DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6843 and Cir1

DIOPT Version :9

Sequence 1:	NP_649072.1	Gene:	CG6843 / 40062	FlyBaseID:	FBgn0036827	Length:	366	Species:	Drosophila melanogaster
Sequence 2:	NP_080130.2	Gene:	Cir1 / 66935	MGIID:	1914185	Length:	450	Species:	Mus musculus

Alignment Length:	436	Identity:	173/436 - (39%)
Similarity:	232/436 - (53%)	Gaps:	82/436 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGKGFNNYMCKKFFHPASRDNLKRVWMAEQQAEAYKKKQEELRNQYEKEQNLHENKAMLSKDSKD 65
            |||.|.|:||||.|||||:.|:|:||||||:....|||||||..||.|||..::|: :|..|.:.
Mouse     1 MGKSFANFMCKKDFHPASKSNIKKVWMAEQKISYDKKKQEELMQQYLKEQESYDNR-LLMGDERV 64

  Fly    66 KLSVNFMYEPPPGVR---KEREKDDNEPEYKFEWQRKYNAPRESYCKGDTEIRDQPFGIQVRNVR 127
            |..:|||||.||||:   ||:|:.:.|.|||||||:  .||||.|.|.|..||||||||||||||
Mouse    65 KNGLNFMYEAPPGVKKENKEKEETEGETEYKFEWQK--GAPREKYAKDDMNIRDQPFGIQVRNVR 127

  Fly   128 CLKCHKWGHINTDKECTMYSISMSEARKLHAETEASDIMAKNVLEEQMKEDGLMMKRSAQELQSI 192
            |:|||||||:|||:||.::.:|...|..:..:.....:....::.| |:..|..:||:... :::
Mouse   128 CIKCHKWGHVNTDRECPLFGLSGINASSVPTDGSGPSMHPSELIAE-MRNSGFALKRNVLG-RNL 190

  Fly   193 RAIQQQHQLVPSDGEKDAHADDQNPELVFLKSLSKKQKLKLLKKLEKIERMKRKGEGIKKPTKRK 257
            .|.......|.||.|:|       ||:.|||||:.|||.|||:||:::|:.|:|.:..||..|.:
Mouse   191 TANDPSQDYVASDCEED-------PEVEFLKSLTTKQKQKLLRKLDRLEKKKKKKKSDKKKKKLQ 248

  Fly   258 SKKERHEKDSKKKKSKKDKSSRKDKKGSVSNSSDSSSS--SDSSDSEDNHKSNHRDDKRNGHQRT 320
            ..|.:|:|...|..|....||......|.|:||.||||  ||||...||.:.....:||...::|
Mouse   249 KSKNKHKKRKNKSPSSSSSSSSSSSSSSSSSSSSSSSSETSDSSSESDNKEKKREKEKRKKKKKT 313

  Fly   321 RDSD------------------------------------------------------------H 325
            :.|:                                                            |
Mouse   314 KCSESKSSDCKEDKPKNMLYEELSSSHSDRGKAQEKLRFPKQESSGENSMWVHSASDRTSRSHRH 378

  Fly   326 SYQRR-SNENRHRRDRSRSR----DRSRSLSRDRRRERERRDRSRR 366
            |.::: |:.||..|.|||||    .||||.|..|::.||.|.|..|
Mouse   379 SPEKKGSDRNRGIRSRSRSRAESSRRSRSRSPYRQKHREVRSRPHR 424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6843	NP_649072.1	Cir_N	13..49	CDD:287204	22/35 (63%)
Cir1	NP_080130.2	Interaction with RBPJ. /evidence=ECO:0000250	1..121		71/122 (58%)
		Cir_N	13..49	CDD:287204	22/35 (63%)
		Interaction with RP9. /evidence=ECO:0000269\|PubMed:15652350	204..232		17/34 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	218..450		61/207 (29%)
		Nuclear localization signal. /evidence=ECO:0000255	235..247		4/11 (36%)
		Nuclear localization signal. /evidence=ECO:0000255	307..314		1/6 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834484
Domainoid	1	1.000	214	1.000	Domainoid score	I2727
eggNOG	1	0.900	-	-		E1_KOG3794
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	282	1.000	Inparanoid score	I2867
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG58189
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006267
OrthoInspector	1	1.000	-	-		oto93504
orthoMCL	1	0.900	-	-		OOG6_106007
Panther	1	1.100	-	-	LDO	PTHR13151
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3109
SonicParanoid	1	1.000	-	-		X5216
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.790