DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir75d and LOC100149482

DIOPT Version :9

Sequence 1:	NP_649074.2	Gene:	Ir75d / 40065	FlyBaseID:	FBgn0036829	Length:	675	Species:	Drosophila melanogaster
Sequence 2:	XP_009290417.1	Gene:	LOC100149482 / 100149482	-ID:	-	Length:	1959	Species:	Danio rerio

Alignment Length:	714	Identity:	133/714 - (18%)
Similarity:	224/714 - (31%)	Gaps:	283/714 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 LPALPYKMGILLLEFSSECALNL---------LRWSAAS-----EHNY---------FTTNRF-- 172
            |..:|.:.|.:.|:|||..||.|         ..|:|.|     .|.|         .|...|
Zfish   161 LGRVPQESGSIFLQFSSSTALQLEVIFEVLEEYDWTAFSVVSTRHHGYQDFLSVVEGLTDGSFIG 225

  Fly   173 W-------LLLTEDPGDI---DLLEDPEIFIPPDSELRVLHYENVGNFSCSLIDLYKV--AAW-- 223
            |       |.||:|||.:   .||::.|      :::|:|:        ||..:..:|  |||
Zfish   226 WEKKSIVMLNLTDDPGGVRTQRLLKENE------AQVRLLY--------CSQEEAEQVFLAAWAA 276

  Fly   224 --------------------------------------KPLKRTLVGHNI--------------- 235
                                                  :|.:|...|.:|
Zfish   277 GQAGASHIWFAVGPALSELGLTGLPKRLFAVRPQGWRDEPRRRIARGVSILTHGAVALRKDYGAT 341

  Fly   236 ------------RNSRHVIHALQHFGSAIT-----YRQDLEGIVFNSAI-VIAF----------- 271
                        .|....|.....:.|.||     |....||.:.|..: ||::
Zfish   342 GGPHFVTNCQTDGNRTQRIRGRMRYFSNITLGGRDYSFSNEGYLANPFLDVISYTPGSGWEDVGW 406

  Fly   272 ----------------------PDLFTNIEDLSLRH--------IDTISKVNHR----------- 295
                                  ||...::..::|..        .|..|....|
Zfish   407 WENGVLRLRYPAWSRYGPFLQPPDDAQHLRVVTLEERPFVIVELADAASGTCIRDSVPCRRPLNA 471

  Fly   296 --------------------LMLELANRLNMSYNTYQTVN--YGWRQPNGSFDGLMGRFQRYELD 338
                                ::..||..:..:|:.|...|  :| ::.:|.::|::|.......|
Zfish   472 SALQEGVAPVKQCCKGFCIDILKRLARIVGFTYDLYLVTNGKHG-KKIDGVWNGMVGEVVYKRAD 535

  Fly   339 LAQLAIFMRLDRIALVDFVAETYRVRAGIMFRQPPLSAVANIFAMPFENDVWVS--ILMLLIITT 401
            :|..::.:..:|..:|||..........:|..:...:...:.|..|:...|||.  ::.|.::..
Zfish   536 MAIGSLTINEERSEVVDFSVPFVETGISVMVSRSNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAV 600

  Fly   402 VVLVLELFFSPHNHDMSYMD-------------TLNFVWGAMCQQGFYVE-VRNRSARIIVFT-T 451
            .|.:.| ||||..::.|...             ::..:|..:......|| .:..:::|:|.. .
Zfish   601 TVFIFE-FFSPVGYNRSLQSGKKAGGSKFTIGKSIWLLWALVFNNSVPVENPKGTTSKIMVLVWA 664

  Fly   452 FVAALFLFTSFSANIVALL--QSPSDAIQSLSDLG-QSPLEIGVQDTQYNKIYF-TESTDPVTKN 512
            |.|.:|| .|::||:.|.:  :...|.:..|||.. |.|.|      ||..:.| |.......||
Zfish   665 FFAVIFL-ASYTANLAAFMIQEEYIDTVSGLSDKKFQHPTE------QYPPLKFGTVPNGSTEKN 722

  Fly   513 L-------------YHKKIASKGENIYMRPLLGMEKMRTG---LFAYQVELQAGYQIVSDTFSEP 561
            :             |::|....          .:..::||   .|.|...: ..|....|
Zfish   723 IRSNYPDMHQYMVKYNQKSVED----------AISHLKTGKLDAFIYDAAV-LNYMARKD----- 771

  Fly   562 EKCGLMELEPFQLPMLAIPTRKNFP---YKELIRRQLRWQREVSL----------VNREERKWI 612
            |.|.:|          .|.:.|.|.   |...:.:..||:|.:.|          :...||.|:
Zfish   772 EGCKVM----------TIGSGKVFATTGYGIALIKNSRWKRPLDLALLQLVGDDEIEMLERLWL 825

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75d	NP_649074.2	Periplasmic_Binding_Protein_Type_2	299..>483	CDD:304360	45/204 (22%)
Ir75d	NP_649074.2	Lig_chan	388..644	CDD:278489	59/275 (21%)
LOC100149482	XP_009290417.1	PBP1_iGluR_NMDA_NR2	44..421	CDD:107373	50/273 (18%)
		PBP2_iGluR_NMDA_Nr2	433..831	CDD:270436	81/428 (19%)
		HisJ	<487..>570	CDD:223904	16/83 (19%)
		Lig_chan	585..857	CDD:278489	59/275 (21%)
		NMDAR2_C	868..>900	CDD:287527
		FAM76	<1763..>1856	CDD:292665
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591534
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.830