Protein Alignment Ir75d and glr-3

DIOPT Version :10

• Sequence 1: NP_649074.2
• Gene: Ir75d / 40065
• FlyBaseID: FBgn0036829
• Length: 675
• Species: Drosophila melanogaster
• Sequence 2: NP_492017.3
• Gene: glr-3 / 172449
• WormBaseID: WBGene00001614
• Length: 836
• Species: Caenorhabditis elegans
• Alignment Length: 666
• Identity: 143/666 - (21%)
• Similarity: 251/666 - (37%)
• Gaps: 160/666 - (24%)

  Fly    56 HHGVHSLMLVVCHTD----IADFRLWKLWQHFNLNNFYVQVSTESSLRDLQHVDALDEHKDAPPP 116
            |:.|..:.||....|    |.|..:.....| ::|:.|:    |...:::.|..::...|...|
 Worm   234 HYVVMDMDLVTVDIDSIRGIEDCNITSFGVH-DVNSEYI----EDIRQEIVHKSSIRLPKKGVP- 292

  Fly   117 KSFHANNSTHWETSFLLPALPYKMGILLLEFSS-------ECALNLLRWSAASEHNYFTTNRFWL 174
                      :.||..:..|    .:|:....|       .|..:   |.:.|:    ...||:
 Worm   293 ----------YTTSIWIDTL----RLLIRSMKSIQIWDEPRCGSS---WKSGSD----IKKRFF- 335

  Fly   175 LLTEDPGDIDLLEDPEIFIPPDSELRVLHYENVGNFSCSLIDLY-------KVAAWKPLKRTLVG 232
                        |:|...|..|     ||:...|..|...:.:|       |.|.|....|
 Worm   336 ------------ENPLAGISGD-----LHWAPSGERSNYTLHVYRRTLSFQKFAEWSSRTR---- 379

  Fly   233 HNIRNSRHVIHALQHFGSAITYRQDLEGIVFNSAIVIAFP-DLFTNIEDLSLRHIDTISKVNHRL 296
             .|.:|..|:  :.:....:|    |||.....::.:..| .:.|:........||.:.|:
 Worm   380 -RIASSEAVV--IANSSEKLT----LEGKHLKISVYLEAPFVMITSNGSYEGYCIDLLHKI---- 433

  Fly   297 MLELANRLNMSYNTYQTVN---YGWRQPNGSFDGLMGRFQRYELDLAQLAIFMRLDRIALVDFVA 358
                ||.|..:| |.|.|.   ||.::.||.:.|::|..||.:.|||..::.:...|..::||..
 Worm   434 ----ANILKFTY-TIQKVRDNAYGSKESNGKWSGMVGELQRGDADLAVASLTISYGRSEVIDFTV 493

  Fly   359 ETYRVRAGIMFRQPPL-SAVANIFAMPFENDVWVSILMLLIITTVVLVLELFFSPH--------N 414
            ....:...|:|::|.: .:....|..|....||:.......:.:|.:.:....||:        |
 Worm   494 PYMHLGISILFKKPRIRDSDWFKFMDPLSTQVWIMTFASYFVVSVAIWIIAKISPYEQFERDEDN 558

  Fly   415 HDMSYMDT----LNFVWGAMC---QQGFYVEVRNRSARIIVFTTFVAALFLFTSFSANIVALL-- 470
            .....:|.    .|..|..:|   |||..:..|..|.|::....:..||.|.:|::||:.|:|
 Worm   559 GQYKPVDNQFSLRNSFWFTVCSLMQQGSELCPRAASTRLLTGIWWFFALILISSYTANLAAVLTT 623

  Fly   471 ---QSPSDAIQSLSDL-GQSPLEIGVQDTQYNKIYFTESTDPVTKNLYHKKIASKGENIYMRPLL 531
               ::|   |::..|| .|:.::.|.........:|.||.....:.::  ::.|....::::...
 Worm   624 RRMETP---IENADDLAAQTKIKYGTLGRGSTMSFFNESKIETYERMW--QLMSSSPGLFVQSSK 683

  Fly   532 -GMEKMRTGLFAYQVE-LQAGYQIVSDTFSEPEKCGLMEL--------EPFQLPMLAIPTRKNFP 586
             |:.::::..:||.:| ....|.:..|       |.||::        ....||       |..|
 Worm   684 EGIARVKSSDYAYLMESSMLEYAVERD-------CELMQIGGLIDQKGYGIGLP-------KGSP 734

  Fly   587 YKELIRRQ-LRWQREVSLVNREERKWIPQKPKCE----------GGVGGFVSIGITECRYALGIF 640
            |:|||... ||.|.:..|...:|:.|..:...||          ..:||...|.:.
 Worm   735 YRELISTAILRLQEKTELTELKEKWWKDKSVVCEQPKRKDQDDGESIGGIFIILVV--------- 790

  Fly   641 GCGAAVSFVLFLFEFI 656
              |..::.||.:||.|
 Worm   791 --GLVLTAVLVIFELI 804

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir75d	NP_649074.2	Periplasmic_Binding_Protein_Type_2	299..>372	CDD:473866	23/75 (31%)
		Lig_chan	386..643	CDD:459656	62/298 (21%)
glr-3	NP_492017.3	PBP1_iGluR_non_NMDA-like	21..385	CDD:380591	38/200 (19%)
		Periplasmic_Binding_Protein_Type_2	401..761	CDD:473866	87/387 (22%)