DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CSN1b and csn1

DIOPT Version :9

Sequence 1:	NP_524152.2	Gene:	CSN1b / 40063	FlyBaseID:	FBgn0027057	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_596680.1	Gene:	csn1 / 2540352	PomBaseID:	SPBC215.03c	Length:	422	Species:	Schizosaccharomyces pombe

Alignment Length:	485	Identity:	120/485 - (24%)
Similarity:	221/485 - (45%)	Gaps:	84/485 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 DLEVYANQYAGIVRLHRLIYVA-------DVCPVLAVEALKMAITYVQTTYNVNLYQVLHKRLSD 101
            :|:.|.::|....::.|.::||       ..|...|::.||      :.|||:.|||.|.:...|
pombe    11 ELKRYLDEYGVWSKIFRALFVARNSKPLRSFCVHYAIKELK------EKTYNLELYQSLFEEFQD 69

  Fly   102 LNAGNAPAPPANAGGDQAGAAAPGPLAAAPLPDIAAQPVAQAQGQAQPAVEKDAFAYDAAWVDTK 166
                                                            ..|.:..  |..||::.
pombe    70 ------------------------------------------------CFENEQL--DVEWVESV 84

  Fly   167 MKKAALKLEKLDSDLKNYKSNSIKESIRRGHDDLADHYLSCGDLTNALKCYSRARDYCTSGKHVV 231
            .......||:|..:||.||:|.|:||||....|||..:...|...:||:.|::.|:|||:...:.
pombe    85 TFHRKQNLEQLRRELKAYKNNLIRESIRAAQLDLASFFADVGQFDSALRSYAKVREYCTNAGQIA 149

  Fly   232 NMCLNVIKVSIYLQNWAHVMSYISKAESTPDFAEGSKEANAQVHTRLECAAGLAELQQKKYKVAA 296
            ::.|.::::||::.|::||:::.|:|:||   ...:.|..:.::    ...|||......|:.|.
pombe   150 HLSLELMRISIWIGNYSHVLAFGSRAKST---VSAAMELTSPIY----AYCGLANFCLGDYEEAL 207

  Fly   297 KHFLNANFDHCDFPEMISTSNVAVYGGLCALATFDRQELKRLVIASTSFKLFLELEPQLRDIIFK 361
            .|||....|..|  .:|:.::::||..|||||.:|.:.|.:.:..:..|....:|:|.||..:..
pombe   208 AHFLKVETDTSD--GIITKTDISVYISLCALACWDHKRLIQELERNEEFNALSDLDPSLRRCLQA 270

  Fly   362 FYESKYASCLTLLDEIRDNLLVDMYIAPHVTTLYTKIRNRALIQYFSPYMSADMHKMAMAFNSSV 426
            ....||:..|..|.:...:..:|||:||.:|.|::.||.|:|:.|..||.:....|:|:.|:...
pombe   271 KCNRKYSLLLDTLQQNAQDYSLDMYLAPQLTNLFSLIRERSLLDYLIPYSALPFSKIAVDFHIDE 335

  Fly   427 GDLENEVMQLILDGQIQARIDSHNKILFAKEADQRNSTFERALIMGKQYQRHTRMLVLRAAMLKS 491
            ..:|..::::|...::..::||..|.::. |.......||....:.:     |.:|..:|
pombe   336 NFIEKNLLEIIEAKKLNGKVDSLQKRVYI-EPSSEPENFEDIKNIAQ-----TSLLYSKA----- 389

  Fly   492 HIHVKSISREGGSNHGAELCVSAGSSTTAQ 521
             :::::::.....|...|..|.|.::.||:
pombe   390 -LYLQTLAAMNTENTDDEAPVIAQTNITAE 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CSN1b	NP_524152.2	RPN7	159..338	CDD:287560	58/178 (33%)
CSN1b	NP_524152.2	PCI	353..457	CDD:279707	29/103 (28%)
csn1	NP_596680.1	RPN7	77..246	CDD:287560	58/177 (33%)
csn1	NP_596680.1	PCI	262..365	CDD:279707	29/103 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	105	1.000	Domainoid score	I1702
eggNOG	1	0.900	-	-		E1_KOG0686
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	160	1.000	Inparanoid score	I1244
OMA	1	1.010	-	-		QHG55412
OrthoFinder	1	1.000	-	-		FOG0005242
OrthoInspector	1	1.000	-	-		oto101609
orthoMCL	1	0.900	-	-		OOG6_103258
Panther	1	1.100	-	-	LDO	PTHR14145
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R254
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.860