DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir75d and Grik3

DIOPT Version :9

Sequence 1:	NP_649074.2	Gene:	Ir75d / 40065	FlyBaseID:	FBgn0036829	Length:	675	Species:	Drosophila melanogaster
Sequence 2:	NP_001074566.1	Gene:	Grik3 / 14807	MGIID:	95816	Length:	919	Species:	Mus musculus

Alignment Length:	684	Identity:	139/684 - (20%)
Similarity:	252/684 - (36%)	Gaps:	174/684 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 YRHHGVHSLMLVVCHTDIADFRLWKLWQHFNLNNFYVQVSTESSLRDLQHVDALDEHKDAPPPKS 118
            ||:.||          ::..||:      .|::|.:|....|..        |::..:.||..:|
Mouse   272 YRYSGV----------NLTGFRI------LNVDNPHVSAIVEKW--------AMERLQAAPRAES 312

  Fly   119 FHANNSTHWETSFLLPALP-----YKMGILLLEFSSECALNLLRWSAASEHNYFTTNRFWLLLTE 178
            ...:.....:.:.|..|:.     |:....:...|.:|..: ..|........|.....|..||
Mouse   313 GLLDGVMMTDAALLYDAVHIVSVCYQRAPQMTVNSLQCHRH-KAWRFGGRFMNFIKEAQWEGLT- 375

  Fly   179 DPGDIDLLEDPEIF-----IPPDSELRVLHYENVGNFSCSLIDLYKVAAWKP---LKRTLV---- 231
              |.|       :|     :..|.:|.::..:..|        |.||..|.|   |..|.|
Mouse   376 --GRI-------VFNKTSGLRTDFDLDIISLKEDG--------LEKVGVWSPADGLNITEVAKGR 423

  Fly   232 GHNIRNSRHVIHALQHFGSAITYRQDLEGIVFNSAIVIAFPDLFTNIED--LSLRHIDTISKVNH 294
            |.|:.:|                       :.|.::::.     |.:|:  :..|..|.....|.
Mouse   424 GPNVTDS-----------------------LTNRSLIVT-----TVLEEPFVMFRKSDRTLYGND 460

  Fly   295 R-------LMLELANRLNMSY--NTYQTVNYGWRQPNGSFDGLMGRFQRYELDLAQLAIFMRLDR 350
            |       |:.|||:.|..||  ...:...||.:...|.::|::.....::.|||...:.:...|
Mouse   461 RFEGYCIDLLKELAHILGFSYEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITHVR 525

  Fly   351 IALVDFVAETYRVRAGIMFRQPPLSAVANIFAM--PFENDVWVSILMLLIITTVVLVLELFFSPH 413
            ...:||......:...|::|:|. ....::|:.  |...|:|:.:|:..:..:.||.:...|||:
Mouse   526 EKAIDFSKPFMTLGVSILYRKPN-GTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPY 589

  Fly   414 ---------------NHDMSYMDTLNFVWGAMCQQGFYVEVRNRSARIIVFTTFVAALFLFTSFS 463
                           .::.:.:::..|..|::.|||..:..:..|.|||....:...|.:.:|::
Mouse   590 EWYDAHPCNPGSEVVENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYT 654

  Fly   464 ANIVALL-----QSPSDAIQSLSDLGQSPLEIGVQDTQYNKIYFTESTDPVTKNLYHKKIASKGE 523
            ||:.|.|     :||.|:...|:              :..||.:....|..|...:.|...|..|
Mouse   655 ANLAAFLTVERMESPIDSADDLA--------------KQTKIEYGAVKDGATMTFFKKSKISTFE 705

  Fly   524 NIY----MRPLLGMEKMRTGLFAYQVELQAGYQIVSDT----FSEPEKC------GLMELEPFQL 574
            .::    .:|...::....|:   |..|.|.|.::.::    :.....|      ||::.:.:
Mouse   706 KMWAFMSSKPSALVKNNEEGI---QRTLTADYALLMESTTIEYITQRNCNLTQIGGLIDSKGY-- 765

  Fly   575 PMLAIPTRKNFPYKELIR-RQLRWQREVSLVNREERKW----IPQKPKCEGGVGGFVSIGITECR 634
               .|.|....||::.|. ..|:.|.|..|...:|:.|    .|::...|....|...||
Mouse   766 ---GIGTPMGSPYRDKITIAILQLQEEDKLHIMKEKWWRGSGCPEEENKEASALGIQKIG----- 822

  Fly   635 YALGIF---GCGAAVSFVLFLFEFIFRHFKQVYR 665
               |||   ..|..:|.::.:.|||::..|...|
Mouse   823 ---GIFIVLAAGLVLSVLVAVGEFIYKLRKTAER 853

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75d	NP_649074.2	Periplasmic_Binding_Protein_Type_2	299..>483	CDD:304360	48/207 (23%)
Ir75d	NP_649074.2	Lig_chan	388..644	CDD:278489	62/297 (21%)
Grik3	NP_001074566.1	PBP1_iGluR_Kainate_GluR5_7	34..417	CDD:107388	36/187 (19%)
		PBP2_iGluR_Kainate_GluR7	433..801	CDD:270441	82/395 (21%)
		Glutamate binding. /evidence=ECO:0000250	690..692		0/1 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846540
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740