DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir75d and GRIK4

DIOPT Version :9

Sequence 1:	NP_649074.2	Gene:	Ir75d / 40065	FlyBaseID:	FBgn0036829	Length:	675	Species:	Drosophila melanogaster
Sequence 2:	NP_001269399.1	Gene:	GRIK4 / 2900	HGNCID:	4582	Length:	956	Species:	Homo sapiens

Alignment Length:	739	Identity:	158/739 - (21%)
Similarity:	280/739 - (37%)	Gaps:	213/739 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 VVCHTDIADFRLWKLWQHFNLNNFYVQVSTESSLRDLQHVDALDEHKDAPP-------PKS---- 118
            ::|........|.||.:.|.::            :|...|..||:.:|..|       .|:
Human   164 LICAKAECLLNLEKLLRQFLIS------------KDTLSVRMLDDTRDPTPLLKEIRDDKTATII 216

  Fly   119 FHANNS-THWETSFLLPALPYKMGILL---------LEFS-------SECALNLLRWSAASE-HN 165
            .|||.| :|   :.||.|.  ::|::.         ||||       .:..:|:|.:|..:: |.
Human   217 IHANASMSH---TILLKAA--ELGMVSAYYTYIFTNLEFSLQRMDSLVDDRVNILGFSIFNQSHA 276

  Fly   166 YF-----TTNRFW----------------LLLTEDPGDI-----DLLEDPEIFIPPDS------- 197
            :|     :.|:.|                .||.:....:     :|....||.:.|.|
Human   277 FFQEFAQSLNQSWQENCDHVPFTGPALSSALLFDAVYAVVTAVQELNRSQEIGVKPLSCGSAQIW 341

  Fly   198 --------ELRVLHYENV-GNFSCSLIDLYKVAAWKPLKRTLVGHNIRNSRHVIHAL---QHFGS 250
                    .||::..|.: |:...:........|.|.|:.|..|.......||...|   .|.
Human   342 QHGTSLMNYLRMVELEGLTGHIEFNSKGQRSNYALKILQFTRNGFRQIGQWHVAEGLSMDSHL-- 404

  Fly   251 AITYRQDLEGIVFNSAIVIAFPDLFTNIEDLSLRHIDTISKVNHR--------------LMLELA 301
               |..::...:||:.:|:.     |.:|:..|     :.|.||:              ::.|||
Human   405 ---YASNISDTLFNTTLVVT-----TILENPYL-----MLKGNHQEMEGNDRYEGFCVDMLKELA 456

  Fly   302 NRLNMSYNTYQTVN--YGWRQPNGSFDGLMGRFQRYELDLAQLAIFMRLDRIALVDF-------- 356
            ..|..:|......:  ||..:.||::.|::|.....:.|||...:.:..:|..::||
Human   457 EILRFNYKIRLVGDGVYGVPEANGTWTGMVGELIARKADLAVAGLTITAEREKVIDFSKPFMTLG 521

  Fly   357 VAETYRVRAGIMFRQPPLSAVANIFAMPFENDVWVSILMLLIITTVVLVLEL------FFSPHN- 414
            ::..|||..|   |:|...:    |..||...||:.:|:..:..:.||.|..      ::|||.
Human   522 ISILYRVHMG---RKPGYFS----FLDPFSPGVWLFMLLAYLAVSCVLFLVARLTPYEWYSPHPC 579

  Fly   415 ---------HDMSYMDTLNFVWGAMCQQGFYVEVRNRSARIIVFTTFVAALFLFTSFSANIVALL 470
                     :..|..::|.|..|...|||..:..|..|.|.:....:...|.:.:|::||:.|.|
Human   580 AQGRCNLLVNQYSLGNSLWFPVGGFMQQGSTIAPRALSTRCVSGVWWAFTLIIISSYTANLAAFL 644

  Fly   471 --QSPSDAIQSLSDLG-QSPLEIGVQDTQYNKIYFTESTDPVTKNLYHKKIASKGENIYMRPL-L 531
              |.....|:|:.||. |:.:|.|......:..:|..|.....:.::: .:.||..:::::.. .
Human   645 TVQRMDVPIESVDDLADQTAIEYGTIHGGSSMTFFQNSRYQTYQRMWN-YMYSKQPSVFVKSTEE 708

  Fly   532 GMEKMRTGLFAYQVELQAGYQIVSDTFSE---PEKC------GLMELEPFQLPM-LAIPTRKNFP 586
            |:.::....:|:.:|         .|.:|   ...|      ||::.:.:.:.| :....|..|
Human   709 GIARVLNSNYAFLLE---------STMNEYYRQRNCNLTQIGGLLDTKGYGIGMPVGSVFRDEF- 763

  Fly   587 YKELIRRQLRWQREVSLVNREERKWIPQKPKCEGGVG-----------GFVSIGITECRYALGIF 640
              :|...||:....:.::   :|||      .|||..           |..:||        |||
Human   764 --DLAILQLQENNRLEIL---KRKW------WEGGKCPKEEDHRAKGLGMENIG--------GIF 809

  Fly   641 G---CGAAVSFVLFLFEFIF--RH 659
            .   ||..|:..:.:.||::  ||
Human   810 VVLICGLIVAIFMAMLEFLWTLRH 833

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75d	NP_649074.2	Periplasmic_Binding_Protein_Type_2	299..>483	CDD:304360	54/211 (26%)
Ir75d	NP_649074.2	Lig_chan	388..644	CDD:278489	64/299 (21%)
GRIK4	NP_001269399.1	PBP1_iGluR_Kainate_KA1_2	26..400	CDD:107389	51/252 (20%)
		ANF_receptor	43..382	CDD:279440	46/234 (20%)
		PBP2_iGluR_kainate_KA1	415..785	CDD:270442	88/408 (22%)
		Lig_chan	547..816	CDD:278489	64/298 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	863..889
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	931..956
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155768
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840