DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6843 and CIR1

DIOPT Version :9

Sequence 1:	NP_649072.1	Gene:	CG6843 / 40062	FlyBaseID:	FBgn0036827	Length:	366	Species:	Drosophila melanogaster
Sequence 2:	NP_004873.3	Gene:	CIR1 / 9541	HGNCID:	24217	Length:	450	Species:	Homo sapiens

Alignment Length:	439	Identity:	170/439 - (38%)
Similarity:	234/439 - (53%)	Gaps:	103/439 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGKGFNNYMCKKFFHPASRDNLKRVWMAEQQAEAYKKKQEELRNQYEKEQNLHENKAMLSKDSKD 65
            |||.|.|:||||.|||||:.|:|:||||||:....|||||||..||.|||..::|: :|..|.:.
Human     1 MGKSFANFMCKKDFHPASKSNIKKVWMAEQKISYDKKKQEELMQQYLKEQESYDNR-LLMGDERV 64

  Fly    66 KLSVNFMYEPPPGVR---KEREKDDNEPEYKFEWQRKYNAPRESYCKGDTEIRDQPFGIQVRNVR 127
            |..:|||||.|||.:   ||:|:.:.|.|||||||:  .||||.|.|.|..||||||||||||||
Human    65 KNGLNFMYEAPPGAKKENKEKEETEGETEYKFEWQK--GAPREKYAKDDMNIRDQPFGIQVRNVR 127

  Fly   128 CLKCHKWGHINTDKECTMYSISMSEARKLHAETEASDIMAKNVLEEQMKEDGLMMKRSAQELQSI 192
            |:|||||||:|||:||.::.:|...|..:..:.....:....::.| |:..|..:||:... :::
Human   128 CIKCHKWGHVNTDRECPLFGLSGINASSVPTDGSGPSMHPSELIAE-MRNSGFALKRNVLG-RNL 190

  Fly   193 RAIQQQHQLVPSDGEKDAHADDQNPELVFLKSLSKKQKLKLLKKLEKIERMKRKGEGIKKPTKRK 257
            .|.....:.|.|:||:|       ||:.|||||:.|||.|||:||:::|:.|:|
Human   191 TANDPSQEYVASEGEED-------PEVEFLKSLTTKQKQKLLRKLDRLEKKKKK----------- 237

  Fly   258 SKKERHEKDSKKKKSKKDKSSRKDKKGSVSNSSDSSSSS------DSSDSEDNHK---------- 306
                   ||.||||.:|.:|..|..|.|.|:||.|||||      .||:||.|:|
Human   238 -------KDRKKKKFQKSRSKHKKHKSSSSSSSSSSSSSSTETSESSSESESNNKEKKIQRKKRK 295

  Fly   307 -----------------------------SNH-----------------RDDKRNGH----QRTR 321
                                         |:|                 |:|.:..|    :::|
Human   296 KNKCSGHNNSDSEEKDKSKKRKLHEELSSSHHNREKAKEKPRFLKHESSREDSKWSHSDSDKKSR 360

  Fly   322 DSDHSYQRRSNENRHRRDRSRSRD----RSRSLSRDRRRERERRDRSRR 366
            ...||.::|.:|.:....||..|:    ||||.|....::||.|.|::|
Human   361 THKHSPEKRGSERKEGSSRSHGREERSRRSRSRSPGSYKQRETRKRAQR 409

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6843	NP_649072.1	Cir_N	13..49	CDD:287204	22/35 (63%)
CIR1	NP_004873.3	Interaction with RBPJ. /evidence=ECO:0000269\|PubMed:9874765	1..121		70/122 (57%)
		Cir_N	13..49	CDD:402000	22/35 (63%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	72..93		9/20 (45%)
		Interaction with RP9. /evidence=ECO:0000250	204..232		18/34 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	218..450		59/210 (28%)
		Nuclear localization signal. /evidence=ECO:0000255	235..245		7/27 (26%)
		Nuclear localization signal. /evidence=ECO:0000255	291..298		0/6 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144345
Domainoid	1	1.000	209	1.000	Domainoid score	I2855
eggNOG	1	0.900	-	-		E1_KOG3794
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	276	1.000	Inparanoid score	I2960
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG58189
OrthoDB	1	1.010	-	-		D1604301at2759
OrthoFinder	1	1.000	-	-		FOG0006267
OrthoInspector	1	1.000	-	-		oto89928
orthoMCL	1	0.900	-	-		OOG6_106007
Panther	1	1.100	-	-	LDO	PTHR13151
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3109
SonicParanoid	1	1.000	-	-		X5216
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800