DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir75d and Grin2a

DIOPT Version :9

Sequence 1:	NP_649074.2	Gene:	Ir75d / 40065	FlyBaseID:	FBgn0036829	Length:	675	Species:	Drosophila melanogaster
Sequence 2:	NP_032196.2	Gene:	Grin2a / 14811	MGIID:	95820	Length:	1464	Species:	Mus musculus

Alignment Length:	743	Identity:	137/743 - (18%)
Similarity:	257/743 - (34%)	Gaps:	233/743 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 WQHFNL--------NNF--YVQVSTESSL--RDLQHVDALD-EHKDAPPP---KSFHAN------ 122
            |..|:|        .:|  :::.:.::|.  .|:|:|..|| ..:||...   |..|::
Mouse   167 WHVFSLVTTIFPGYRDFISFIKTTVDNSFVGWDMQNVITLDTSFEDAKTQVQLKKIHSSVILLYC 231

  Fly   123 ---------------NSTHWETSFLLPAL----------PYKMGILLL-----EFSSEC----AL 153
                           ..|.::..:::|:|          .:..|::.:     ::|.|.    .|
Mouse   232 SKDEAVLILSEARSLGLTGYDFFWIVPSLVSGNTELIPKEFPSGLISVSYDDWDYSLEARVRDGL 296

  Fly   154 NLLRWSAAS----------------------EHNYFTTNRFWLLLTEDPGDIDLLED-----PE- 190
            .:|..:|:|                      |....|.::|.:.:|.|..|:...|:     |.
Mouse   297 GILTTAASSMLEKFSYIPEAKASCYGQTEKPETPLHTLHQFMVNVTWDGKDLSFTEEGYQVHPRL 361

  Fly   191 --IFIPPDSELRVLHYENVGNFSCSLIDLYKVAAWKPLKRTLVGHNIRNSRHVIHALQHFGSAIT 253
              |.:..|.|     :|.||.:....:.| :.|.|...|..
Mouse   362 VVIVLNKDRE-----WEKVGKWENQTLSL-RHAVWPRYKSF------------------------ 396

  Fly   254 YRQDLEGIVFNSAIVIAFPDLFTNIEDLSLRHIDTIS--------------KVNHR--------- 295
              .|.|....:.:||......|..:||     ||.::              |:|:.
Mouse   397 --SDCEPDDNHLSIVTLEEAPFVIVED-----IDPLTETCVRNTVPCRKFVKINNSTNEGMNVKK 454

  Fly   296 --------LMLELANRLNMSYNTYQTVN--YGWRQPNGSFDGLMGR--FQRYELDLAQLAIFMRL 348
                    ::.:|:..:..:|:.|...|  :| ::.|..::|::|.  :||..:.:..|.|  ..
Mouse   455 CCKGFCIDILKKLSRTVKFTYDLYLVTNGKHG-KKVNNVWNGMIGEVVYQRAVMAVGSLTI--NE 516

  Fly   349 DRIALVDFVAETYRVRAGIMFRQPPLSAVANIFAMPFENDVWVSI-LMLLIITTVVLVLELFFS- 411
            :|..:|||..........:|..:...:...:.|..||...|||.: :||||::.:.:.:..:||
Mouse   517 ERSEVVDFSVPFVETGISVMVSRSNGTVSPSAFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSP 581

  Fly   412 ------------PHNHDMSYMDTLNFVWGAMCQQGFYVEVRN---RSARIIVFT-TFVAALFLFT 460
                        ||....:....:..:||.:....  |.|:|   .:::|:|.. .|.|.:|| .
Mouse   582 VGYNRNLAKGKAPHGPSFTIGKAIWLLWGLVFNNS--VPVQNPKGTTSKIMVSVWAFFAVIFL-A 643

  Fly   461 SFSANIVALL--QSPSDAIQSLSDLG-------QSPLEIGVQDTQYNKIYFTESTDPVTKNLY-- 514
            |::||:.|.:  :...|.:..|||..       ..|...|...        ..||:...:|.|
Mouse   644 SYTANLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVP--------NGSTERNIRNNYPY 700

  Fly   515 -HKKIASKGENIYMRPLLGMEKMRTGLFAYQVELQAGYQIVSDTFSEPEKCGLMELEP---FQLP 575
             |:.:....:......|:.::..:...|.|...: ..|:...|     |.|.|:.:..   |...
Mouse   701 MHQYMTKFNQRGVEDALVSLKTGKLDAFIYDAAV-LNYKAGRD-----EGCKLVTIGSGYIFATT 759

  Fly   576 MLAIPTRKNFPYKELIRRQLRWQREVSLV--------NREERKWIPQKPKCEGGVGGFVSIGITE 632
            ...|..:|..|          |:|::.|.        ..||.:.:.....|.......:|..:..
Mouse   760 GYGIALQKGSP----------WKRQIDLALLQFVGDGEMEELETLWLTGICHNEKNEVMSSQLDI 814

  Fly   633 CRYALGIF---GCGAAVSFVLFLFEFIF 657
            ...| |:|   ....|:|.:.|::|.:|
Mouse   815 DNMA-GVFYMLAAAMALSLITFIWEHLF 841

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75d	NP_649074.2	Periplasmic_Binding_Protein_Type_2	299..>483	CDD:304360	49/207 (24%)
Ir75d	NP_649074.2	Lig_chan	388..644	CDD:278489	59/299 (20%)
Grin2a	NP_032196.2	PBP1_iGluR_NMDA_NR2	32..392	CDD:107373	41/230 (18%)
		PBP2_iGluR_NMDA_Nr2	403..802	CDD:270436	84/433 (19%)
		HisJ	<458..>541	CDD:223904	17/85 (20%)
		Lig_chan	556..828	CDD:278489	59/299 (20%)
		NMDAR2_C	839..1464	CDD:287527	1/3 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846461
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930