DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CSN1b and gps1

DIOPT Version :9

Sequence 1:	NP_524152.2	Gene:	CSN1b / 40063	FlyBaseID:	FBgn0027057	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	XP_021327265.1	Gene:	gps1 / 777711	ZFINID:	ZDB-GENE-041111-240	Length:	527	Species:	Danio rerio

Alignment Length:	514	Identity:	312/514 - (60%)
Similarity:	391/514 - (76%)	Gaps:	49/514 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 MQNAVEPMQVDIAPPNEDNENNEEQQIVVENPSIDLEVYANQYAGIVRLHRLIYVADVCPVLAVE 74
            ::.:|||||:| |.|.||.:|..:...|||||::|||.||:.|:|::|:.||.::||.||.|.||
Zfish    50 LEGSVEPMQID-ADPQEDQQNAPDTNYVVENPTLDLEQYASSYSGLMRIERLQFIADHCPQLRVE 113

  Fly    75 ALKMAITYVQTTYNVNLYQVLHKRLSDLNAGNAPAPPANAGGDQAGAAAPGPLAAAPLPDIAAQP 139
            |||||:::||.|:||::|:.:|::|::........|.|    ...||..|.||
Zfish   114 ALKMALSFVQRTFNVDVYEEIHRKLTEATREVQGVPDA----VPEGAVEPPPL------------ 162

  Fly   140 VAQAQGQAQPAVEKDAFAYDAAWVDTKMKKAALKLEKLDSDLKNYKSNSIKESIRRGHDDLADHY 204
                               |.||.::..|||.|||||||:||||||.||||||||||||||.|||
Zfish   163 -------------------DTAWAESTRKKALLKLEKLDTDLKNYKGNSIKESIRRGHDDLGDHY 208

  Fly   205 LSCGDLTNALKCYSRARDYCTSGKHVVNMCLNVIKVSIYLQNWAHVMSYISKAESTPDFAEGSKE 269
            |.||||:|||||||||||||||.|||:||||||||||:|||||:||:||:|||||||:.||...|
Zfish   209 LDCGDLSNALKCYSRARDYCTSAKHVINMCLNVIKVSVYLQNWSHVLSYVSKAESTPEIAEQRGE 273

  Fly   270 ANAQ---VHTRLECAAGLAELQQKKYKVAAKHFLNANFDHCDFPEMISTSNVAVYGGLCALATFD 331
            .::|   |.|:|:||||||||..:|||.|||.||.|:||||||||::|.||||||||||||||||
Zfish   274 RDSQNQAVLTKLKCAAGLAELASRKYKPAAKCFLQASFDHCDFPELLSPSNVAVYGGLCALATFD 338

  Fly   332 RQELKRLVIASTSFKLFLELEPQLRDIIFKFYESKYASCLTLLDEIRDNLLVDMYIAPHVTTLYT 396
            ||||:|.||:|:|||||||||||:||||||||||||||||.:|||::||||:|||:||||.||||
Zfish   339 RQELQRNVISSSSFKLFLELEPQVRDIIFKFYESKYASCLKMLDEMKDNLLLDMYLAPHVRTLYT 403

  Fly   397 KIRNRALIQYFSPYMSADMHKMAMAFNSSVGDLENEVMQLILDGQIQARIDSHNKILFAKEADQR 461
            :|||||||||||||:||||:|||:|||::|..||:|:.||||:|.|.||||||:|||:|::.|||
Zfish   404 QIRNRALIQYFSPYVSADMNKMAVAFNTTVAALEDELTQLILEGLINARIDSHSKILYARDVDQR 468

  Fly   462 NSTFERALIMGKQYQRHTRMLVLRAAMLKSHIHVKSISREGGSNHGAELCVSAGSSTTA 520
            ::|||::|.|||::||..:.::||||:|::.|||||..|||          |.|..|.|
Zfish   469 STTFEKSLQMGKEFQRRAKAMILRAAVLRNQIHVKSPPREG----------SQGELTPA 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CSN1b	NP_524152.2	RPN7	159..338	CDD:287560	138/181 (76%)
CSN1b	NP_524152.2	PCI	353..457	CDD:279707	79/103 (77%)
gps1	XP_021327265.1	RPN7	163..345	CDD:313757	138/181 (76%)
gps1	XP_021327265.1	PCI	360..464	CDD:307522	79/103 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596095
Domainoid	1	1.000	290	1.000	Domainoid score	I1504
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3046
Inparanoid	1	1.050	603	1.000	Inparanoid score	I907
OMA	1	1.010	-	-		QHG55412
OrthoDB	1	1.010	-	-		D223526at33208
OrthoFinder	1	1.000	-	-		FOG0005242
OrthoInspector	1	1.000	-	-		oto39789
orthoMCL	1	0.900	-	-		OOG6_103258
Panther	1	1.100	-	-	LDO	PTHR14145
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R254
SonicParanoid	1	1.000	-	-		X5623
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.940