DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir75d and Grik1

DIOPT Version :9

Sequence 1:	NP_649074.2	Gene:	Ir75d / 40065	FlyBaseID:	FBgn0036829	Length:	675	Species:	Drosophila melanogaster
Sequence 2:	XP_006522977.1	Gene:	Grik1 / 14805	MGIID:	95814	Length:	949	Species:	Mus musculus

Alignment Length:	672	Identity:	137/672 - (20%)
Similarity:	254/672 - (37%)	Gaps:	142/672 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 YRHHGVHSLMLVVCHTDIADFRLWKLWQHFNLNNFYVQVSTES-SLRDLQHVDALDEHKDAPP-P 116
            ||:.||          ::..|||      .|::|.:|....|. |:..||          ||| |
Mouse   270 YRYSGV----------NMTGFRL------LNIDNPHVSSIIEKWSMERLQ----------APPRP 308

  Fly   117 KSFHANNSTHWETSFLLPALPYKMGIL------LLEFSSEC-----------ALNLL---RWSAA 161
            ::...:.....|.:.:..|: |.:.|.      |...|.:|           .:||:   ||..
Mouse   309 ETGLLDGVMTTEAALMYDAV-YMVAIASHRASQLTVSSLQCHRHKPWRLGPRFMNLIKEARWDG- 371

  Fly   162 SEHNYFTTNRFWLLLTEDPGDIDLLEDPEIFIPPDSELRVLHYENVGNFSCS---LIDLYKVAAW 223
                  .|.|.....|:.             :..|.:|.::..:..|....|   ...||||  |
Mouse   372 ------LTGRITFNKTDG-------------LRKDFDLDIISLKEEGTEKASGEVSKHLYKV--W 415

  Fly   224 KPL-------KRTLVGHNIRNSRHVIHALQHFGSAITYRQDLEGIVFNSAIVIAFPDLFTNIEDL 281
            |.:       ...:...|...|.::..:|.:....:|             .::..|.:.....|.
Mouse   416 KKIGIWNSNSGLNMTDGNRDRSNNITDSLANRTLIVT-------------TILEEPYVMYRKSDK 467

  Fly   282 SLRHIDTISKVNHRLMLELANRLNMSYNTYQTVN--YGWRQPNGSFDGLMGRFQRYELDLAQLAI 344
            .|...|........|:.||:|.|...|:.....:  ||.:...|.::|::.....:..|||...:
Mouse   468 PLYGNDRFEGYCLDLLKELSNILGFLYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPL 532

  Fly   345 FMRLDRIALVDFVAETYRVRAGIMFRQPPLSAVANIFAM--PFENDVWVSILMLLI-ITTVVLVL 406
            .:...|..::||......:...|::|:|. .....:|:.  |...|:|:.:|:..: ::.|:.|:
Mouse   533 TITYVREKVIDFSKPFMTLGISILYRKPN-GTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVI 596

  Fly   407 ELF-----FSPH--NHDMSYMDT----LNFVW---GAMCQQGFYVEVRNRSARIIVFTTFVAALF 457
            ..|     ::||  |.|...::.    ||..|   ||:.|||..:..:..|.||:....:...|.
Mouse   597 ARFTPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLI 661

  Fly   458 LFTSFSANIVALL-----QSPSDAIQSLSDLGQSPLEIGVQDTQYNKIYFTESTDPVTKNLYHKK 517
            :.:|::||:.|.|     :||.|:...|:.  |:.:|.|.........:|.:|.....:.::...
Mouse   662 IISSYTANLAAFLTVERMESPIDSADDLAK--QTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFM 724

  Fly   518 IASKGENIYMRPLLGMEKMRTGLFAYQVELQAGYQIVSDTFSEPEKCGLMELEPFQLPMLAIPTR 582
            .:.:...:......|::::.|..:|..:|..:...:.....:..:..||::.:.:     .:.|.
Mouse   725 SSRQQSALVKNSDEGIQRVLTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGY-----GVGTP 784

  Fly   583 KNFPYKELIR-RQLRWQREVSLVNREERKW----IPQKPKCEGGVGGFVSIGITECRYALGIF-- 640
            ...||::.|. ..|:.|.|..|...:|:.|    .|::...|....|..:||        |||
Mouse   785 IGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEDSKEASALGVENIG--------GIFIV 841

  Fly   641 -GCGAAVSFVLFLFEFIFRHFK 661
             ..|..:|..:.:.|||::..|
Mouse   842 LAAGLVLSVFVAIGEFIYKSRK 863

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75d	NP_649074.2	Periplasmic_Binding_Protein_Type_2	299..>483	CDD:304360	51/207 (25%)
Ir75d	NP_649074.2	Lig_chan	388..644	CDD:278489	60/283 (21%)
Grik1	XP_006522977.1	PBP1_iGluR_Kainate	38..431	CDD:380605	42/209 (20%)
Grik1	XP_006522977.1	Periplasmic_Binding_Protein_Type_2	446..815	CDD:389745	77/389 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846531
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740