Protein Alignment Ir75d and Grin2b

DIOPT Version :10

• Sequence 1: NP_649074.2
• Gene: Ir75d / 40065
• FlyBaseID: FBgn0036829
• Length: 675
• Species: Drosophila melanogaster
• Sequence 2: NP_036706.1
• Gene: Grin2b / 24410
• RGDID: 2738
• Length: 1482
• Species: Rattus norvegicus
• Alignment Length: 618
• Identity: 130/618 - (21%)
• Similarity: 228/618 - (36%)
• Gaps: 138/618 - (22%)

  Fly   105 DALDEHKDAPPPKSFHANNSTHWETSFLLPALPYKMGILLLEFSSECALNLLRWSAASEHNYFTT 169
            |.|.||...|.|||...|  ||.:..:                    ..|:|
  Rat   306 DMLSEHSFIPEPKSSCYN--THEKRIY--------------------QSNML------------- 335

  Fly   170 NRFWLLLTEDPGDIDLLED-----PEIFIPPDSELRVLHYENVGNFSCSLIDLYKVAAWKPLKRT 229
            ||:.:.:|.:..::...||     |::.|...::.|  .:|.||.:....:.: |...|   .|.
  Rat   336 NRYLINVTFEGRNLSFSEDGYQMHPKLVIILLNKER--KWERVGKWKDKSLQM-KYYVW---PRM 394

  Fly   230 LVGHNIRNSRHV-IHALQHFGSAITYRQD-LEGIVFNSAIVIAFPDLFTNIEDLSLRHIDTISK- 291
            ......:...|: |..|:.....|....| |.|....:.:......:..|..|....:|....|
  Rat   395 CPETEEQEDDHLSIVTLEEAPFVIVESVDPLSGTCMRNTVPCQKRIISENKTDEEPGYIKKCCKG 459

  Fly   292 --VNHRLMLELANRLNMSYNTYQTVN--YGWRQPNGSFDGLMGRFQRYELDLAQLAIFMRLDRIA 352
              ::  ::.:::..:..:|:.|...|  :| ::.||:::|::|........:|..::.:..:|..
  Rat   460 FCID--ILKKISKSVKFTYDLYLVTNGKHG-KKINGTWNGMIGEVVMKRAYMAVGSLTINEERSE 521

  Fly   353 LVDFVAETYRVRAGIMFRQPPLSAVANIFAMPFENDVWVSI-LMLLIITTVVLVLELFFSPHNHD 416
            :|||..........:|..:...:...:.|..||..||||.: :||||::.|.:.:..:|||..::
  Rat   522 VVDFSVPFIETGISVMVSRSNGTVSPSAFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGYN 586

  Fly   417 MSYMD-------------TLNFVWGAMCQQGFYVEVRN---RSARIIVFT-TFVAALFLFTSFSA 464
            ....|             .:..:||.:....  |.|:|   .:::|:|.. .|.|.:|| .|::|
  Rat   587 RCLADGREPGGPSFTIGKAIWLLWGLVFNNS--VPVQNPKGTTSKIMVSVWAFFAVIFL-ASYTA 648

  Fly   465 NIVALL--QSPSDAIQSLSDLG-------QSPLEIGVQDTQYNKIYFTESTDPVTKNLYHKKIAS 520
            |:.|.:  :...|.:..|||..       ..|...|...        ..||:...:|.|.:..|.
  Rat   649 NLAAFMIQEEYVDQVSGLSDKKFQRPNDFSPPFRFGTVP--------NGSTERNIRNNYAEMHAY 705

  Fly   521 KGENIYMR----PLLGMEKMRTGLFAYQVELQAGYQIVSDTFSEPEKCGLMELEPFQLPMLAIPT 581
            .|: ...|    .||.::..:...|.|...: ..|....|     |.|.|          :.|.:
  Rat   706 MGK-FNQRGVDDALLSLKTGKLDAFIYDAAV-LNYMAGRD-----EGCKL----------VTIGS 753

  Fly   582 RKNFP---YKELIRRQLRWQREVSL----------VNREERKWIPQKPKCEGGVGGFVSIGITEC 633
            .|.|.   |...|::...|:|:|.|          :...|..|:  ...|.......:|..:...
  Rat   754 GKVFASTGYGIAIQKDSGWKRQVDLAILQLFGDGEMEELEALWL--TGICHNEKNEVMSSQLDID 816

  Fly   634 RYALGIF---GCGAAVSFVLF----LFEFIFRH 659
            ..| |:|   |...|:|.:.|    ||.:.|||
  Rat   817 NMA-GVFYMLGAAMALSLITFICEHLFYWQFRH 848

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir75d	NP_649074.2	Periplasmic_Binding_Protein_Type_2	299..>372	CDD:473866	14/74 (19%)
		Lig_chan	386..643	CDD:459656	67/303 (22%)
Grin2b	NP_036706.1	PBP1_iGluR_NMDA_NR2	33..388	CDD:380601	24/119 (20%)
		PBP2_iGluR_NMDA_Nr2	403..803	CDD:270436	90/432 (21%)
		Pore-forming. /evidence=ECO:0000269|PubMed:24876489, ECO:0000305|PubMed:24876489	604..623		4/20 (20%)
		NMDAR2_C	840..1482	CDD:463148	5/9 (56%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1161..1194
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1269..1301
		Interaction with DAPK1. /evidence=ECO:0000250|UniProtKB:Q01097	1292..1304
		PDZ-binding	1480..1482