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Protein Alignment Ir75d and GRIK1

DIOPT Version :9

Sequence 1:	NP_649074.2	Gene:	Ir75d / 40065	FlyBaseID:	FBgn0036829	Length:	675	Species:	Drosophila melanogaster
Sequence 2:	NP_001317923.1	Gene:	GRIK1 / 2897	HGNCID:	4579	Length:	949	Species:	Homo sapiens

Alignment Length:	680	Identity:	146/680 - (21%)
Similarity:	264/680 - (38%)	Gaps:	158/680 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 YRHHGVHSLMLVVCHTDIADFRLWKLWQHFNLNNFYVQVSTES-SLRDLQHVDALDEHKDAPP-P 116
            ||:.||          ::..|||      .|::|.:|....|. |:..||          ||| |
Human   270 YRYSGV----------NMTGFRL------LNIDNPHVSSIIEKWSMERLQ----------APPRP 308

  Fly   117 KSFHANNSTHWETSFLLPAL------------------------PYKMGILLLEFSSECALNLLR 157
            ::...:.....|.:.:..|:                        |:::|...:....|.     |
Human   309 ETGLLDGMMTTEAALMYDAVYMVAIASHRASQLTVSSLQCHRHKPWRLGPRFMNLIKEA-----R 368

  Fly   158 WSAASEHNYFT-TNRFWLLLTEDPGDIDLLEDPEIFIPPDSELRVLHYENVGNFSCSLIDLYKVA 221
            |...:.|..|. ||.    |.:| .|:|::...|    ..:|      :..|..|   ..||||
Human   369 WDGLTGHITFNKTNG----LRKD-FDLDIISLKE----EGTE------KAAGEVS---KHLYKV- 414

  Fly   222 AWKPLKRTLVGHNIRNSRHVIHALQHFGSAITYRQDLEGIVFNSAIVIAFPDLFTNIED--LSLR 284
             ||.:       .|.||.   ..|....|......::...:.|..:::.     |.:|:  :..|
Human   415 -WKKI-------GIWNSN---SGLNMTDSNKDKSSNITDSLANRTLIVT-----TILEEPYVMYR 463

  Fly   285 HIDTISKVNHR-------LMLELANRLNMSYNTYQTVN--YGWRQPNGSFDGLMGRFQRYELDLA 340
            ..|.....|.|       |:.||:|.|...|:.....:  ||.:...|.::|::.....:..|||
Human   464 KSDKPLYGNDRFEGYCLDLLKELSNILGFIYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLA 528

  Fly   341 QLAIFMRLDRIALVDFVAETYRVRAGIMFRQPPLSAVANIFAM--PFENDVWVSILMLLI-ITTV 402
            ...:.:...|..::||......:...|::|:|. .....:|:.  |...|:|:.:|:..: ::.|
Human   529 VAPLTITYVREKVIDFSKPFMTLGISILYRKPN-GTNPGVFSFLNPLSPDIWMYVLLACLGVSCV 592

  Fly   403 VLVLELF-----FSPH--NHDMSYMDT----LNFVW---GAMCQQGFYVEVRNRSARIIVFTTFV 453
            :.|:..|     ::||  |.|...::.    ||..|   ||:.|||..:..:..|.||:....:.
Human   593 LFVIARFTPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWF 657

  Fly   454 AALFLFTSFSANIVALL-----QSPSDAIQSLSDLGQSPLEIGVQDTQYNKIYFTESTDPVTKNL 513
            ..|.:.:|::||:.|.|     :||.|:...|:.  |:.:|.|.........:|.:|    ..:.
Human   658 FTLIIISSYTANLAAFLTVERMESPIDSADDLAK--QTKIEYGAVRDGSTMTFFKKS----KIST 716

  Fly   514 YHKK---IASKGENIYMRPL-LGMEKMRTGLFAYQVELQAGYQIVSDTFSEPEKCGLMELEPFQL 574
            |.|.   ::|:.:...:|.. .|::::.|..:|..:|..:...:.....:..:..||::.:.:
Human   717 YEKMWAFMSSRQQTALVRNSDEGIQRVLTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGY-- 779

  Fly   575 PMLAIPTRKNFPYKELIR-RQLRWQREVSLVNREERKW----IPQKPKCEGGVGGFVSIGITECR 634
               .:.|....||::.|. ..|:.|.|..|...:|:.|    .|::...|....|..:||
Human   780 ---GVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEDNKEASALGVENIG----- 836

  Fly   635 YALGIF---GCGAAVSFVLFLFEFIFRHFK 661
               |||   ..|..:|..:.:.|||::..|
Human   837 ---GIFIVLAAGLVLSVFVAIGEFIYKSRK 863

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.