Protein Alignment Ir75d and gria2b

DIOPT Version :10

• Sequence 1: NP_649074.2
• Gene: Ir75d / 40065
• FlyBaseID: FBgn0036829
• Length: 675
• Species: Drosophila melanogaster
• Sequence 2: XP_068069253.1
• Gene: gria2b / 170451
• ZFINID: ZDB-GENE-020125-4
• Length: 944
• Species: Danio rerio
• Alignment Length: 728
• Identity: 153/728 - (21%)
• Similarity: 264/728 - (36%)
• Gaps: 198/728 - (27%)

  Fly    43 GNQ------LPDM------LVAYYR----------HHGVHSLMLVVCHTDIADFRLWKLWQHFNL 85
            |||      .||:      |:.||:          ..|:.:|.:|:   |.|..:.|:: ...|:
Zfish   119 GNQQFIIQMRPDIKGPLLSLIEYYKWDKFAYLYDSDRGLTTLQVVL---DTAAEKKWQV-TAINV 179

  Fly    86 NNFYVQVSTE---SSLRDLQH-------VDA-LDEHKDAPPP--------KSFH---ANNSTHWE 128
            .|...:...|   |..:||::       :|. .|:.||....        |.:|   ||
Zfish   180 GNMKDERKDEAYRSLFQDLENKKERRVILDCEQDKVKDIMEQVITIGRHVKGYHYIIAN------ 238

  Fly   129 TSFL---LPALPY----KMGILLLEFSSECALNL-LRWSAASEHNYFTTN---RFWLLLTEDPGD 182
            ..|:   |..:.|    ..|..:::|........ .||.|..|..|...:   |:...||.|.
Zfish   239 LGFVDGDLSKIQYGGANVSGFQIVDFDDPLVSKFDQRWEALEEKEYPGADSKIRYTSALTYDA-- 301

  Fly   183 IDLLEDPEIFIPPDSELRVLHYENV------GNFSCSLIDLYKVAAWKPLKRTL-------VGHN 234
            :.::.:         ..|.||.:.:      .|..|........|....::|.|       :..|
Zfish   302 VQVMTE---------AFRYLHKQRIDISRRANNGDCLANPAVPWAQGVEIERALKQVRVDGLTGN 357

  Fly   235 IRNSRHVIHALQHFGSAITYRQDLEGIVFNSAIVIAF-----------PDLFTNIEDLSLRH--- 285
            |:        ...:|..:.|..::..:..|.|:.|.:           .|||.| :.:.|.:
Zfish   358 IQ--------FDQYGKRVNYTVNVMELKSNGAVKIGYWNEVDKMVVTKSDLFPN-DTMGLENKTV 413

  Fly   286 -IDTISKV--------------NHR-------LMLELANRLNMSYNTYQTV---NYGWRQPNGS- 324
             :.||.:.              |.|       |..|:|......|. .:.|   .||.|.....
Zfish   414 IVTTILEAPYVMLKKNADLFMDNERYEGYCVDLAAEIAKHCGFKYQ-LKIVGDGKYGARDAETKI 477

  Fly   325 FDGLMGRFQRYELDLAQLAIFMRLDRIALVDFVAETYRVRAGIMFRQPPLSAVANIFAM--PFEN 387
            ::|::|.....:.|:|...:.:.|.|..::||......:...||.::|..|. ..:|:.  |...
Zfish   478 WNGMVGELVYGKADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSK-PGVFSFLDPLAY 541

  Fly   388 DVWVSILMLLIITTVVLVLELFFSPHN-HDMSYMD-------------TLNFVW---GAMCQQGF 435
            ::|:.|:...|..:|||.|...|||:. |...|.|             ..|.:|   ||..:||.
Zfish   542 EIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEYEDGQIQTNESTNEFGIFNSLWFSLGAFMRQGC 606

  Fly   436 YVEVRNRSARIIVFTTFVAALFLFTSFSANIVALLQ-----SPSDAIQSLSDLG-QSPLEIGVQD 494
            .:..|:.|.||:....:...|.:.:|::||:.|.|.     ||   |:|..||. |:.:..|..|
Zfish   607 DISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSP---IESAEDLAKQTEIAYGTLD 668

  Fly   495 TQYNKIYFTESTDPVTKNLYHKKIA--------SKG--ENIYMRPLL-GMEKMR--TGLFAYQVE 546
            :...|.:|..|           |||        .||  .:::::... |:.::|  .|.:||.:|
Zfish   669 SGSTKEFFRRS-----------KIALFDKMWTYMKGAEPSVFVKTTAEGVMRVRKSKGKYAYLLE 722

  Fly   547 LQAGYQIVSDTFSEPEKCGLMEL-EPFQLPMLAIPTRKNFPYKELIRRQLRWQREVSLVNREERK 610
                 ..:::...:.:.|..|:: .........|.|.|....:..:...:....|..|:::.:.|
Zfish   723 -----STMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRNAVNLAVLKLNEQGLLDKLKNK 782

  Fly   611 WIPQKPKCEGGVG 623
            |...|.:|..|.|
Zfish   783 WWYDKGECGSGGG 795

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir75d	NP_649074.2	Periplasmic_Binding_Protein_Type_2	299..>372	CDD:473866	17/76 (22%)
		Lig_chan	386..643	CDD:459656	65/275 (24%)
gria2b	XP_068069253.1	PBP1_iGluR_AMPA_GluR2	27..397	CDD:380612	57/306 (19%)
		PBP2_iGluR_AMPA	410..790	CDD:270433	88/400 (22%)