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Protein Alignment Ir75d and GRIK2

DIOPT Version :9

Sequence 1:	NP_649074.2	Gene:	Ir75d / 40065	FlyBaseID:	FBgn0036829	Length:	675	Species:	Drosophila melanogaster
Sequence 2:	NP_068775.1	Gene:	GRIK2 / 2898	HGNCID:	4580	Length:	908	Species:	Homo sapiens

Alignment Length:	783	Identity:	161/783 - (20%)
Similarity:	287/783 - (36%)	Gaps:	219/783 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 PDPKTRWGNQLPDMLVAYY--RHHGVHSLMLVVCHTDIADFRLWKLWQHFNLNNFY--------- 89
            |..:|||.:|:.|...::|  .:....||...:  .|:..|..||     .:...|
Human   128 PHIQTRWKHQVSDNKDSFYVSLYPDFSSLSRAI--LDLVQFFKWK-----TVTVVYDDSTGLIRL 185

  Fly    90 ---VQVSTESSLR-DLQHVDALDEHKDAPP-------PKSFHANNSTHWETSFLLPALPYKMGIL 143
               ::..:..:|| .::.:.|  :.|||.|       .|.||                      :
Human   186 QELIKAPSRYNLRLKIRQLPA--DTKDAKPLLKEMKRGKEFH----------------------V 226

  Fly   144 LLEFSSECALNLLRWSAAS------EHNYFTT------------------NRFWLLLTE------ 178
            :.:.|.|.|..:|:.:.|.      .|..|||                  ..|.:|.||
Human   227 IFDCSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSS 291

  Fly   179 --DPGDIDLLEDPEIFIPPDSEL--------RVLHYE---------------NVGNFSCS----- 213
              :...::.|:.|.   .|||.|        ..|.|:               .|.:..|:
Human   292 IIEKWSMERLQAPP---KPDSGLLDGFMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQCNRHKPW 353

  Fly   214 -----LIDLYKVAAWKPLKRTLVGHNIRNSR-----HVI----HALQHFG-----SAITYRQDLE 259
                 .:.|.|.|.|:.|...:..:.....|     .||    ..|:..|     |.:...:..:
Human   354 RFGTRFMSLIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNMTESQK 418

  Fly   260 GIVFN--------SAIVIAF---PDLFTNIEDLSLRHIDTISKVNHRLMLELANRLNMSY--NTY 311
            |...|        |.||...   |.:.....|..|...|........|:.||:..|..:|  ...
Human   419 GKPANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLV 483

  Fly   312 QTVNYGWR-QPNGSFDGLMGRFQRYELDLAQLAIFMRLDRIALVDFVAETYRVRAGIMFRQPPLS 375
            :...||.: ..||.::|::.....::.|||...:.:...|..::||......:...|::|:|. .
Human   484 EDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPN-G 547

  Fly   376 AVANIFAM--PFENDVWVSILMLLI-ITTVVLVLELF-----FSPH--NHDMSYMDT----LNFV 426
            ....:|:.  |...|:|:.||:..: ::.|:.|:..|     ::||  |.|...::.    ||..
Human   548 TNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSDVVENNFTLLNSF 612

  Fly   427 W---GAMCQQGFYVEVRNRSARIIVFTTFVAALFLFTSFSANIVALL-----QSPSDAIQSLSDL 483
            |   ||:.|||..:..:..|.||:....:...|.:.:|::||:.|.|     :||.|:...|:.
Human   613 WFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAK- 676

  Fly   484 GQSPLEIGVQDTQYNKIYFTESTDPVTKNLYHKK---IASKGENIYMRP-LLGMEKMRTGLFAYQ 544
             |:.:|.|..:......:|.:|    ..:.|.|.   ::|:.:::.::. ..|::::.|..:|:.
Human   677 -QTKIEYGAVEDGATMTFFKKS----KISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDYAFL 736

  Fly   545 VELQAGYQIVSDT--FSEPEKC------GLMELEPFQLPMLAIPTRKNFPYKELIR-RQLRWQRE 600
            :|        |.|  |.....|      ||::.:.:     .:.|....||::.|. ..|:.|.|
Human   737 ME--------STTIEFVTQRNCNLTQIGGLIDSKGY-----GVGTPMGSPYRDKITIAILQLQEE 788

  Fly   601 VSLVNREERKW----IPQKPKCEGGVGGFVSIGITECRYALGIF---GCGAAVSFVLFLFEFIFR 658
            ..|...:|:.|    .|::...|....|..:||        |||   ..|..:|..:.:.||:::
Human   789 GKLHMMKEKWWRGNGCPEEESKEASALGVQNIG--------GIFIVLAAGLVLSVFVAVGEFLYK 845

  Fly   659 HFK 661
            ..|
Human   846 SKK 848

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.