Protein Alignment Ir75d and Grik4

DIOPT Version :10

• Sequence 1: NP_649074.2
• Gene: Ir75d / 40065
• FlyBaseID: FBgn0036829
• Length: 675
• Species: Drosophila melanogaster
• Sequence 2: NP_780690.2
• Gene: Grik4 / 110637
• MGIID: 95817
• Length: 956
• Species: Mus musculus
• Alignment Length: 743
• Identity: 155/743 - (20%)
• Similarity: 283/743 - (38%)
• Gaps: 221/743 - (29%)

  Fly    65 VVCHTDIADFRLWKLWQHFNLNNFYVQVSTESSLRDLQHVDALDEHKDAPP-------PKS---- 118
            ::|........|.||.:.|.::            :|...|..||:.:|..|       .|:
Mouse   164 LICAKAECLLNLEKLLRQFLIS------------KDTLSVRMLDDTRDPTPLLKEIRDDKTATII 216

  Fly   119 FHANNS-THWETSFLLPALPYKMGILL---------LEFS-------SECALNLLRWSAASE-HN 165
            .|||.| :|   :.||.|.  ::|::.         ||||       .:..:|:|.:|..:: |.
Mouse   217 IHANASMSH---TILLKAA--ELGMVSAYYTYIFTNLEFSLQRMDSLVDDRVNILGFSIFNQSHA 276

  Fly   166 YF-----TTNRFWLLLTED----PGDIDLLEDPEIF------IPPDSELRVLHYENVGNFSC--- 212
            :|     :.|:.|   .|:    |.....|....:|      :....||.......|...||
Mouse   277 FFQEFSQSLNQSW---QENCDHVPFTGPALSSALLFDAVYAVVTAVQELNRSQEIGVKPLSCGSA 338

  Fly   213 -------SLIDLYKVAAWKPLKRTLVGHNIRNSR-----HVIHALQ------------HFGSAIT 253
                   ||::..::...:    .|.||...||:     :.:..||            |....::
Mouse   339 QIWQHGTSLMNYLRMVELE----GLTGHIEFNSKGQRSNYALKILQFTRNGFQQIGQWHVAEGLS 399

  Fly   254 -----YRQDLEGIVFNSAIVIAFPDLFTNIEDLSLRHIDTISKVNHR--------------LMLE 299
                 |..::...:||:.:|:.     |.:|:..|     :.|.||:              ::.|
Mouse   400 MDSRLYASNISDSLFNTTLVVT-----TILENPYL-----MLKGNHQEMEGNDRYEGFCVDMLKE 454

  Fly   300 LANRLNMSYNTYQTVN--YGWRQPNGSFDGLMGRFQRYELDLAQLAIFMRLDRIALVDF------ 356
            ||..|..:|......:  ||..:.||::.|::|.....:.|||...:.:..:|..::||
Mouse   455 LAEILRFNYKIRLVGDGVYGVPEANGTWTGMVGELIARKADLAVAGLTITAEREKVIDFSKPFMT 519

  Fly   357 --VAETYRVRAGIMFRQPPLSAVANIFAMPFENDVWVSILMLLIITTVVLVLEL------FFSPH 413
              ::..|||..|   |:|...:    |..||...||:.:|:..:..:.||.|..      ::|||
Mouse   520 LGISILYRVHMG---RRPGYFS----FLDPFSPGVWLFMLLAYLAVSCVLFLVARLTPYEWYSPH 577

  Fly   414 N----------HDMSYMDTLNFVWGAMCQQGFYVEVRNRSARIIVFTTFVAALFLFTSFSANIVA 468
            .          :..|..::|.|..|...|||..:..|..|.|.:....:...|.:.:|::||:.|
Mouse   578 PCAQGRCNLLVNQYSLGNSLWFPVGGFMQQGSTIAPRALSTRCVSGVWWAFTLIIISSYTANLAA 642

  Fly   469 LL-----QSPSDAIQSLSDLGQSPLEIGVQDTQYNKIYFTESTDPVTKNLYHKKIASKGENIYMR 528
            .|     :.|.:::..|:|  |:.:|.|......:..:|..|.....:.::: .:.||..:::::
Mouse   643 FLTVQRMEVPIESVDDLAD--QTAIEYGTIHGGSSMTFFQNSRYQTYQRMWN-YMYSKQPSVFVK 704

  Fly   529 PL-LGMEKMRTGLFAYQVELQAGYQIVSDTFSE---PEKC------GLMELEPFQLPM-LAIPTR 582
            .. .|:.::....:|:.:|         .|.:|   ...|      ||::.:.:.:.| :....|
Mouse   705 STEEGIARVLNSNYAFLLE---------STMNEYYRQRNCNLTQIGGLLDTKGYGIGMPVGSVFR 760

  Fly   583 KNFPYKELIRRQLRWQREVSLVNREERKWIPQKPKCEGGVG-----------GFVSIGITECRYA 636
            ..|   :|...||:....:.::   :|||      .|||..           |..:||
Mouse   761 DEF---DLAILQLQENNRLEIL---KRKW------WEGGKCPKEEDHRAKGLGMENIG------- 806

  Fly   637 LGIFG---CGAAVSFVLFLFEFIF--RH 659
             |||.   ||..|:..:.:.||::  ||
Mouse   807 -GIFVVLICGLIVAIFMAMLEFLWTLRH 833

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir75d	NP_649074.2	Periplasmic_Binding_Protein_Type_2	299..>372	CDD:473866	22/82 (27%)
		Lig_chan	386..643	CDD:459656	61/302 (20%)
Grik4	NP_780690.2	Periplasmic_Binding_Protein_type1	24..402	CDD:471960	51/261 (20%)
		PBP2_iGluR_kainate_KA1	415..785	CDD:270442	86/410 (21%)
		QRL_CxxC_CxxC	863..927	CDD:469521
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	931..956