DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir75d and grin2b

DIOPT Version :9

Sequence 1:	NP_649074.2	Gene:	Ir75d / 40065	FlyBaseID:	FBgn0036829	Length:	675	Species:	Drosophila melanogaster
Sequence 2:	XP_017948700.2	Gene:	grin2b / 100490580	XenbaseID:	XB-GENE-949327	Length:	1449	Species:	Xenopus tropicalis

Alignment Length:	433	Identity:	92/433 - (21%)
Similarity:	162/433 - (37%)	Gaps:	105/433 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   286 IDTISKVNHRLMLELANRLNMSYNTYQTVN--YGWRQPNGSFDGLMGRFQRYELDLAQLAIFMRL 348
            ||.:.|:        |..:..:|:.|...|  :| ::.||:::|::|........:|..::.:..
Frog   459 IDILKKI--------AKTVKFTYDLYLVTNGKHG-KKINGTWNGMIGEVVTKRAYMAVGSLTINE 514

  Fly   349 DRIALVDFVAETYRVRAGIMFRQPPLSAVANIFAMPFENDVWVSI-LMLLIITTVVLVLELFFSP 412
            :|..:|||..........:|..:...:...:.|..||..||||.: :||||::.|.:.:..:|||
Frog   515 ERSEVVDFSVPFIETGISVMVSRSNGTVSPSAFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSP 579

  Fly   413 HNHDMSYMD-------------TLNFVWGAMCQQGFYVEVRN---RSARIIVFT-TFVAALFLFT 460
            ..::....|             .:..:||.:....  |.|:|   .:::|:|.. .|.|.:|| .
Frog   580 VGYNRCLADGREPGGPSFTIGKAIWLLWGLVFNNS--VPVQNPKGTTSKIMVSVWAFFAVIFL-A 641

  Fly   461 SFSANIVALL--QSPSDAIQSLSD--------------LGQSPLEIGVQDTQYNKIYFTESTDPV 509
            |::||:.|.:  :...|.:..|||              .|..|               ..||:..
Frog   642 SYTANLAAFMIQEEYVDQVSGLSDKKFQRPNDFSPAFRFGTVP---------------NGSTERN 691

  Fly   510 TKNLY---HKKIASKGENIYMRPLLGMEKMRTGLFAYQVELQAGYQIVSDTFSEPEKCGLMELEP 571
            .:|.|   |..:....:......||.::..:...|.|...: ..|....|     |.|.|
Frog   692 IRNNYLEMHSYMVKFNQRSVQDALLSLKTGKLDAFIYDAAV-LNYMAGRD-----EGCKL----- 745

  Fly   572 FQLPMLAIPTRKNFP---YKELIRRQLRWQREVSL----------VNREERKWIPQKPKCEGGVG 623
                 :.|.:.|.|.   |...|::...|:|:|.|          :...|..|:  ...|.....
Frog   746 -----VTIGSGKVFATTGYGIAIQKDSGWKRQVDLAILQLFGDGEMEELEALWL--TGICHNEKN 803

  Fly   624 GFVSIGITECRYALGIF---GCGAAVSFVLFLFEFIF----RH 659
            ..:|..:.....| |:|   ....|:|.:.|:.|.:|    ||
Frog   804 EVMSSQLDIDNMA-GVFYMLAAAMALSLITFIMEHLFFWQLRH 845

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75d	NP_649074.2	Periplasmic_Binding_Protein_Type_2	299..>483	CDD:304360	50/219 (23%)
Ir75d	NP_649074.2	Lig_chan	388..644	CDD:278489	64/308 (21%)
grin2b	XP_017948700.2	PBP1_iGluR_NMDA_NR2	28..383	CDD:380601
		PBP2_iGluR_NMDA_Nr2	400..800	CDD:270436	81/385 (21%)
		NMDAR2_C	837..1449	CDD:402274	3/9 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910