DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CSN1b and Gps1

DIOPT Version :9

Sequence 1:	NP_524152.2	Gene:	CSN1b / 40063	FlyBaseID:	FBgn0027057	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	XP_006247928.1	Gene:	Gps1 / 117039	RGDID:	621532	Length:	536	Species:	Rattus norvegicus

Alignment Length:	505	Identity:	313/505 - (61%)
Similarity:	394/505 - (78%)	Gaps:	41/505 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LMQNAVEPMQVDIAPPNEDNENNEEQQIVVENPSIDLEVYANQYAGIVRLHRLIYVADVCPVLAV 73
            |.:.||||||:|: .|.||.:|..:...|||||::|||.||..|:|::|:.||.::||.||.|.|
  Rat    48 LSEGAVEPMQIDV-DPQEDPQNAPDVNYVVENPTLDLEQYAASYSGLMRIERLQFIADRCPPLRV 111

  Fly    74 EALKMAITYVQTTYNVNLYQVLHKRLSDLNAGNAPAPPANAGGDQAGAAAPGPLAAAPLPDIAAQ 138
            ||||||:::||.|:||::|:.:|::||:.......||.|                   :|:...:
  Rat   112 EALKMALSFVQRTFNVDMYEEIHRKLSEATRELQNAPDA-------------------IPESGVE 157

  Fly   139 PVAQAQGQAQPAVEKDAFAYDAAWVDTKMKKAALKLEKLDSDLKNYKSNSIKESIRRGHDDLADH 203
            |         |.:       |.|||:...|||.|||||||:||||||.||||||||||||||.||
  Rat   158 P---------PPL-------DTAWVEATRKKALLKLEKLDTDLKNYKGNSIKESIRRGHDDLGDH 206

  Fly   204 YLSCGDLTNALKCYSRARDYCTSGKHVVNMCLNVIKVSIYLQNWAHVMSYISKAESTPDFAE-GS 267
            ||.||||:|||||||||||||||.|||:||||||||||:|||||:||:||:|||||||:.|| |.
  Rat   207 YLDCGDLSNALKCYSRARDYCTSAKHVINMCLNVIKVSVYLQNWSHVLSYVSKAESTPEIAERGE 271

  Fly   268 KEANAQ-VHTRLECAAGLAELQQKKYKVAAKHFLNANFDHCDFPEMISTSNVAVYGGLCALATFD 331
            :::..| :.|:|:||||||||..:|||.|||.||.|:||||||||::|.||||||||||||||||
  Rat   272 RDSQTQAILTKLKCAAGLAELAARKYKQAAKCFLLASFDHCDFPELLSPSNVAVYGGLCALATFD 336

  Fly   332 RQELKRLVIASTSFKLFLELEPQLRDIIFKFYESKYASCLTLLDEIRDNLLVDMYIAPHVTTLYT 396
            ||||:|.||:|:|||||||||||:||||||||||||||||.:|||::||||:|||:||||.||||
  Rat   337 RQELQRNVISSSSFKLFLELEPQVRDIIFKFYESKYASCLKMLDEMKDNLLLDMYLAPHVRTLYT 401

  Fly   397 KIRNRALIQYFSPYMSADMHKMAMAFNSSVGDLENEVMQLILDGQIQARIDSHNKILFAKEADQR 461
            :|||||||||||||:||||||||.|||::|..||:|:.||||:|.|.||||||:|||:|::.|||
  Rat   402 QIRNRALIQYFSPYVSADMHKMAAAFNTTVAALEDELTQLILEGLINARIDSHSKILYARDVDQR 466

  Fly   462 NSTFERALIMGKQYQRHTRMLVLRAAMLKSHIHVK--SISREG-GSNHGA 508
            ::|||::|:|||::||..:.::||||:|::.||||  |:..|| ||.|.|
  Rat   467 STTFEKSLLMGKEFQRRAKAMILRAAVLRNQIHVKVNSLGCEGMGSTHTA 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CSN1b	NP_524152.2	RPN7	159..338	CDD:287560	138/180 (77%)
CSN1b	NP_524152.2	PCI	353..457	CDD:279707	80/103 (78%)
Gps1	XP_006247928.1	RPN7	162..343	CDD:287560	138/180 (77%)
Gps1	XP_006247928.1	PCI	358..462	CDD:279707	80/103 (78%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353908
Domainoid	1	1.000	290	1.000	Domainoid score	I1489
eggNOG	1	0.900	-	-		E1_KOG0686
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3046
Inparanoid	1	1.050	606	1.000	Inparanoid score	I898
OMA	1	1.010	-	-		QHG55412
OrthoDB	1	1.010	-	-		D223526at33208
OrthoFinder	1	1.000	-	-		FOG0005242
OrthoInspector	1	1.000	-	-		oto97760
orthoMCL	1	0.900	-	-		OOG6_103258
Panther	1	1.100	-	-	LDO	PTHR14145
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5623
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.810