DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir75d and gria3a

DIOPT Version :9

Sequence 1:	NP_649074.2	Gene:	Ir75d / 40065	FlyBaseID:	FBgn0036829	Length:	675	Species:	Drosophila melanogaster
Sequence 2:	XP_005165152.1	Gene:	gria3a / 170452	ZFINID:	ZDB-GENE-020125-5	Length:	903	Species:	Danio rerio

Alignment Length:	661	Identity:	126/661 - (19%)
Similarity:	243/661 - (36%)	Gaps:	174/661 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 LPDMLVAYYRHHGVHSLMLVVCHTDIADFRLWKLWQ-HFNLNNFYVQVSTESSL--RDLQHVDAL 107
            |..:::|.....|.|.::..:..|:::   |.|::. ..|:..|.: ::.:|.:  :.||..:.|
Zfish   223 LEQVVIAGKNSRGYHYILANLGFTNMS---LDKVFSGGANITGFQI-INPDSPIVQQFLQRWERL 283

  Fly   108 DEHKDAPPPKSF---HANNSTHWETSFLLPALPY----KMGILLLEFSSECALN-LLRWSAASEH 164
            || ::.|..:|.   :.:..||.....:..|..|    ::.|.....:.:|..| .:.||..
Zfish   284 DE-REFPESRSSPLKYTSALTHDAILVIAEAFRYLRRQRVDISRRGSAGDCLANPAVPWSQG--- 344

  Fly   165 NYFTTNRFWLLLTEDPGDIDLLEDPEIFIPPDSELRV---------LHYENVGNFSCSLIDLY-- 218
                              ||:          :..|::         :.:::.|..|...:|:|
Zfish   345 ------------------IDI----------ERALKMVQVQGMTGNIQFDSFGRRSNYTVDVYEM 381

  Fly   219 ------KVAAWKPLK-------------------RTLVGHNIRNSRHVIHALQHFGSAITYRQDL 258
                  |:..|...:                   ||:|...|..:.:|::...:        ..|
Zfish   382 KPGGARKIGYWNEFEKFVYIVEQQVTNESSSVENRTIVVTTIMEAPYVMYKRNY--------MQL 438

  Fly   259 EGIVFNSAIVIAFPDLFTNIEDLSLRHIDTISKVNHR-------LMLELANRLNMSYNTYQTVN- 315
            ||                                |.|       |..|:|..:.:.|......:
Zfish   439 EG--------------------------------NDRYEGYCVDLASEIAKHVGIKYKLSIVADG 471

  Fly   316 -YGWRQP-NGSFDGLMGRFQRYELDLAQLAIFMRLDRIALVDFVAETYRVRAGIMFRQPPLSAVA 378
             ||.|.| ..:::|::|.......|:|...:.:.|.|..::||......:...||.::|..|. .
Zfish   472 KYGARDPETKTWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSK-P 535

  Fly   379 NIFAM--PFENDVWVSILMLLIITTVVLVLELFFSPHN-------------------HDMSYMDT 422
            .:|:.  |...::|:.|:...|..:|||.|...|||:.                   :|....::
Zfish   536 GVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLDDNEETKDPQTPPDPPNDFGIFNS 600

  Fly   423 LNFVWGAMCQQGFYVEVRNRSARIIVFTTFVAALFLFTSFSANIVALLQ-----SPSDAIQSLSD 482
            |.|..||..|||..:..|:.|.||:....:...|.:.:|::||:.|.|.     ||   |:|..|
Zfish   601 LWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSP---IESAED 662

  Fly   483 LG-QSPLEIGVQDTQYNKIYFTESTDPVTKNLY-HKKIASKGENIYMRPLLGMEKMR--TGLFAY 543
            |. |:.:..|..|:...|.:|..|...|.:.:: :.|.|.....:...| .|:.::|  .|.||:
Zfish   663 LAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFVKTTP-DGVARVRKSKGKFAF 726

  Fly   544 QVELQAGYQIVSDTFSEPEKCGLMEL-EPFQLPMLAIPTRKNFPYKELIRRQLRWQREVSLVNRE 607
            .:|     ..:::...:.:.|..|:: .........:.|.|....:..:...:....|..::::.
Zfish   727 LLE-----STMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALRTPVNLAVLKLSEQGILDKL 786

  Fly   608 ERKWIPQKPKC 618
            :.||...|.:|
Zfish   787 KNKWWYDKGEC 797

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75d	NP_649074.2	Periplasmic_Binding_Protein_Type_2	299..>483	CDD:304360	53/212 (25%)
Ir75d	NP_649074.2	Lig_chan	388..644	CDD:278489	59/260 (23%)
gria3a	XP_005165152.1	PBP1_iGluR_AMPA_GluR3	28..399	CDD:107382	35/211 (17%)
		ANF_receptor	39..382	CDD:279440	33/194 (17%)
		PBP2_iGluR_AMPA	415..797	CDD:270433	90/431 (21%)
		Lig_chan	547..810	CDD:278489	59/260 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591582
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.840