DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ir75d and GRIA3

DIOPT Version :9

Sequence 1:NP_649074.2 Gene:Ir75d / 40065 FlyBaseID:FBgn0036829 Length:675 Species:Drosophila melanogaster
Sequence 2:NP_000819.4 Gene:GRIA3 / 2892 HGNCID:4573 Length:894 Species:Homo sapiens


Alignment Length:713 Identity:145/713 - (20%)
Similarity:260/713 - (36%) Gaps:188/713 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    44 NQLPDMLVAYYRH-HGVHSLMLVVCHTDIADFRLWKLWQH--FNLNNFYVQVSTESSL--RDLQH 103
            |.:.:.:|...:| .|.|.::..:..|||    |.:...|  .|:..|.: |:.|:.:  :.:|.
Human   227 NTILEQVVILGKHSRGYHYMLANLGFTDI----LLERVMHGGANITGFQI-VNNENPMVQQFIQR 286

  Fly   104 VDALDEH-----KDAPPPKSFHANNSTHWETSFLL---------------------------PAL 136
            ...|||.     |:||..   :.:..||  .:.|:                           ||:
Human   287 WVRLDEREFPEAKNAPLK---YTSALTH--DAILVIAEAFRYLRRQRVDVSRRGSAGDCLANPAV 346

  Fly   137 PYKMGILLLEFSSECALNLLRWSAASEHNYFTTNRFWLLLTEDPGDIDLLE-------------D 188
            |:..||     ..|.||.:::....:.:..|.|.......|     ||:.|             :
Human   347 PWSQGI-----DIERALKMVQVQGMTGNIQFDTYGRRTNYT-----IDVYEMKVSGSRKAGYWNE 401

  Fly   189 PEIFIPPDSELRVLHYENVGNFSCSLIDLYKVAAWKPLKRTLVGHNIRNSRHVIHALQHFGSAIT 253
            .|.|:|       ...:.:.|.|.|           ...||:|...|..|.:|::...|      
Human   402 YERFVP-------FSDQQISNDSAS-----------SENRTIVVTTILESPYVMYKKNH------ 442

  Fly   254 YRQDLEGIVFNSAIVIAFPDLFTNIEDLSLRHIDTISKVNHR-------LMLELANRLNMSY--N 309
              :.|||                                |.|       |..|:|..:.:.|  :
Human   443 --EQLEG--------------------------------NERYEGYCVDLAYEIAKHVRIKYKLS 473

  Fly   310 TYQTVNYGWRQPNGS-FDGLMGRFQRYELDLAQLAIFMRLDRIALVDFVAETYRVRAGIMFRQPP 373
            ......||.|.|... ::|::|.......|:|...:.:.|.|..::||......:...||.::|.
Human   474 IVGDGKYGARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQ 538

  Fly   374 LSAVANIFAM--PFENDVWVSILMLLIITTVVLVLELFFSPHN--------------------HD 416
            .|. ..:|:.  |...::|:.|:...|..:|||.|...|||:.                    ::
Human   539 KSK-PGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDPQSPPDPPNE 602

  Fly   417 MSYMDTLNFVWGAMCQQGFYVEVRNRSARIIVFTTFVAALFLFTSFSANIVALLQ-----SPSDA 476
            ....::|.|..||..|||..:..|:.|.||:....:...|.:.:|::||:.|.|.     ||   
Human   603 FGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSP--- 664

  Fly   477 IQSLSDLG-QSPLEIGVQDTQYNKIYFTESTDPVTKNLYHKKIASKGENIYMRPLL-GMEKMR-- 537
            |:|..||. |:.:..|..|:...|.:|..|...|.:.:: ..:.|...:::.:... |:.::|  
Human   665 IESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMW-SYMKSAEPSVFTKTTADGVARVRKS 728

  Fly   538 TGLFAYQVELQAGYQIVSDTFSEPEKCGLMEL-EPFQLPMLAIPTRKNFPYKELIRRQLRWQREV 601
            .|.||:.:|     ..:::...:.:.|..|:: .........:.|.|....:..:...:....|.
Human   729 KGKFAFLLE-----STMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALRNAVNLAVLKLNEQ 788

  Fly   602 SLVNREERKWIPQKPKCEGGVGGFVSIGITECRYALGIFGC------GAAVSFVLFLFEFIFR 658
            .|:::.:.||...|.:|  |.||..|...|.......:.|.      |..::.::.|.||.::
Human   789 GLLDKLKNKWWYDKGEC--GSGGGDSKDKTSALSLSNVAGVFYILVGGLGLAMMVALIEFCYK 849

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
Ir75dNP_649074.2 Periplasmic_Binding_Protein_Type_2 299..>483 CDD:304360 52/213 (24%)
Lig_chan 388..644 CDD:278489 63/291 (22%)
GRIA3NP_000819.4 PBP1_iGluR_AMPA_GluR3 35..409 CDD:380610 41/208 (20%)
PBP2_iGluR_AMPA 422..805 CDD:270433 90/432 (21%)
Glutamate binding. /evidence=ECO:0000250 508..510 0/1 (0%)