DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CSN1b and gps1

DIOPT Version :9

Sequence 1:	NP_524152.2	Gene:	CSN1b / 40063	FlyBaseID:	FBgn0027057	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	XP_012821921.2	Gene:	gps1 / 493337	XenbaseID:	XB-GENE-955148	Length:	560	Species:	Xenopus tropicalis

Alignment Length:	516	Identity:	313/516 - (60%)
Similarity:	393/516 - (76%)	Gaps:	55/516 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 QNAVEPMQVDIAPPNEDNENNEEQQIVVENPSIDLEVYANQYAGIVRLHRLIYVADVCPVLAVEA 75
            ::||||||:| |.|.:|.:|..:...|||||::|||.||:.|:|::|:.||.::||.||.|.|||
Frog    84 ESAVEPMQID-ADPQDDQQNVPDVSYVVENPTLDLEQYASSYSGLMRIERLQFIADRCPQLRVEA 147

  Fly    76 LKMAITYVQTTYNVNLYQVLHKRLSDLN--AGNAP-APPANAGGDQAGAAAPGPLAAAPLPDIAA 137
            ||||:::||.|:||::|:.:|::|::.:  ..||| |.|       .|:..|.||
Frog   148 LKMALSFVQRTFNVDVYEDIHRKLTEASREVQNAPDAVP-------EGSMEPPPL---------- 195

  Fly   138 QPVAQAQGQAQPAVEKDAFAYDAAWVDTKMKKAALKLEKLDSDLKNYKSNSIKESIRRGHDDLAD 202
                                 |..||:...|||.|||||||:||||||.||||||||||||||.|
Frog   196 ---------------------DTTWVEATRKKALLKLEKLDTDLKNYKGNSIKESIRRGHDDLGD 239

  Fly   203 HYLSCGDLTNALKCYSRARDYCTSGKHVVNMCLNVIKVSIYLQNWAHVMSYISKAESTPDFAE-- 265
            |||.||||:|||||||||||||||.|||:||||||||||:|||||:||:||:|||||||:.||
Frog   240 HYLDCGDLSNALKCYSRARDYCTSAKHVINMCLNVIKVSVYLQNWSHVLSYVSKAESTPEIAEQR 304

  Fly   266 GSKEANAQ-VHTRLECAAGLAELQQKKYKVAAKHFLNANFDHCDFPEMISTSNVAVYGGLCALAT 329
            |.:::..| |.|:|:||||||||..:|||.|||.||.|:||||||||::|.||||||||||||||
Frog   305 GERDSQTQSVLTKLKCAAGLAELAARKYKQAAKCFLLASFDHCDFPELLSPSNVAVYGGLCALAT 369

  Fly   330 FDRQELKRLVIASTSFKLFLELEPQLRDIIFKFYESKYASCLTLLDEIRDNLLVDMYIAPHVTTL 394
            ||||||:|.||:|:|||||||||||:||||||||||||||||.:|||::||||:|||:||||.||
Frog   370 FDRQELQRNVISSSSFKLFLELEPQVRDIIFKFYESKYASCLKMLDEMKDNLLLDMYLAPHVRTL 434

  Fly   395 YTKIRNRALIQYFSPYMSADMHKMAMAFNSSVGDLENEVMQLILDGQIQARIDSHNKILFAKEAD 459
            ||:|||||||||||||:||||.|||.|||::|..||:|:.||||:|.|.||||||:|||:|::.|
Frog   435 YTQIRNRALIQYFSPYVSADMFKMATAFNTTVSALEDELTQLILEGLINARIDSHSKILYARDVD 499

  Fly   460 QRNSTFERALIMGKQYQRHTRMLVLRAAMLKSHIHVKSISREGGSNHGAELCVSAGSSTTA 520
            ||::|||::|.||:::||..:.::||||:|::.|||||..|||          |.|..|.|
Frog   500 QRSTTFEKSLQMGREFQRRAKAMILRAAVLRNQIHVKSPPREG----------SQGELTPA 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CSN1b	NP_524152.2	RPN7	159..338	CDD:287560	138/181 (76%)
CSN1b	NP_524152.2	PCI	353..457	CDD:279707	79/103 (77%)
gps1	XP_012821921.2	RPN7	196..378	CDD:402301	138/181 (76%)
gps1	XP_012821921.2	PCI	393..497	CDD:396121	79/103 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	289	1.000	Domainoid score	I1545
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H3046
Inparanoid	1	1.050	607	1.000	Inparanoid score	I915
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D223526at33208
OrthoFinder	1	1.000	-	-		FOG0005242
OrthoInspector	1	1.000	-	-		oto104447
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R254
SonicParanoid	1	1.000	-	-		X5623
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.090