Protein Alignment Prp6 and SYF1

DIOPT Version :10

• Sequence 1: NP_649073.1
• Gene: Prp6 / 40064
• FlyBaseID: FBgn0036828
• Length: 931
• Species: Drosophila melanogaster
• Sequence 2: NP_010704.1
• Gene: SYF1 / 852025
• SGDID: S000002824
• Length: 859
• Species: Saccharomyces cerevisiae
• Alignment Length: 716
• Identity: 142/716 - (19%)
• Similarity: 243/716 - (33%)
• Gaps: 210/716 - (29%)

  Fly    60 PATKRKKKDEEEEEDEDLND-SNYDEFSGYSGSLFSKDPYDKDDEEADAIYDSIDKRMDEKRKEY 123
            |.|:.....|:|||..|..: .|.....|::...|..:...::....| |:.|
Yeast   161 PLTQLDSTQEDEEESTDEAELINVLLVKGFTKGGFISEEISENGSRGD-IWSS------------ 212

  Fly   124 RDRRLREDLERYRQERPKIQQQFSDLKRSLASVT-SEEWSTIPEVGDSRNRKQRNPRAEKFTP-- 185
                  ..||||.:..|  ||:.::   |||::. :.:..||..|.:....:..|  :.|:.|
Yeast   213 ------HILERYLKVAP--QQKRNE---SLATLALTRDNITIKSVYEKYLPQDEN--SGKYLPSS 264

  Fly   186 -LPDSLISRNLGGESSSTLD--------------PSSGL---ASMVPGVATPGMLTPTGDLDLRK 232
             ||..|....|.......||              |...|   .|:.....:.|.|...|||..:.
Yeast   265 ELPFELNFNYLASLEKLGLDNQYEEFMRQMNGIYPDKWLFLILSLAKYYISRGRLDSCGDLLKKS 329

  Fly   233 IGQAR-----NTLMNVKL---SQVSDSVTGQTVVDP-------------KGYLTDLQSMIPTYGG 276
            :.|..     :.:.|..|   .:.|..:.|:...:.             :.::...:|:|..|..
Yeast   330 LQQTLRYSDFDRIYNFYLLFEQECSQFILGKLKENDSKFFNQKDWTEKLQAHMATFESLINLYDI 394

  Fly   277 DINDI-----------------------KKARLLLKSVRETNPNHPPAWIASARLEEVTGKVQMA 318
            .:||:                       :|..:..:::.:.:|.......:..||....|.:...
Yeast   395 YLNDVALRQDSNLVETWMKRVSLQKSAAEKCNVYSEAILKIDPRKVGTPGSFGRLWCSYGDLYWR 459

  Fly   319 RNLIMRGCEMNIQS-----------EDLWLEAA--RLQPPDTAKAV-IAQAARHIPTSVRIWIKA 369
            .|.|....|:..||           |:::|..|  .|......:|. |.:.|.|:||:..|.
Yeast   460 SNAISTARELWTQSLKVPYPYIEDLEEIYLNWADRELDKEGVERAFSILEDALHVPTNPEIL--- 521

  Fly   370 ADLESETKAKRRVFRKALEHIPNSVRLWKAAVE-LEN--PDDARI---LLSRAVECCNTSVELWL 428
              ||......|::  .|...:.||:|:|...:: ||.  |.||..   :.::.....||.::|.|
Yeast   522 --LEKYKNGHRKI--PAQTVLFNSLRIWSKYIDYLEAYCPKDANSSDKIFNKTKMAYNTVIDLRL 582

  Fly   429 ---------ALARLETYE--NARKVLNKARENIPTDRQ--IW------TTAAKLEEANGNIHMVE 474
                     ||.....||  .:.:|..|.....|.:.|  :|      .|:.:|...:.. | :.
Yeast   583 ITPAMAENFALFLQNHYEVMESFQVYEKTIPLFPPEIQYELWIEYLEVATSHQLSSLSPE-H-IR 645

  Fly   475 KIIDRSLTSLTVNGVEINRDQWFQEAIEAEKSGAVNCCQSIVK--AVIG---IGVEEEDRKQTW- 533
            .:.:::|.:|..||::...........|...||.::....|::  ||||   :....|.|.|.|
Yeast   646 FLFEKALKNLCSNGIDCKTIFIAYSVFEERISGLISKSIEILRRGAVIGTVSVSTHLESRLQLWR 710

  Fly   534 --IDDA--------------------------EFCAKENAFEC-------ARAVYAHALQIFPSK 563
              |..|                          ||..|.:.||.       ||.:.|:..::.|..
Yeast   711 MCISKAESTLGPSVTRELYQECIQILPNSKAVEFVIKFSDFESSIGETIRAREILAYGAKLLPPS 775

  Fly   564 KS--IWLRAAYFEKNHGTRESLEALLQ---------------------------RAVAHCPKSEI 599
            ::  :|.....||..||.:|:.:.:|:                           .|.:|.|.|..
Yeast   776 RNTELWDSFEIFELKHGDKETYKDMLKMKKVLESNMLIDSASVSHEEGNINFVAAATSHAPNSHT 840

  Fly   600 L 600
            |
Yeast   841 L 841

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prp6	NP_649073.1	PRP1_N	22..173	CDD:461908	26/114 (23%)
		PEP_TPR_lipo	236..>800	CDD:274350	98/518 (19%)
		TPR repeat	393..419	CDD:276809	8/31 (26%)
		TPR repeat	424..448	CDD:276809	8/34 (24%)
		TPR repeat	454..481	CDD:276809	5/34 (15%)
		LapB	610..861	CDD:442196
		TPR repeat	633..660	CDD:276809
		TPR repeat	698..728	CDD:276809
		TPR repeat	733..758	CDD:276809
		TPR repeat	767..795	CDD:276809
SYF1	NP_010704.1	RNA14	16..>102	CDD:227438