Protein Alignment Ir75d and GRID1

DIOPT Version :10

• Sequence 1: NP_649074.2
• Gene: Ir75d / 40065
• FlyBaseID: FBgn0036829
• Length: 675
• Species: Drosophila melanogaster
• Sequence 2: NP_060021.1
• Gene: GRID1 / 2894
• HGNCID: 4575
• Length: 1009
• Species: Homo sapiens
• Alignment Length: 661
• Identity: 144/661 - (21%)
• Similarity: 257/661 - (38%)
• Gaps: 141/661 - (21%)

  Fly    39 KTRWGNQLPDML---VAYYRHHGVHSLMLVVCHTDIADFRLWKLWQHFNLNNFYVQVSTESS--- 97
            ||...|:..|.|   :......|.||.:.....|::|           :.::.:|.|:.|.|
Human   213 KTEELNRYRDTLRRAILLLSPQGAHSFINEAVETNLA-----------SKDSHWVFVNEEISDPE 266

  Fly    98 LRDLQH-------------VDALDEHKDAPPPKSFHANNSTHWETSFLL-PALPYKM-------- 140
            :.||.|             ..|.|..|         ...:.|..:|.|. |...|..
Human   267 ILDLVHSALGRMTVVRQIFPSAKDNQK---------CTRNNHRISSLLCDPQEGYLQMLQISNLY 322

  Fly   141 ---GILLLEFSSECALNLLRW-SAASEHNYFTTNRFW-----LLLTEDPGDI----DLLEDPEIF 192
               .:|:|..:....|...:| |.||.:....:.:.|     :|.|...|.|    .::|..|..
Human   323 LYDSVLMLANAFHRKLEDRKWHSMASLNCIRKSTKPWNGGRSMLDTIKKGHITGLTGVMEFREDS 387

  Fly   193 IPPDSELRVL---HYENVGNFSCSLIDLYKVAAWKPLKRTLVGHNIRNSRHVIHALQH--FGSAI 252
            ..|..:..:|   :.|..|.      |:.|:|.|...|    |.|        .:||.  .||.
Human   388 SNPYVQFEILGTTYSETFGK------DMRKLATWDSEK----GLN--------GSLQERPMGSR- 433

  Fly   253 TYRQDLEGIVFNSAIVIAFPDLFT--NIEDLSLRH----IDTISKVNHRLMLELANRLNMSYNTY 311
                 |:|:......|:..|.:..  ||.....|:    ||.:.        .||..|...|..|
Human   434 -----LQGLTLKVVTVLEEPFVMVAENILGQPKRYKGFSIDVLD--------ALAKALGFKYEIY 485

  Fly   312 QTVN--YGWRQPNGSFDGLMGRFQRYELDLAQLAIFMRLDRIALVDFVAETYRVRAGIMFRQPPL 374
            |..:  ||.:..|.|::|::|.......|||..||.:..:|.::|||.........||:.::|..
Human   486 QAPDGRYGHQLHNTSWNGMIGELISKRADLAISAITITPERESVVDFSKRYMDYSVGILIKKPEE 550

  Fly   375 S-AVANIFAMPFENDVWVSILMLL-IITTVVLVLELFFSPHNHDM-----SYMDTLN----FVWG 428
            . ::.::|| ||:..||..|...: ::..::.||....:......     |...||:    .|:|
Human   551 KISIFSLFA-PFDFAVWACIAAAIPVVGVLIFVLNRIQAVRAQSAAQPRPSASATLHSAIWIVYG 614

  Fly   429 AMCQQGFYVEVRNRSARIIVFTTFVAALFLFTSFSANIVALL-----QSPSDAIQSLSDLGQSPL 488
            |..|||....|.:.:.||::.:.::..|.:.:|::||:.|.|     .:|....|.||.  |..:
Human   615 AFVQQGGESSVNSMAMRIVMGSWWLFTLIVCSSYTANLAAFLTVSRMDNPIRTFQDLSK--QVEM 677

  Fly   489 EIG-VQDTQYNKIYFTESTDPVTKN-----LYHKKIASKG--ENIYMRPLLGMEKMRTGLFAYQV 545
            ..| |:|:...:.:..:.|:|:.::     |: :.|:..|  :|....|..|:.|.:.|.:|:..
Human   678 SYGTVRDSAVYEYFRAKGTNPLEQDSTFAELW-RTISKNGGADNCVSSPSEGIRKAKKGNYAFLW 741

  Fly   546 ELQ-AGYQIVSDTFSEPEKCGLMEL-EPFQLPMLAIPTRKNFPYKELIRRQLRWQREVSLVNREE 608
            ::. ..|..::|     :.|.:..: .........|..:...||::|..:::...::...::..:
Human   742 DVAVVEYAALTD-----DDCSVTVIGNSISSKGYGIALQHGSPYRDLFSQRILELQDTGDLDVLK 801

  Fly   609 RKWIPQKPKCE 619
            :||.|...:|:
Human   802 QKWWPHMGRCD 812

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir75d	NP_649074.2	Periplasmic_Binding_Protein_Type_2	299..>372	CDD:473866	23/74 (31%)
		Lig_chan	386..643	CDD:459656	53/259 (20%)
GRID1	NP_060021.1	Interaction with CBLN1. /evidence=ECO:0000250|UniProtKB:Q61627	21..436		55/266 (21%)
		PBP1_iGluR_delta_1	25..425	CDD:380615	50/249 (20%)
		PBP2_iGluR_delta_1	436..806	CDD:270448	87/386 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	930..954