTYDLYLVTNGKHG-KKVNNVWNGMIGEVVYQRAVMAVGSLTI--NEERSEVVDFSVPFVETG 584

  Fly   365 AGIMFRQPPLSAVANIFAMPFENDVWVSI-LMLLIITTVVLVLELFFS-------------PHNH 415
            ..:|..:...:...:.|..||...|||.: :||||::.:.:.:..:||             ||..
Human   585 ISVMVSRSNGTVSPSAFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYNRNLAKGKAPHGP 649

  Fly   416 DMSYMDTLNFVWGAMCQQGFYVEVRN---RSARIIVFT-TFVAALFLFTSFSANIVALL--QSPS 474
            ..:....:..:||.:....  |.|:|   .:::|:|.. .|.|.:|| .|::||:.|.:  :...
Human   650 SFTIGKAIWLLWGLVFNNS--VPVQNPKGTTSKIMVSVWAFFAVIFL-ASYTANLAAFMIQEEFV 711

  Fly   475 DAIQSLSDLG-------QSPLEIGVQDTQYNKIYFTESTDPVTKNLY---HKKIASKGENIYMRP 529
            |.:..|||..       ..|...|...        ..||:...:|.|   |:.:....:......
Human   712 DQVTGLSDKKFQRPHDYSPPFRFGTVP--------NGSTERNIRNNYPYMHQYMTKFNQKGVEDA 768

  Fly   530 LLGMEKMRTGLFAYQVELQAGYQIVSDTFSEPEKCGLMELEP---FQLPMLAIPTRKNFPYKELI 591
            |:.::..:...|.|...: ..|:...|     |.|.|:.:..   |......|..:|..|
Human   769 LVSLKTGKLDAFIYDAAV-LNYKAGRD-----EGCKLVTIGSGYIFATTGYGIALQKGSP----- 822

  Fly   592 RRQLRWQREVSLV--------NREERKWIPQKPKCEGGVGGFVSIGITECRYALGIF---GCGAA 645
                 |:|::.|.        ..||.:.:.....|.......:|..:.....| |:|   ....|
Human   823 -----WKRQIDLALLQFVGDGEMEELETLWLTGICHNEKNEVMSSQLDIDNMA-GVFYMLAAAMA 881

  Fly   646 VSFVLFLFEFIF 657
            :|.:.|::|.:|
Human   882 LSLITFIWEHLF 893

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75d	NP_649074.2	Periplasmic_Binding_Protein_Type_2	299..>483	CDD:304360	49/207 (24%)
Ir75d	NP_649074.2	Lig_chan	388..644	CDD:278489	59/299 (20%)
GRIN2A	XP_016878661.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156033
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740