Protein Alignment Ir75d and Gria2

DIOPT Version :10

• Sequence 1: NP_649074.2
• Gene: Ir75d / 40065
• FlyBaseID: FBgn0036829
• Length: 675
• Species: Drosophila melanogaster
• Sequence 2: NP_001344853.2
• Gene: Gria2 / 14800
• MGIID: 95809
• Length: 901
• Species: Mus musculus
• Alignment Length: 783
• Identity: 152/783 - (19%)
• Similarity: 277/783 - (35%)
• Gaps: 229/783 - (29%)

  Fly    47 PDM------LVAYYR----------HHGVHSLMLVVCHTDIADFRLWKLWQHF-----NLNNFYV 90
            ||:      |:.||:          ..|:.:|..|:      |....|.||..     |:||...
Mouse   130 PDLKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAVL------DSAAEKKWQVTAINVGNINNDKK 188

  Fly    91 QVSTESSLRDLQ---------------------HVDALDEHKDAPPPKSFHANNSTHWETSFLLP 134
            ..:..|..:||:                     .|..:.:|     .|.:|          :::.
Mouse   189 DETYRSLFQDLELKKERRVILDCERDKVNDIVDQVITIGKH-----VKGYH----------YIIA 238

  Fly   135 ALPYKMGILL-LEF--------------SSECALNLLRWSAASEHNY----FTTNRFWLLLTEDP 180
            .|.:..|.|| ::|              .|..:..:.|||...|..|    ..|.::...||.|.
Mouse   239 NLGFTDGDLLKIQFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYPGAHTATIKYTSALTYDA 303

  Fly   181 GDI----------------------DLLEDPEI----FIPPDSELRVLHYENVG----------- 208
            ..:                      |.|.:|.:    .:..:..|:.:..|.:.
Mouse   304 VQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKR 368

  Fly   209 -NFSCSLIDL-----YKVAAWKPLKRTLVGHNIRNSRHVIHALQHFGSAITYRQDLEGIVFNSAI 267
             |::.::::|     .|:..|..:.:.:|            .|....|.    .|..|:. |..:
Mouse   369 INYTINIMELKTNGPRKIGYWSEVDKMVV------------TLTELPSG----NDTSGLE-NKTV 416

  Fly   268 VIAFPDLFTNIEDLSLRHIDTISKVNHRLM--------------LELANRLNMSYNTYQTV---- 314
            |:      |.|    |.....:.|.||.::              .|:|......|..  |:
Mouse   417 VV------TTI----LESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKL--TIVGDG 469

  Fly   315 NYGWRQPNGS-FDGLMGRFQRYELDLAQLAIFMRLDRIALVDFVAETYRVRAGIMFRQPPLSAVA 378
            .||.|..:.. ::|::|.....:.|:|...:.:.|.|..::||......:...||.::|..|. .
Mouse   470 KYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSK-P 533

  Fly   379 NIFAM--PFENDVWVSILMLLIITTVVLVLELFFSPHN-HDMSYMD--------------TLNFV 426
            .:|:.  |...::|:.|:...|..:|||.|...|||:. |...:.|              ..|.:
Mouse   534 GVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSL 598

  Fly   427 W---GAMCQQGFYVEVRNRSARIIVFTTFVAALFLFTSFSANIVALLQ-----SPSDAIQSLSDL 483
            |   ||..|||..:..|:.|.||:....:...|.:.:|::||:.|.|.     ||.::.:.||.
Mouse   599 WFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSK- 662

  Fly   484 GQSPLEIGVQDTQYNKIYFTESTDPVTKNLYHKKIASKGENIYMRPLL-GMEKMR--TGLFAYQV 545
             |:.:..|..|:...|.:|..|...|...:: ..:.|...::::|... |:.::|  .|.:||.:
Mouse   663 -QTEIAYGTLDSGSTKEFFRRSKIAVFDKMW-TYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLL 725

  Fly   546 ELQAGYQIVSDTFSEPEKCGLMEL-EPFQLPMLAIPTRKNFPYKELIRRQLRWQREVSLVNREER 609
            |     ..:::...:.:.|..|:: .........|.|.|....:..:...:....|..::::.:.
Mouse   726 E-----STMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRTPVNLAVLKLSEQGVLDKLKN 785

  Fly   610 KWIPQKPKCEGGVGGFVSIGITECRYAL------GIF-----GCGAAVSFVLFLFEFIFRHFKQV 663
            ||...|.:|     |....|..|...||      |:|     |.|.|:  ::.|.||.::...:.
Mouse   786 KWWYDKGEC-----GAKDSGSKEKTSALSLSNVAGVFYILVGGLGLAM--LVALIEFCYKSRAEA 843

  Fly   664 YRI 666
            .|:
Mouse   844 KRM 846

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir75d	NP_649074.2	Periplasmic_Binding_Protein_Type_2	299..>372	CDD:473866	17/77 (22%)
		Lig_chan	386..643	CDD:459656	66/294 (22%)
Gria2	NP_001344853.2	PBP1_iGluR_AMPA_GluR2	28..398	CDD:380612	47/300 (16%)
		PBP2_iGluR_AMPA	413..794	CDD:270433	86/401 (21%)