Protein Alignment Prp6 and PRPF6

DIOPT Version :10

• Sequence 1: NP_649073.1
• Gene: Prp6 / 40064
• FlyBaseID: FBgn0036828
• Length: 931
• Species: Drosophila melanogaster
• Sequence 2: NP_036601.2
• Gene: PRPF6 / 24148
• HGNCID: 15860
• Length: 941
• Species: Homo sapiens
• Alignment Length: 932
• Identity: 673/932 - (72%)
• Similarity: 792/932 - (84%)
• Gaps: 19/932 - (2%)

  Fly    11 NRNKKHFLGVPAPLGYVAGVGRGATGFTTRSDIGPARDANDVSDDRHAPPATK-----RKKKDEE 70
            |:.||.|||:|||||||.|:|||||||||||||||||||||..|||||||..:     .||....
Human     2 NKKKKPFLGMPAPLGYVPGLGRGATGFTTRSDIGPARDANDPVDDRHAPPGKRTVGDQMKKNQAA 66

  Fly    71 EEEDEDLNDSNYDEFSGYSGSLFSKDPYDKDDEEADAIYDSIDKRMDEKRKEYRDRRLREDLERY 135
            :::||||||:|||||:||:|||||..||:||||||||||.::||||||:|||.|::|.:|::|:|
Human    67 DDDDEDLNDTNYDEFNGYAGSLFSSGPYEKDDEEADAIYAALDKRMDERRKERREQREKEEIEKY 131

  Fly   136 RQERPKIQQQFSDLKRSLASVTSEEWSTIPEVGDSRNRKQRNPRAEKFTPLPDSLISRNL-GGES 199
            |.||||||||||||||.||.||.|||.:||||||:||::|||||.||.||:|||..:::| .||:
Human   132 RMERPKIQQQFSDLKRKLAEVTEEEWLSIPEVGDARNKRQRNPRYEKLTPVPDSFFAKHLQTGEN 196

  Fly   200 SSTLDP------------SSGLASMVPGVATPGMLTP-TGDLDLRKIGQARNTLMNVKLSQVSDS 251
            .:::||            ..||.:..||..|||::|| ||:||:|||||||||||:::|||||||
Human   197 HTSVDPRQTQFGGLNTPYPGGLNTPYPGGMTPGLMTPGTGELDMRKIGQARNTLMDMRLSQVSDS 261

  Fly   252 VTGQTVVDPKGYLTDLQSMIPTYGGDINDIKKARLLLKSVRETNPNHPPAWIASARLEEVTGKVQ 316
            |:||||||||||||||.|||||:||||||||||||||||||||||:|||||||||||||||||:|
Human   262 VSGQTVVDPKGYLTDLNSMIPTHGGDINDIKKARLLLKSVRETNPHHPPAWIASARLEEVTGKLQ 326

  Fly   317 MARNLIMRGCEMNIQSEDLWLEAARLQPPDTAKAVIAQAARHIPTSVRIWIKAADLESETKAKRR 381
            :||||||:|.||..:|||:|||||||||.||||||:|||.||:|.||||:|:||:||::.:||:|
Human   327 VARNLIMKGTEMCPKSEDVWLEAARLQPGDTAKAVVAQAVRHLPQSVRIYIRAAELETDIRAKKR 391

  Fly   382 VFRKALEHIPNSVRLWKAAVELENPDDARILLSRAVECCNTSVELWLALARLETYENARKVLNKA 446
            |.||||||:||||||||||||||.|:||||:||||||||.|||||||||||||||||||||||||
Human   392 VLRKALEHVPNSVRLWKAAVELEEPEDARIMLSRAVECCPTSVELWLALARLETYENARKVLNKA 456

  Fly   447 RENIPTDRQIWTTAAKLEEANGNIHMVEKIIDRSLTSLTVNGVEINRDQWFQEAIEAEKSGAVNC 511
            ||||||||.||.|||||||||||..||||||||::|||..|||||||:||.|:|.|.:::|:|..
Human   457 RENIPTDRHIWITAAKLEEANGNTQMVEKIIDRAITSLRANGVEINREQWIQDAEECDRAGSVAT 521

  Fly   512 CQSIVKAVIGIGVEEEDRKQTWIDDAEFCAKENAFECARAVYAHALQIFPSKKSIWLRAAYFEKN 576
            ||::::||||||:||||||.||::||:.|...||.|||||:||:|||:||||||:||||||||||
Human   522 CQAVMRAVIGIGIEEEDRKHTWMEDADSCVAHNALECARAIYAYALQVFPSKKSVWLRAAYFEKN 586

  Fly   577 HGTRESLEALLQRAVAHCPKSEILWLMGAKSKWMAGDVPAARGILSLAFQANPNSEDIWLAAVKL 641
            ||||||||||||||||||||:|:||||||||||:||||||||.||:||||||||||:||||||||
Human   587 HGTRESLEALLQRAVAHCPKAEVLWLMGAKSKWLAGDVPAARSILALAFQANPNSEEIWLAAVKL 651

  Fly   642 ESENSEYERARRLLAKARGSAPTPRVMMKSARLEWALEKFDEALRLLEEAVEVFPDFPKLWMMKG 706
            ||||.|||||||||||||.||||.||.|||.:|||..:....|..|.|||:..:.||||||||||
Human   652 ESENDEYERARRLLAKARSSAPTARVFMKSVKLEWVQDNIRAAQDLCEEALRHYEDFPKLWMMKG 716

  Fly   707 QIEEQQRRTDDAAATYTLGLKKCPTSIPLWILSANLEERKGVLTKARSILERGRLRNPKVAVLWL 771
            |||||:...:.|...|..||||||.|.|||:|.:.|||:.|.||:||:|||:.||:|||...|||
Human   717 QIEEQKEMMEKAREAYNQGLKKCPHSTPLWLLLSRLEEKIGQLTRARAILEKSRLKNPKNPGLWL 781

  Fly   772 EAIRVELRAGLKEIASTMMARALQECPNAGELWAEAIFMETKPQRKTKSVDALKKCEHDPHVLLA 836
            |::|:|.|||||.||:|:||:|||||||:|.||:||||:|.:|||:|||||||||||||||||||
Human   782 ESVRLEYRAGLKNIANTLMAKALQECPNSGILWSEAIFLEARPQRRTKSVDALKKCEHDPHVLLA 846

  Fly   837 VSKLFWSEHKFSKCRDWFNRTVKIDPDLGDAWAYFYKFELLHGTEAQQQEVLDRCISAEPTHGES 901
            |:|||||:.|.:|.|:||:||||||.|||||||:||||||.||||.||:||..||.||||.|||.
Human   847 VAKLFWSQRKITKAREWFHRTVKIDSDLGDAWAFFYKFELQHGTEEQQEEVRKRCESAEPRHGEL 911

  Fly   902 WCRVSKNIQNWQFKTPEVLRAV 923
            ||.|||:|.|||.|..::||.|
Human   912 WCAVSKDIANWQKKIGDILRLV 933

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prp6	NP_649073.1	PRP1_N	22..173	CDD:461908	110/155 (71%)
		PEP_TPR_lipo	236..>800	CDD:274350	429/563 (76%)
		TPR repeat	393..419	CDD:276809	22/25 (88%)
		TPR repeat	424..448	CDD:276809	23/23 (100%)
		TPR repeat	454..481	CDD:276809	22/26 (85%)
		LapB	610..861	CDD:442196	174/250 (70%)
		TPR repeat	633..660	CDD:276809	24/26 (92%)
		TPR repeat	698..728	CDD:276809	18/29 (62%)
		TPR repeat	733..758	CDD:276809	14/24 (58%)
		TPR repeat	767..795	CDD:276809	17/27 (63%)
PRPF6	NP_036601.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..79		51/76 (67%)
		PRP1_N	13..169	CDD:461908	110/155 (71%)
		LapB	<289..456	CDD:442196	138/166 (83%)
		HAT 1	384..416		24/31 (77%)
		ACL4-like	393..>524	CDD:474029	105/130 (81%)
		TPR repeat	405..428	CDD:276809	19/22 (86%)
		HAT 2	418..444		23/25 (92%)
		TPR repeat	433..459	CDD:276809	25/25 (100%)
		HAT 3	445..476		28/30 (93%)
		TPR repeat	464..491	CDD:276809	22/26 (85%)
		HAT 4	554..586		26/31 (84%)
		LapB	559..806	CDD:442196	179/246 (73%)
		HAT 5	588..620		29/31 (94%)
		HAT 6	622..654		28/31 (90%)
		TPR repeat	643..670	CDD:276809	24/26 (92%)
		HAT 7	689..721		18/31 (58%)
		TPR repeat	708..738	CDD:276809	18/29 (62%)
		LapB	712..>911	CDD:442196	138/198 (70%)
		HAT 8	723..755		15/31 (48%)
		TPR repeat	743..768	CDD:276809	14/24 (58%)
		TPR repeat	777..805	CDD:276809	17/27 (63%)
		HAT 9	855..887		23/31 (74%)