Protein Alignment Ir75d and Grik1

DIOPT Version :10

• Sequence 1: NP_649074.2
• Gene: Ir75d / 40065
• FlyBaseID: FBgn0036829
• Length: 675
• Species: Drosophila melanogaster
• Sequence 2: NP_001391957.1
• Gene: Grik1 / 14805
• MGIID: 95814
• Length: 949
• Species: Mus musculus
• Alignment Length: 672
• Identity: 137/672 - (20%)
• Similarity: 254/672 - (37%)
• Gaps: 142/672 - (21%)

  Fly    54 YRHHGVHSLMLVVCHTDIADFRLWKLWQHFNLNNFYVQVSTES-SLRDLQHVDALDEHKDAPP-P 116
            ||:.||          ::..|||      .|::|.:|....|. |:..||          ||| |
Mouse   270 YRYSGV----------NMTGFRL------LNIDNPHVSSIIEKWSMERLQ----------APPRP 308

  Fly   117 KSFHANNSTHWETSFLLPALPYKMGIL------LLEFSSEC-----------ALNLL---RWSAA 161
            ::...:.....|.:.:..|: |.:.|.      |...|.:|           .:||:   ||..
Mouse   309 ETGLLDGVMTTEAALMYDAV-YMVAIASHRASQLTVSSLQCHRHKPWRLGPRFMNLIKEARWDG- 371

  Fly   162 SEHNYFTTNRFWLLLTEDPGDIDLLEDPEIFIPPDSELRVLHYENVGNFSCS---LIDLYKVAAW 223
                  .|.|.....|:.             :..|.:|.::..:..|....|   ...||||  |
Mouse   372 ------LTGRITFNKTDG-------------LRKDFDLDIISLKEEGTEKASGEVSKHLYKV--W 415

  Fly   224 KPL-------KRTLVGHNIRNSRHVIHALQHFGSAITYRQDLEGIVFNSAIVIAFPDLFTNIEDL 281
            |.:       ...:...|...|.::..:|.:....:|             .::..|.:.....|.
Mouse   416 KKIGIWNSNSGLNMTDGNRDRSNNITDSLANRTLIVT-------------TILEEPYVMYRKSDK 467

  Fly   282 SLRHIDTISKVNHRLMLELANRLNMSYNTYQTVN--YGWRQPNGSFDGLMGRFQRYELDLAQLAI 344
            .|...|........|:.||:|.|...|:.....:  ||.:...|.::|::.....:..|||...:
Mouse   468 PLYGNDRFEGYCLDLLKELSNILGFLYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPL 532

  Fly   345 FMRLDRIALVDFVAETYRVRAGIMFRQPPLSAVANIFAM--PFENDVWVSILMLLI-ITTVVLVL 406
            .:...|..::||......:...|::|:|. .....:|:.  |...|:|:.:|:..: ::.|:.|:
Mouse   533 TITYVREKVIDFSKPFMTLGISILYRKPN-GTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVI 596

  Fly   407 ELF-----FSPH--NHDMSYMDT----LNFVW---GAMCQQGFYVEVRNRSARIIVFTTFVAALF 457
            ..|     ::||  |.|...::.    ||..|   ||:.|||..:..:..|.||:....:...|.
Mouse   597 ARFTPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLI 661

  Fly   458 LFTSFSANIVALL-----QSPSDAIQSLSDLGQSPLEIGVQDTQYNKIYFTESTDPVTKNLYHKK 517
            :.:|::||:.|.|     :||.|:...|:.  |:.:|.|.........:|.:|.....:.::...
Mouse   662 IISSYTANLAAFLTVERMESPIDSADDLAK--QTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFM 724

  Fly   518 IASKGENIYMRPLLGMEKMRTGLFAYQVELQAGYQIVSDTFSEPEKCGLMELEPFQLPMLAIPTR 582
            .:.:...:......|::::.|..:|..:|..:...:.....:..:..||::.:.:     .:.|.
Mouse   725 SSRQQSALVKNSDEGIQRVLTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGY-----GVGTP 784

  Fly   583 KNFPYKELIR-RQLRWQREVSLVNREERKW----IPQKPKCEGGVGGFVSIGITECRYALGIF-- 640
            ...||::.|. ..|:.|.|..|...:|:.|    .|::...|....|..:||        |||
Mouse   785 IGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEDSKEASALGVENIG--------GIFIV 841

  Fly   641 -GCGAAVSFVLFLFEFIFRHFK 661
             ..|..:|..:.:.|||::..|
Mouse   842 LAAGLVLSVFVAIGEFIYKSRK 863

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir75d	NP_649074.2	Periplasmic_Binding_Protein_Type_2	299..>372	CDD:473866	17/74 (23%)
		Lig_chan	386..643	CDD:459656	60/284 (21%)
Grik1	NP_001391957.1	PBP1_iGluR_Kainate	38..431	CDD:380605	42/209 (20%)
		Periplasmic_Binding_Protein_Type_2	446..815	CDD:473866	77/389 (20%)