DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CSN1b and Gps1

DIOPT Version :9

Sequence 1:	NP_524152.2	Gene:	CSN1b / 40063	FlyBaseID:	FBgn0027057	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	XP_006532807.1	Gene:	Gps1 / 209318	MGIID:	2384801	Length:	529	Species:	Mus musculus

Alignment Length:	506	Identity:	312/506 - (61%)
Similarity:	393/506 - (77%)	Gaps:	42/506 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LMQNAVEPMQVDIAPPNEDNENNEEQQIVVENPSIDLEVYANQYAGIVRLHRLIYVADVCPVLAV 73
            |.:.||||||:|: .|.||.:|..:...|||||::|||.||..|:|::|:.||.::||.||.|.|
Mouse    48 LSEGAVEPMQIDV-DPQEDPQNAPDVNYVVENPTLDLEQYAASYSGLMRIERLQFIADRCPPLRV 111

  Fly    74 EALKMAITYVQTTYNVNLYQVLHKRLSDLNAGNAPAPPANAGGDQAGAAAPGPLAAAPLPDIAAQ 138
            ||||||:::||.|:||::|:.:|::||:.......||.|                   :|:...:
Mouse   112 EALKMALSFVQRTFNVDMYEEIHRKLSEATRELQNAPDA-------------------IPESGVE 157

  Fly   139 PVAQAQGQAQPAVEKDAFAYDAAWVDTKMKKAALKLEKLDSDLKNYKSNSIKESIRRGHDDLADH 203
            |         |.:       |.|||:...|||.|||||||:||||||.||||||||||||||.||
Mouse   158 P---------PPL-------DTAWVEATRKKALLKLEKLDTDLKNYKGNSIKESIRRGHDDLGDH 206

  Fly   204 YLSCGDLTNALKCYSRARDYCTSGKHVVNMCLNVIKVSIYLQNWAHVMSYISKAESTPDFAE--G 266
            ||.||||:|||||||||||||||.|||:||||||||||:|||||:||:||:|||||||:.||  |
Mouse   207 YLDCGDLSNALKCYSRARDYCTSAKHVINMCLNVIKVSVYLQNWSHVLSYVSKAESTPEIAEQRG 271

  Fly   267 SKEANAQ-VHTRLECAAGLAELQQKKYKVAAKHFLNANFDHCDFPEMISTSNVAVYGGLCALATF 330
            .:::..| :.|:|:||||||||..:|||.|||.||.|:||||||||::|.|||||||||||||||
Mouse   272 ERDSQTQAILTKLKCAAGLAELAARKYKQAAKCFLLASFDHCDFPELLSPSNVAVYGGLCALATF 336

  Fly   331 DRQELKRLVIASTSFKLFLELEPQLRDIIFKFYESKYASCLTLLDEIRDNLLVDMYIAPHVTTLY 395
            |||||:|.||:|:|||||||||||:||||||||||||||||.:|||::||||:|||:||||.|||
Mouse   337 DRQELQRNVISSSSFKLFLELEPQVRDIIFKFYESKYASCLKMLDEMKDNLLLDMYLAPHVRTLY 401

  Fly   396 TKIRNRALIQYFSPYMSADMHKMAMAFNSSVGDLENEVMQLILDGQIQARIDSHNKILFAKEADQ 460
            |:|||||||||||||:||||||||.|||::|..||:|:.||||:|.|.||||||:|||:|::.||
Mouse   402 TQIRNRALIQYFSPYVSADMHKMAAAFNTTVAALEDELTQLILEGLINARIDSHSKILYARDVDQ 466

  Fly   461 RNSTFERALIMGKQYQRHTRMLVLRAAMLKSHIH--VKSISREG-GSNHGA 508
            |::|||::|:|||::||..:.::||||:|::.||  |||:..|| |..|.|
Mouse   467 RSTTFEKSLLMGKEFQRRAKAMILRAAVLRNQIHVKVKSLGCEGMGGTHTA 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CSN1b	NP_524152.2	RPN7	159..338	CDD:287560	138/181 (76%)
CSN1b	NP_524152.2	PCI	353..457	CDD:279707	80/103 (78%)
Gps1	XP_006532807.1	RPN7	162..344	CDD:371159	138/181 (76%)
Gps1	XP_006532807.1	PCI	359..463	CDD:366616	80/103 (78%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850211
Domainoid	1	1.000	290	1.000	Domainoid score	I1544
eggNOG	1	0.900	-	-		E1_KOG0686
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3046
Inparanoid	1	1.050	606	1.000	Inparanoid score	I928
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55412
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005242
OrthoInspector	1	1.000	-	-		oto94240
orthoMCL	1	0.900	-	-		OOG6_103258
Panther	1	1.100	-	-	LDO	PTHR14145
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R254
SonicParanoid	1	1.000	-	-		X5623
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790