DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir75d and Grin3b

DIOPT Version :9

Sequence 1:	NP_649074.2	Gene:	Ir75d / 40065	FlyBaseID:	FBgn0036829	Length:	675	Species:	Drosophila melanogaster
Sequence 2:	NP_579842.2	Gene:	Grin3b / 170796	RGDID:	621705	Length:	1002	Species:	Rattus norvegicus

Alignment Length:	417	Identity:	79/417 - (18%)
Similarity:	143/417 - (34%)	Gaps:	85/417 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   296 LMLELANRLNMSYNTYQTVN--YGWRQPNGSFDGLMGRFQRYELDLAQLAIFMRLDRIALVDFVA 358
            |:..||..|...:..|...:  ||..: :|.:.||:|........:|..:..:...|..:|||.:
  Rat   483 LLERLAEDLAFDFELYIVGDGKYGALR-DGRWTGLVGDLLAGRAHMAVTSFSINSARSQVVDFTS 546

  Fly   359 ETYRVRAGIMFRQPPLSAVANIFAMPFENDVWVSILMLLIITTVVLVLELFFSPHNHD------- 416
            ..:....|||.|....::....|..|....:||.:...|.:|.:.|.|..:.||:...
  Rat   547 PFFSTSLGIMVRTRDTASPIGAFMWPLHWSMWVGVFAALHLTALFLTLYEWRSPYGLTPRGRNRG 611

  Fly   417 --MSYMDTLNFVWGAM-----------CQQGFYVEVRNRSARIIVFTTFVAALFLFTSFSANIVA 468
              .||...||..:..:           |..|          |.::....:..|.:.:|::||:.|
  Rat   612 TVFSYSSALNLCYAILFGRTVSSKTPKCPTG----------RFLMNLWAIFCLLVLSSYTANLAA 666

  Fly   469 LLQSPSDAIQSLSDLGQSPLEIGVQDTQYNKI-------YFTESTDPVTKNLYHKKIASKGENIY 526
            ::.. ....:.||.:....|....|..::..:       |...|...:..::......:....:.
  Rat   667 VMVG-DKTFEELSGIHDPKLHHPSQGFRFGTVWESSAEAYIKASFPEMHAHMRRHSAPTTPHGVA 730

  Fly   527 M----RPLLGMEKMRTGLFAYQVELQAGYQIVSDTFSEPEKCGLMEL-EPFQLPMLAIPTRKNFP 586
            |    .|.|....|...|..|:|.:.|             .|.|:.: :||.:....|...:|.|
  Rat   731 MLTSDPPKLNAFIMDKSLLDYEVSIDA-------------DCKLLTVGKPFAIEGYGIGLPQNSP 782

  Fly   587 YKELIRRQLRWQREVSLVNREERKWIPQKPKC-----------EGGVGGFVSIGITECRYALGIF 640
            ....:...:...:....::....||....| |           :.||..|..:.:..|      .
  Rat   783 LTSNLSEFISRYKSSGFIDLLHDKWYKMVP-CGKRVFAVTETLQMGVYHFSGLFVLLC------L 840

  Fly   641 GCGAAVSFVLFLFEFIFRHFKQVYRII 667
            |.|:|:  :..|.|.:|      ||::
  Rat   841 GLGSAL--LTSLGEHVF------YRLV 859

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75d	NP_649074.2	Periplasmic_Binding_Protein_Type_2	299..>483	CDD:304360	43/205 (21%)
Ir75d	NP_649074.2	Lig_chan	388..644	CDD:278489	50/298 (17%)
Grin3b	NP_579842.2	PBP1_iGluR_NMDA_NR3	21..405	CDD:107372
		PBP2_iGluR_NMDA_Nr3	414..808	CDD:270438	64/349 (18%)
		Lig_chan	576..842	CDD:278489	49/296 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	882..910
		Involved in the trafficking and surface expression of NMDARs. /evidence=ECO:0000250	951..984
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350053
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930