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Protein Alignment Ir75d and GRIA2

DIOPT Version :9

Sequence 1:	NP_649074.2	Gene:	Ir75d / 40065	FlyBaseID:	FBgn0036829	Length:	675	Species:	Drosophila melanogaster
Sequence 2:	NP_000817.5	Gene:	GRIA2 / 2891	HGNCID:	4572	Length:	883	Species:	Homo sapiens

Alignment Length:	783	Identity:	153/783 - (19%)
Similarity:	277/783 - (35%)	Gaps:	229/783 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 PDM------LVAYYR----------HHGVHSLMLVVCHTDIADFRLWKLWQHF-----NLNNFYV 90
            ||:      |:.||:          ..|:.:|..|:      |....|.||..     |:||...
Human   130 PDLKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAVL------DSAAEKKWQVTAINVGNINNDKK 188

  Fly    91 QVSTESSLRDLQ---------------------HVDALDEHKDAPPPKSFHANNSTHWETSFLLP 134
            .....|..:||:                     .|..:.:|     .|.:|          :::.
Human   189 DEMYRSLFQDLELKKERRVILDCERDKVNDIVDQVITIGKH-----VKGYH----------YIIA 238

  Fly   135 ALPYKMGILL-LEF--------------SSECALNLLRWSAASEHNY----FTTNRFWLLLTEDP 180
            .|.:..|.|| ::|              .|..:..:.|||...|..|    .||.::...||.|.
Human   239 NLGFTDGDLLKIQFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYPGAHTTTIKYTSALTYDA 303

  Fly   181 GDI----------------------DLLEDPEI----FIPPDSELRVLHYENVG----------- 208
            ..:                      |.|.:|.:    .:..:..|:.:..|.:.
Human   304 VQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKR 368

  Fly   209 -NFSCSLIDL-----YKVAAWKPLKRTLVGHNIRNSRHVIHALQHFGSAITYRQDLEGIVFNSAI 267
             |::.::::|     .|:..|..:.:.:|            .|....|.    .|..|:. |..:
Human   369 INYTINIMELKTNGPRKIGYWSEVDKMVV------------TLTELPSG----NDTSGLE-NKTV 416

  Fly   268 VIAFPDLFTNIEDLSLRHIDTISKVNHRLM--------------LELANRLNMSYNTYQTV---- 314
            |:      |.|    |.....:.|.||.::              .|:|......|..  |:
Human   417 VV------TTI----LESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKL--TIVGDG 469

  Fly   315 NYGWRQPNGS-FDGLMGRFQRYELDLAQLAIFMRLDRIALVDFVAETYRVRAGIMFRQPPLSAVA 378
            .||.|..:.. ::|::|.....:.|:|...:.:.|.|..::||......:...||.::|..|. .
Human   470 KYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSK-P 533

  Fly   379 NIFAM--PFENDVWVSILMLLIITTVVLVLELFFSPHN-HDMSYMD--------------TLNFV 426
            .:|:.  |...::|:.|:...|..:|||.|...|||:. |...:.|              ..|.:
Human   534 GVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSL 598

  Fly   427 W---GAMCQQGFYVEVRNRSARIIVFTTFVAALFLFTSFSANIVALLQ-----SPSDAIQSLSDL 483
            |   ||..|||..:..|:.|.||:....:...|.:.:|::||:.|.|.     ||.::.:.||.
Human   599 WFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSK- 662

  Fly   484 GQSPLEIGVQDTQYNKIYFTESTDPVTKNLYHKKIASKGENIYMRPLL-GMEKMR--TGLFAYQV 545
             |:.:..|..|:...|.:|..|...|...:: ..:.|...::::|... |:.::|  .|.:||.:
Human   663 -QTEIAYGTLDSGSTKEFFRRSKIAVFDKMW-TYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLL 725

  Fly   546 ELQAGYQIVSDTFSEPEKCGLMEL-EPFQLPMLAIPTRKNFPYKELIRRQLRWQREVSLVNREER 609
            |     ..:::...:.:.|..|:: .........|.|.|....:..:...:....|..::::.:.
Human   726 E-----STMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRTPVNLAVLKLSEQGVLDKLKN 785

  Fly   610 KWIPQKPKCEGGVGGFVSIGITECRYAL------GIF-----GCGAAVSFVLFLFEFIFRHFKQV 663
            ||...|.:|     |....|..|...||      |:|     |.|.|:  ::.|.||.::...:.
Human   786 KWWYDKGEC-----GAKDSGSKEKTSALSLSNVAGVFYILVGGLGLAM--LVALIEFCYKSRAEA 843

  Fly   664 YRI 666
            .|:
Human   844 KRM 846

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.