DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6841 and prpf6

DIOPT Version :9

Sequence 1:	NP_001303371.1	Gene:	CG6841 / 40064	FlyBaseID:	FBgn0036828	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_997820.2	Gene:	prpf6 / 323855	ZFINID:	ZDB-GENE-030131-2575	Length:	974	Species:	Danio rerio

Alignment Length:	929	Identity:	659/929 - (70%)
Similarity:	782/929 - (84%)	Gaps:	12/929 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 NRNKKHFLGVPAPLGYVAGVGRGATGFTTRSDIGPARDANDVSDDRHAPPATKR---KKKDEEEE 72
            |:.||.|||:|||||||.|:|||||||||||||||||||||..|||||||..:.   :.|..:::
Zfish    42 NKKKKPFLGMPAPLGYVPGLGRGATGFTTRSDIGPARDANDPVDDRHAPPGKRTVGDQMKKSQDD 106

  Fly    73 EDEDLNDSNYDEFSGYSGSLFSKDPYDKDDEEADAIYDSIDKRMDEKRKEYRDRRLREDLERYRQ 137
            :||||||:|||||:||:|||||..||:||||||||||.::||||||:|||.|:.|.:|::|:||.
Zfish   107 DDEDLNDTNYDEFNGYAGSLFSSGPYEKDDEEADAIYAALDKRMDERRKERRELREKEEIEKYRM 171

  Fly   138 ERPKIQQQFSDLKRSLASVTSEEWSTIPEVGDSRNRKQRNPRAEKFTPLPDSLISRNL-GGESSS 201
            ||||||||||||||.|:.||.:||.:||||||:||::|||||.||.||:|||..:::| .||:.:
Zfish   172 ERPKIQQQFSDLKRKLSEVTEDEWLSIPEVGDARNKRQRNPRYEKLTPVPDSFFAKHLQTGENHT 236

  Fly   202 TLDP----SSGLASMVPG---VATPGMLTP-TGDLDLRKIGQARNTLMNVKLSQVSDSVTGQTVV 258
            ::||    ..||.:..||   ...||.:|| .|:||:|||||||||||:::||||||||:|||||
Zfish   237 SVDPLQGQFGGLNTPFPGGLNTPYPGGMTPDAGELDMRKIGQARNTLMDMRLSQVSDSVSGQTVV 301

  Fly   259 DPKGYLTDLQSMIPTYGGDINDIKKARLLLKSVRETNPNHPPAWIASARLEEVTGKVQMARNLIM 323
            |||||||||.||||||||||:|||||||||||||||||:|||||||||||||||||:|:||||||
Zfish   302 DPKGYLTDLNSMIPTYGGDISDIKKARLLLKSVRETNPHHPPAWIASARLEEVTGKLQVARNLIM 366

  Fly   324 RGCEMNIQSEDLWLEAARLQPPDTAKAVIAQAARHIPTSVRIWIKAADLESETKAKRRVFRKALE 388
            :|.||..:|||:|||||||||.||||||:|||.||:|.||||:|:||:||::.:||:||.|||||
Zfish   367 KGTEMCPKSEDVWLEAARLQPGDTAKAVVAQAVRHLPQSVRIYIRAAELETDIRAKKRVLRKALE 431

  Fly   389 HIPNSVRLWKAAVELENPDDARILLSRAVECCNTSVELWLALARLETYENARKVLNKARENIPTD 453
            ::..||||||.|||||.|:||||:||||||||.|||||||||||||||||||:||||||||||||
Zfish   432 NVSKSVRLWKTAVELEEPEDARIMLSRAVECCPTSVELWLALARLETYENARRVLNKARENIPTD 496

  Fly   454 RQIWTTAAKLEEANGNIHMVEKIIDRSLTSLTVNGVEINRDQWFQEAIEAEKSGAVNCCQSIVKA 518
            |.||.|||||||||||..||||||||::|||..|||||||:||.|:|.|.:|:|:|..|||:::|
Zfish   497 RHIWITAAKLEEANGNTQMVEKIIDRAITSLRANGVEINREQWIQDAEECDKAGSVVTCQSVIRA 561

  Fly   519 VIGIGVEEEDRKQTWIDDAEFCAKENAFECARAVYAHALQIFPSKKSIWLRAAYFEKNHGTRESL 583
            |||||:||||.|.||::||:.|....|.|||||:||||||:||||||:||||||||||:||||||
Zfish   562 VIGIGIEEEDCKHTWMEDADSCVSHGALECARAIYAHALQVFPSKKSVWLRAAYFEKNNGTRESL 626

  Fly   584 EALLQRAVAHCPKSEILWLMGAKSKWMAGDVPAARGILSLAFQANPNSEDIWLAAVKLESENSEY 648
            |||||||||||||:|:||||||||||:||||||||.||:||||||||||:||||||||||||:||
Zfish   627 EALLQRAVAHCPKAEVLWLMGAKSKWLAGDVPAARSILALAFQANPNSEEIWLAAVKLESENNEY 691

  Fly   649 ERARRLLAKARGSAPTPRVMMKSARLEWALEKFDEALRLLEEAVEVFPDFPKLWMMKGQIEEQQR 713
            |||||||||||.||||.||.|||.||||.|...:.|..|..||::.:.||||||||:||||||..
Zfish   692 ERARRLLAKARSSAPTARVFMKSVRLEWVLGNIEAAHELCTEALKHYEDFPKLWMMRGQIEEQSE 756

  Fly   714 RTDDAAATYTLGLKKCPTSIPLWILSANLEERKGVLTKARSILERGRLRNPKVAVLWLEAIRVEL 778
            ..|.|...|..||||||.|:.||:|.:.|||:.|.||:||:|||:.||:||:...||||::|:|.
Zfish   757 SIDRAREAYNQGLKKCPHSMSLWLLLSRLEEKVGQLTRARAILEKARLKNPQSPELWLESVRLEY 821

  Fly   779 RAGLKEIASTMMARALQECPNAGELWAEAIFMETKPQRKTKSVDALKKCEHDPHVLLAVSKLFWS 843
            |||||.||:|:||:|||||||:|.||:||:|:|.:||||||||||||||||||||||||:|||||
Zfish   822 RAGLKNIANTLMAKALQECPNSGILWSEAVFLEARPQRKTKSVDALKKCEHDPHVLLAVAKLFWS 886

  Fly   844 EHKFSKCRDWFNRTVKIDPDLGDAWAYFYKFELLHGTEAQQQEVLDRCISAEPTHGESWCRVSKN 908
            |.|.:|.|:||.|||||:|||||||.:||||||.||||.||.||..||.:|||.|||.||..||:
Zfish   887 ERKITKAREWFLRTVKIEPDLGDAWGFFYKFELQHGTEEQQHEVKKRCENAEPRHGELWCAESKH 951

  Fly   909 IQNWQFKTPEVLRAVVREL 927
            |.|||....|:|..|..::
Zfish   952 ILNWQKNIGEILVLVASKI 970

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6841	NP_001303371.1	PRP1_N	22..173	CDD:283962	107/153 (70%)
		TPR repeat	393..419	CDD:276809	21/25 (84%)
		TPR repeat	424..448	CDD:276809	22/23 (96%)
		HAT	434..466	CDD:214642	28/31 (90%)
		TPR repeat	454..481	CDD:276809	22/26 (85%)
		TPR	543..803	CDD:223533	187/259 (72%)
		HAT	546..576	CDD:214642	25/29 (86%)
		TPR repeat	633..660	CDD:276809	24/26 (92%)
		TPR_14	665..708	CDD:290164	23/42 (55%)
		TPR repeat	698..728	CDD:276809	18/29 (62%)
		TPR repeat	733..758	CDD:276809	13/24 (54%)
		TPR repeat	767..795	CDD:276809	17/27 (63%)
prpf6	NP_997820.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592546
Domainoid	1	1.000	662	1.000	Domainoid score	I146
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5368
Inparanoid	1	1.050	1346	1.000	Inparanoid score	I132
OMA	1	1.010	-	-		QHG54558
OrthoDB	1	1.010	-	-		D107151at33208
OrthoFinder	1	1.000	-	-		FOG0004740
OrthoInspector	1	1.000	-	-		oto40618
orthoMCL	1	0.900	-	-		OOG6_102682
Panther	1	1.100	-	-	LDO	PTHR11246
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R989
SonicParanoid	1	1.000	-	-		X3335
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	15	14.940