DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir75d and LOC110438919

DIOPT Version :9

Sequence 1:	NP_649074.2	Gene:	Ir75d / 40065	FlyBaseID:	FBgn0036829	Length:	675	Species:	Drosophila melanogaster
Sequence 2:	XP_021328141.1	Gene:	LOC110438919 / 110438919	-ID:	-	Length:	1417	Species:	Danio rerio

Alignment Length:	656	Identity:	129/656 - (19%)
Similarity:	225/656 - (34%)	Gaps:	196/656 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 VQVSTESSLRDL-QHVDALDEHKDAPPPKSFHANNSTHWETSFLLPALPYKMGILL----LEFSS 149
            :..:|.:.:.|. .|.....|...||..||....|:..        .|.|.|.:..    |.||.
Zfish   159 IATATSTMMMDRGPHTLLKSECHGAPDKKSPMTGNNNE--------VLRYLMNVTFEGRNLSFSE 215

  Fly   150 E-------CALNLL----------RWSAAS-EHNYFTTNRFWLLLTEDPGDIDLLEDPEIFIPPD 196
            :       ..:.||          :|...| ...|....||           :|...||  ...|
Zfish   216 DGYQMHPKLVIILLDKERQWDRVGKWENGSLSMKYHVWPRF-----------ELYSGPE--ARED 267

  Fly   197 SELRVLHYENVGNFSCSLIDLYKVAAWKPLKRTLVGHNIRNS---RHVIHAL-QHFGSAITYRQD 257
            ..|.::..|.........:|        ||..|.    :||:   |..:.|| |...||:..::.
Zfish   268 DHLSIVTLEEAPFVIVEDVD--------PLSGTC----MRNTVPCRKQLKALNQTQDSAVYIKRC 320

  Fly   258 LEGIVFNSAIVIAFPDLFTNIEDLSLRHIDTISKVNHRLMLELANRLNMSYNTYQTVN--YGWRQ 320
            .:|..                       ||.:.|:        |..:..:|:.|...|  :| ::
Zfish   321 CKGFC-----------------------IDILKKI--------AKNVKFTYDLYLVTNGKHG-KK 353

  Fly   321 PNGSFDGLMGRFQRYELDLAQLAIFMRLDRIALVDFVAETYRVRAGIMFRQPPLSAVANIFAMPF 385
            .||:::|::|........:|..::.:..:|..::||..........:|..:...:...:.|..||
Zfish   354 INGTWNGMVGEVVLKNAHMAVGSLTINEERSEVIDFSVPFIETGISVMVSRSNGTVSPSAFLEPF 418

  Fly   386 ENDVWVSI-LMLLIITTVVLVLELFFSPHNHDMSYMD-------------TLNFVWGAMCQQGFY 436
            ..|||:.: :|||:::.:.:.:..:|||..::....|             .:..:||.:......
Zfish   419 SADVWIMMFVMLLLVSAIAVFIFEYFSPVGYNRCLADGREAGGPSFTIGKAIWLLWGLVFNNSVP 483

  Fly   437 VE-VRNRSARIIVFT-TFVAALFLFTSFSANIVALL--QSPSDAIQSLSDLG-------QSPLEI 490
            |: .|..:::|:|.. .|.|.:|| .|::||:.|.:  :...|.:..|||..       ..|...
Zfish   484 VQNPRGTTSKIMVSVWAFFAVIFL-ASYTANLAAFMIQEEYVDQVSGLSDKKFQNPNDFSPPFRF 547

  Fly   491 GVQDTQYNKIYFTESTDPVTKNLYHKKIASKGENIYMRPLL-GMEKMRTG---LFAYQVELQAGY 551
            |...        ..||:...:|.| :.:.|.....:.|.:: .:|.::||   .|.|...: ..|
Zfish   548 GTVP--------NGSTERNIRNNY-RDMHSYMVKFHQRNVVEALESLKTGKLDAFIYDAAV-LNY 602

  Fly   552 QIVSDTFSEPEKCGLMELEPFQLPMLAIPTRKNFP---YKELIRRQLRWQREVSL---------- 603
            ....|     |.|.|          :.|.:.|.|.   |...|::...|:|:|.|
Zfish   603 MAGRD-----EGCKL----------VTIGSGKVFASTGYGIAIQKDSGWKRQVDLAILQLFGDGE 652

  Fly   604 VNREERKWIPQKPKCEGGVGGFVSIGITECRY--------------ALGIF---GCGAAVSFVLF 651
            :...|..|:               .||  |.:              ..|:|   |...|:|.:.|
Zfish   653 MEELEALWL---------------TGI--CHHEKNEVMSSQLDVDNMAGVFYMLGAAMALSLITF 700

  Fly   652 LFEFIF 657
            :.|.:|
Zfish   701 IAEHVF 706

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75d	NP_649074.2	Periplasmic_Binding_Protein_Type_2	299..>483	CDD:304360	44/203 (22%)
Ir75d	NP_649074.2	Lig_chan	388..644	CDD:278489	63/314 (20%)
LOC110438919	XP_021328141.1	PBP1_iGluR_NMDA_NR2	<1..255	CDD:107373	20/103 (19%)
		PBP2_iGluR_NMDA_Nr2	267..667	CDD:270436	96/486 (20%)
		DUF4013	<389..478	CDD:315788	17/88 (19%)
		NMDAR2_C	704..1417	CDD:313729	1/3 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591405
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.830