DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ir75d and Grin2b

DIOPT Version :9

Sequence 1:NP_649074.2 Gene:Ir75d / 40065 FlyBaseID:FBgn0036829 Length:675 Species:Drosophila melanogaster
Sequence 2:NP_036706.1 Gene:Grin2b / 24410 RGDID:2738 Length:1482 Species:Rattus norvegicus


Alignment Length:618 Identity:130/618 - (21%)
Similarity:228/618 - (36%) Gaps:138/618 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   105 DALDEHKDAPPPKSFHANNSTHWETSFLLPALPYKMGILLLEFSSECALNLLRWSAASEHNYFTT 169
            |.|.||...|.|||...|  ||.:..:                    ..|:|             
  Rat   306 DMLSEHSFIPEPKSSCYN--THEKRIY--------------------QSNML------------- 335

  Fly   170 NRFWLLLTEDPGDIDLLED-----PEIFIPPDSELRVLHYENVGNFSCSLIDLYKVAAWKPLKRT 229
            ||:.:.:|.:..::...||     |::.|...::.|  .:|.||.:....:.: |...|   .|.
  Rat   336 NRYLINVTFEGRNLSFSEDGYQMHPKLVIILLNKER--KWERVGKWKDKSLQM-KYYVW---PRM 394

  Fly   230 LVGHNIRNSRHV-IHALQHFGSAITYRQD-LEGIVFNSAIVIAFPDLFTNIEDLSLRHIDTISK- 291
            ......:...|: |..|:.....|....| |.|....:.:......:..|..|....:|....| 
  Rat   395 CPETEEQEDDHLSIVTLEEAPFVIVESVDPLSGTCMRNTVPCQKRIISENKTDEEPGYIKKCCKG 459

  Fly   292 --VNHRLMLELANRLNMSYNTYQTVN--YGWRQPNGSFDGLMGRFQRYELDLAQLAIFMRLDRIA 352
              ::  ::.:::..:..:|:.|...|  :| ::.||:::|::|........:|..::.:..:|..
  Rat   460 FCID--ILKKISKSVKFTYDLYLVTNGKHG-KKINGTWNGMIGEVVMKRAYMAVGSLTINEERSE 521

  Fly   353 LVDFVAETYRVRAGIMFRQPPLSAVANIFAMPFENDVWVSI-LMLLIITTVVLVLELFFSPHNHD 416
            :|||..........:|..:...:...:.|..||..||||.: :||||::.|.:.:..:|||..::
  Rat   522 VVDFSVPFIETGISVMVSRSNGTVSPSAFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGYN 586

  Fly   417 MSYMD-------------TLNFVWGAMCQQGFYVEVRN---RSARIIVFT-TFVAALFLFTSFSA 464
            ....|             .:..:||.:....  |.|:|   .:::|:|.. .|.|.:|| .|::|
  Rat   587 RCLADGREPGGPSFTIGKAIWLLWGLVFNNS--VPVQNPKGTTSKIMVSVWAFFAVIFL-ASYTA 648

  Fly   465 NIVALL--QSPSDAIQSLSDLG-------QSPLEIGVQDTQYNKIYFTESTDPVTKNLYHKKIAS 520
            |:.|.:  :...|.:..|||..       ..|...|...        ..||:...:|.|.:..|.
  Rat   649 NLAAFMIQEEYVDQVSGLSDKKFQRPNDFSPPFRFGTVP--------NGSTERNIRNNYAEMHAY 705

  Fly   521 KGENIYMR----PLLGMEKMRTGLFAYQVELQAGYQIVSDTFSEPEKCGLMELEPFQLPMLAIPT 581
            .|: ...|    .||.::..:...|.|...: ..|....|     |.|.|          :.|.:
  Rat   706 MGK-FNQRGVDDALLSLKTGKLDAFIYDAAV-LNYMAGRD-----EGCKL----------VTIGS 753

  Fly   582 RKNFP---YKELIRRQLRWQREVSL----------VNREERKWIPQKPKCEGGVGGFVSIGITEC 633
            .|.|.   |...|::...|:|:|.|          :...|..|:  ...|.......:|..:...
  Rat   754 GKVFASTGYGIAIQKDSGWKRQVDLAILQLFGDGEMEELEALWL--TGICHNEKNEVMSSQLDID 816

  Fly   634 RYALGIF---GCGAAVSFVLF----LFEFIFRH 659
            ..| |:|   |...|:|.:.|    ||.:.|||
  Rat   817 NMA-GVFYMLGAAMALSLITFICEHLFYWQFRH 848

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
Ir75dNP_649074.2 Periplasmic_Binding_Protein_Type_2 299..>483 CDD:304360 48/205 (23%)
Lig_chan 388..644 CDD:278489 67/302 (22%)
Grin2bNP_036706.1 PBP1_iGluR_NMDA_NR2 33..393 CDD:107373 26/127 (20%)
PBP2_iGluR_NMDA_Nr2 403..803 CDD:270436 90/432 (21%)
HisJ <459..>542 CDD:223904 14/85 (16%)
Lig_chan 557..829 CDD:278489 67/302 (22%)
Pore-forming. /evidence=ECO:0000269|PubMed:24876489, ECO:0000305|PubMed:24876489 604..623 4/20 (20%)