DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6841 and PRP6

DIOPT Version :9

Sequence 1:	NP_001303371.1	Gene:	CG6841 / 40064	FlyBaseID:	FBgn0036828	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_009611.1	Gene:	PRP6 / 852344	SGDID:	S000000259	Length:	899	Species:	Saccharomyces cerevisiae

Alignment Length:	978	Identity:	272/978 - (27%)
Similarity:	437/978 - (44%)	Gaps:	153/978 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 FLGVPAPLGYVAGVGRGATGFTTRSDIGPARDANDVSDDRHAPPATKRKKKDEEEEEDEDLNDSN 81
            ||....|.|||.|:|||||||:|       ::...||:|.......||.:        |:||:.
Yeast     6 FLDQEPPAGYVPGIGRGATGFST-------KEKQVVSNDDKGRRIPKRYR--------ENLNNH- 54

  Fly    82 YDEFSGYSGSLFSKDPYDKDDEEADAIYDSIDKRMDEKRKEYRDRRLREDLERYRQERPKIQQQF 146
                       ....|.|.:|:||..::.:::.::.:|:|    :|..|..:....:...:::||
Yeast    55 -----------LQSQPKDDEDDEAANVFKTLELKLAQKKK----KRANEKDDDNSVDSSNVKRQF 104

  Fly   147 SDLKRSLASVTSEEWSTIPEVGDSRNRKQRNPRAE----KFTPLPDSLISRNLGGESSSTLDPSS 207
            :|||.|||:||..||..||:..|...|.:||...|    |....|||||
Yeast   105 ADLKESLAAVTESEWMDIPDATDFTRRNKRNRIQEQLNRKTYAAPDSLI---------------- 153

  Fly   208 GLASMVPGVATPGMLTPTGDLDLRKIGQARNTLMNVKLSQVSDSVTGQT--------------VV 258
                             .|::||.|:.:.|..|:.   ||:.:::...|              ..
Yeast   154 -----------------PGNVDLNKLTEEREKLLQ---SQIDENLAQLTKNASNPIQVNKPNAAT 198

  Fly   259 DPKGYLTDLQS--MIPTYGGDINDIKKARLLLKSVRETNPNHPPAWIASARLEEVTGKVQMARNL 321
            |...||.||::  :.......:.|::|.|.:|||.|:.:|.:|..|||||||||...|..:|:.:
Yeast   199 DALSYLKDLENDRVNSLSDATLEDLQKMRTILKSYRKADPTNPQGWIASARLEEKARKFSVAKKI 263

  Fly   322 IMRGCEMNIQSEDLWLEAARLQPPDT--AKAVIAQAARHIPTSVRIWIKAADLESETKAKRRVFR 384
            |..||:...:|.|:|||..||...|.  .|.::|.|....|||..:|.||.||||.|..|.||.|
Yeast   264 IENGCQECPRSSDIWLENIRLHESDVHYCKTLVATAINFNPTSPLLWFKAIDLESTTVNKYRVVR 328

  Fly   385 KALEHIPNSVRLWKAAVELENPDDARI--LLSRAVECCNTSVELWLALARLETYENARKVLNKAR 447
            |||:.||....|||.||..| .|.|::  :|.:|.:....|::|..|...|::|.||:..||..|
Yeast   329 KALQEIPRDEGLWKLAVSFE-ADKAQVIKMLEKATQFIPQSMDLLTAYTNLQSYHNAKMTLNSFR 392

  Fly   448 ENIPTDRQIWTTAAKLEEANGNIHMVEKIID---RSLTSLTVNGVEINRDQWFQEAIEAEKSGAV 509
            :.:|.:.:||..:..|||.|.....|:|::.   ..|..|:.||.:.....|.:.|.....:...
Yeast   393 KILPQEPEIWIISTLLEERNNPDIPVDKLVSLLKEGLLELSKNGYKATLSAWLKRAEALNDAPNS 457

  Fly   510 N-CCQSIVKAVIGIGVEEEDRKQTWI-DDAEFCAKENAFECARAVYAHA-LQIFPSKKSI----- 566
            | .||:||.|::           .|: :..|:.::.|..:.......|: :||...||.|
Yeast   458 NLTCQAIVYAIL-----------EWLRESGEYESELNNVDQILEKMPHSKVQIAVLKKLIQWDPC 511

  Fly   567 ----WLRAAYFEKNHGTRESLEALLQRAVAHC-----------PKSEILWLMGAKSKWMA--GDV 614
                |.|.....:::...|.|.|..|..:...           .||..|.:|.....|.|  ||.
Yeast   512 DTVLWSRLKMATESYHKIEELLAFFQELLFQTKNSDDIRANMREKSPGLLMMYVSEYWKAQKGDT 576

  Fly   615 PAARGILSLAFQANPNSEDIWLAAVKLESENSEYERARRLLAKARGS------APTPRVMMKSAR 673
            .....::.......|::.|:....:||...:.:.:..|....:...|      :.|.|:..|...
Yeast   577 RQTLVLIDQIIDFAPHNLDLRFFKIKLLGRSLQLDELRDFFQQTFSSLEDFKISGTERLYYKYVN 641

  Fly   674 LEWALEKFDEALRLL-EEAVEVFPDFPKLWMMKGQIEEQQRRTDDAAATYTLGLKKCPTSIPLWI 737
            .....:..:||::.| |..::.||...|.::..|||.......:.:..||..|.:..|....||:
Yeast   642 FLRYQDLNEEAIKFLNERCLKSFPICHKFFLQLGQIYHSMGNIEMSRETYLSGTRLVPNCPLLWV 706

  Fly   738 LSANLEE---RKGVLTKARSILERGRLRNPKVAVLWLEAIRVELRAGLKEIASTMMARALQECPN 799
            ..:.::|   :..|  :|||||:||.|:||...:.::..|::|:|.|..:.|..::.:|||:.|:
Yeast   707 SLSKIDEIDLKNPV--RARSILDRGLLKNPDDVLFYIAKIQMEIRLGNLDQAELLVTQALQKFPS 769

  Fly   800 AGELWAEAIFM----ETKPQRKTKSVDALKKCEHDPHVLLAVSKLFWSEHKFSKCRDWFNRTVKI 860
            ...||.|.|.:    .....:||...|||::.::|..|||.:...|::|.::.....|..|.:|.
Yeast   770 NALLWVEQIKLFKHGNKSSLKKTIFQDALRRTQNDHRVLLEIGVSFYAEAQYETSLKWLERALKK 834

  Fly   861 DPDLGDAWAYFYK-FELLHGTEAQQQEVLDRCISAEPTHGESWCRVSKNIQNWQFKTP-EVLRAV 923
            ....||.|.:.:: :..|.........:.|:|   |||:|..|...|||:: .|:.|| |:|..:
Yeast   835 CSRYGDTWVWLFRTYARLGKDTVDLYNMFDQC---EPTYGPEWIAASKNVK-MQYCTPREILLRL 895

  Fly   924 VRE 926
            :.:
Yeast   896 MND 898

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6841	NP_001303371.1	PRP1_N	22..173	CDD:283962	45/150 (30%)
		TPR repeat	393..419	CDD:276809	10/27 (37%)
		TPR repeat	424..448	CDD:276809	8/23 (35%)
		HAT	434..466	CDD:214642	11/31 (35%)
		TPR repeat	454..481	CDD:276809	8/29 (28%)
		TPR	543..803	CDD:223533	67/292 (23%)
		HAT	546..576	CDD:214642	8/39 (21%)
		TPR repeat	633..660	CDD:276809	4/26 (15%)
		TPR_14	665..708	CDD:290164	10/43 (23%)
		TPR repeat	698..728	CDD:276809	7/29 (24%)
		TPR repeat	733..758	CDD:276809	9/27 (33%)
		TPR repeat	767..795	CDD:276809	6/27 (22%)
PRP6	NP_009611.1	PRP1_N	11..131	CDD:399435	45/150 (30%)
		U3_assoc_6	201..>370	CDD:421384	69/169 (41%)
		PEP_TPR_lipo	609..>831	CDD:274350	58/223 (26%)
		TPR repeat	634..662	CDD:276809	6/27 (22%)
		TPR repeat	668..696	CDD:276809	7/27 (26%)
		TPR repeat	701..732	CDD:276809	11/32 (34%)
		U3_assoc_6	715..>825	CDD:421384	35/111 (32%)
		TPR repeat	737..765	CDD:276809	6/27 (22%)
		TPR repeat	770..800	CDD:276809	9/29 (31%)
		TPR repeat	805..833	CDD:276809	7/27 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343218
Domainoid	1	1.000	174	1.000	Domainoid score	I749
eggNOG	1	0.900	-	-		E1_KOG0495
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	326	1.000	Inparanoid score	I437
Isobase	1	0.950	-	0	Normalized mean entropy	S1115
OMA	1	1.010	-	-		QHG54558
OrthoFinder	1	1.000	-	-		FOG0004740
OrthoInspector	1	1.000	-	-		oto99951
orthoMCL	1	0.900	-	-		OOG6_102682
Panther	1	1.100	-	-	LDO	PTHR11246
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R989
SonicParanoid	1	1.000	-	-		X3335
TreeFam	1	0.960	-	-
	15	14.740