DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir75d and Grik4

DIOPT Version :9

Sequence 1:	NP_649074.2	Gene:	Ir75d / 40065	FlyBaseID:	FBgn0036829	Length:	675	Species:	Drosophila melanogaster
Sequence 2:	NP_036704.1	Gene:	Grik4 / 24406	RGDID:	2734	Length:	956	Species:	Rattus norvegicus

Alignment Length:	743	Identity:	155/743 - (20%)
Similarity:	283/743 - (38%)	Gaps:	221/743 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 VVCHTDIADFRLWKLWQHFNLNNFYVQVSTESSLRDLQHVDALDEHKDAPP-------PKS---- 118
            ::|........|.||.:.|.::            :|...|..||:.:|..|       .|:
  Rat   164 LICAKAECLLNLEKLLRQFLIS------------KDTLSVRMLDDTRDPTPLLKEIRDDKTATII 216

  Fly   119 FHANNS-THWETSFLLPALPYKMGILL---------LEFS-------SECALNLLRWSAASE-HN 165
            .|||.| :|   :.||.|.  ::|::.         ||||       .:..:|:|.:|..:: |.
  Rat   217 IHANASMSH---TILLKAA--ELGMVSAYYTYIFTNLEFSLQRMDSLVDDRVNILGFSIFNQSHA 276

  Fly   166 YF-----TTNRFWLLLTED----PGDIDLLEDPEIF------IPPDSELRVLHYENVGNFSC--- 212
            :|     :.|:.|   .|:    |.....|....:|      :....||.......|...||
  Rat   277 FFQEFSQSLNQSW---QENCDHVPFTGPALSSALLFDAVYAVVTAVQELNRSQEIGVKPLSCGSA 338

  Fly   213 -------SLIDLYKVAAWKPLKRTLVGHNIRNSR-----HVIHALQ------------HFGSAIT 253
                   ||::..::...:    .|.||...||:     :.:..||            |....::
  Rat   339 QIWQHGTSLMNYLRMVELE----GLTGHIEFNSKGQRSNYALKILQFTRNGFRQIGQWHVAEGLS 399

  Fly   254 -----YRQDLEGIVFNSAIVIAFPDLFTNIEDLSLRHIDTISKVNHR--------------LMLE 299
                 |..::...:||:.:|:.     |.:|:..|     :.|.||:              ::.|
  Rat   400 MDSRLYASNISDSLFNTTLVVT-----TILENPYL-----MLKGNHQDMEGNDRYEGFCVDMLKE 454

  Fly   300 LANRLNMSYNTYQTVN--YGWRQPNGSFDGLMGRFQRYELDLAQLAIFMRLDRIALVDF------ 356
            ||..|..:|......:  ||..:.||::.|::|.....:.|||...:.:..:|..::||
  Rat   455 LAEILRFNYKIRLVGDGVYGVPEANGTWTGMVGELIARKADLAVAGLTITAEREKVIDFSKPFMT 519

  Fly   357 --VAETYRVRAGIMFRQPPLSAVANIFAMPFENDVWVSILMLLIITTVVLVLEL------FFSPH 413
              ::..|||..|   |:|...:    |..||...||:.:|:..:..:.||.|..      ::|||
  Rat   520 LGISILYRVHMG---RRPGYFS----FLDPFSPGVWLFMLLAYLAVSCVLFLVARLTPYEWYSPH 577

  Fly   414 N----------HDMSYMDTLNFVWGAMCQQGFYVEVRNRSARIIVFTTFVAALFLFTSFSANIVA 468
            .          :..|..::|.|..|...|||..:..|..|.|.:....:...|.:.:|::||:.|
  Rat   578 PCAQGRCNLLVNQYSLGNSLWFPVGGFMQQGSTIAPRALSTRCVSGVWWAFTLIIISSYTANLAA 642

  Fly   469 LL-----QSPSDAIQSLSDLGQSPLEIGVQDTQYNKIYFTESTDPVTKNLYHKKIASKGENIYMR 528
            .|     :.|.:::..|:|  |:.:|.|......:..:|..|.....:.::: .:.||..:::::
  Rat   643 FLTVQRMEVPIESVDDLAD--QTAIEYGTIHGGSSMTFFQNSRYQTYQRMWN-YMYSKQPSVFVK 704

  Fly   529 PL-LGMEKMRTGLFAYQVELQAGYQIVSDTFSE---PEKC------GLMELEPFQLPM-LAIPTR 582
            .. .|:.::....:|:.:|         .|.:|   ...|      ||::.:.:.:.| :....|
  Rat   705 STEEGIARVLNSNYAFLLE---------STMNEYYRQRNCNLTQIGGLLDTKGYGIGMPVGSVFR 760

  Fly   583 KNFPYKELIRRQLRWQREVSLVNREERKWIPQKPKCEGGVG-----------GFVSIGITECRYA 636
            ..|   :|...||:....:.::   :|||      .|||..           |..:||
  Rat   761 DEF---DLAILQLQENNRLEIL---KRKW------WEGGKCPKEEDHRAKGLGMENIG------- 806

  Fly   637 LGIFG---CGAAVSFVLFLFEFIF--RH 659
             |||.   ||..|:..:.:.||::  ||
  Rat   807 -GIFVVLICGLIVAIFMAMLEFLWTLRH 833

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75d	NP_649074.2	Periplasmic_Binding_Protein_Type_2	299..>483	CDD:304360	53/214 (25%)
Ir75d	NP_649074.2	Lig_chan	388..644	CDD:278489	62/301 (21%)
Grik4	NP_036704.1	Periplasmic_Binding_Protein_type1	24..402	CDD:415822	51/261 (20%)
		PBP2_iGluR_kainate_KA1	415..785	CDD:270442	86/410 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	931..956
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349674
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840