DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir75d and Grid2

DIOPT Version :9

Sequence 1:	NP_649074.2	Gene:	Ir75d / 40065	FlyBaseID:	FBgn0036829	Length:	675	Species:	Drosophila melanogaster
Sequence 2:	NP_032193.1	Gene:	Grid2 / 14804	MGIID:	95813	Length:	1007	Species:	Mus musculus

Alignment Length:	632	Identity:	121/632 - (19%)
Similarity:	242/632 - (38%)	Gaps:	165/632 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 QHFNLNNFYVQVSTESSLRDLQHVDALDEHKDAPPPKSFHANNSTHWETSFLLPAL-----PYKM 140
            |:..::|.|: ..|...|.:..| ..|::.|               |.:...|..:     |::.
Mouse   318 QNMEISNLYI-YDTVLLLANAFH-KKLEDRK---------------WHSMASLSCIRKNSKPWQG 365

  Fly   141 GILLLEFSSECALNLLRWSAASEHNYFTTNRFWLLLTEDPGDIDLLE---DPEIFIPPDSELRVL 202
            |..:||...:..:|.|                       .||::..|   :|.:
Mouse   366 GRSMLETIKKGGVNGL-----------------------TGDLEFGENGGNPNV----------- 396

  Fly   203 HYENVG-NFSCSL-IDLYKVAAWKP---LKRTLVGHNIRNSRHVIHALQHFGSAITYRQDLEGIV 262
            |:|.:| |:...| ..:.|:..|.|   |..:|....:.|                   ::.|:|
Mouse   397 HFEILGTNYGEELGRGVRKLGCWNPVTGLNGSLTDKKLEN-------------------NMRGVV 442

  Fly   263 FNSAIVIAFPDLFTN---------IEDLSLRHIDTISKVNHRLMLELANRLNMSYNTYQTVN--Y 316
            .....|:..|.:..:         .:..|:..:|.:|           |.|..:|..|...:  |
Mouse   443 LRVVTVLEEPFVMVSENVLGKPKKYQGFSIDVLDALS-----------NYLGFNYEIYVAPDHKY 496

  Fly   317 GWRQPNGSFDGLMGR--FQRYELDLAQLAIFMRLDRIALVDFVAETYRVRAGIMFRQPPLSAVAN 379
            |..|.:|:::||:|.  |:|.::.::.|.|  ..||..:|||.........|::.|:  .....:
Mouse   497 GSPQEDGTWNGLVGELVFKRADIGISALTI--TPDRENVVDFTTRYMDYSVGVLLRR--AEKTVD 557

  Fly   380 IFA--MPFENDVWVSILMLLIITTVVLVLELFFSPHNHDMSYM------DTLNFVWGAMCQQGFY 436
            :||  .||:..:|..|...:::..:::.|..:.:|....|..|      :::.||:|:..|||..
Mouse   558 MFACLAPFDLSLWACIAGTVLLVGLLVYLLNWLNPPRLQMGSMTSTTLYNSMWFVYGSFVQQGGE 622

  Fly   437 VEVRNRSARIIVFTTFVAALFLFTSFSANIVALLQSP--SDAIQSLSDLG-QSPLEIG-VQDTQY 497
            |.....:.|:::...::.||.:.:|::||:.|.|...  ..:||||.||. |:.:..| |.|:..
Mouse   623 VPYTTLATRMMMGAWWLFALIVISSYTANLAAFLTITRIESSIQSLQDLSKQTDIPYGTVLDSAV 687

  Fly   498 NKIYFTESTDPVTKNLYHKKI------ASKGENIYMRPLLGMEKMRTGLFAYQVEL--------- 547
            .:....:..:|..::..:.::      ::..||..:....|::|::.|.:|:..:.
Mouse   688 YQHVRMKGLNPFERDSMYSQMWRMINRSNGSENNVLESQAGIQKVKYGNYAFVWDAAVLEYVAIN 752

  Fly   548 --QAGYQIVSDTFSEPEKCGLMELEPFQLPMLAIPTRKNFPYKELIRRQLRWQREVSLVNREERK 610
              ...:..|.:|.::..              ..|..:...||:::..:::...::...::..:.|
Mouse   753 DPDCSFYTVGNTVADRG--------------YGIALQHGSPYRDVFSQRILELQQSGDMDILKHK 803

  Fly   611 WIPQKPKCE----------GGVGGFVSIGITECRYALGI-FGCGAAV 646
            |.|:..:|:          ||.....|:....|..|.|| ..|..||
Mouse   804 WWPKNGQCDLYSSVDAKQKGGALDIKSLAGVFCILAAGIVLSCLIAV 850

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75d	NP_649074.2	Periplasmic_Binding_Protein_Type_2	299..>483	CDD:304360	51/197 (26%)
Ir75d	NP_649074.2	Lig_chan	388..644	CDD:278489	55/293 (19%)
Grid2	NP_032193.1	Interaction with CBLN1 homotrimer. /evidence=ECO:0000250\|UniProtKB:O43424	24..345		7/28 (25%)
		Periplasmic_Binding_Protein_type1	28..429	CDD:385651	29/161 (18%)
		PBP2_iGluR_delta_2	440..806	CDD:270449	78/394 (20%)
		Interaction with AP4M1. /evidence=ECO:0000250\|UniProtKB:Q63226	921..991
		PDZ-binding	1005..1007
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846496
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740