Protein Alignment CG6843 and Cir1

DIOPT Version :10

• Sequence 1: NP_649072.1
• Gene: CG6843 / 40062
• FlyBaseID: FBgn0036827
• Length: 366
• Species: Drosophila melanogaster
• Sequence 2: NP_080130.2
• Gene: Cir1 / 66935
• MGIID: 1914185
• Length: 450
• Species: Mus musculus
• Alignment Length: 436
• Identity: 173/436 - (39%)
• Similarity: 232/436 - (53%)
• Gaps: 82/436 - (18%)

  Fly     1 MGKGFNNYMCKKFFHPASRDNLKRVWMAEQQAEAYKKKQEELRNQYEKEQNLHENKAMLSKDSKD 65
            |||.|.|:||||.|||||:.|:|:||||||:....|||||||..||.|||..::|: :|..|.:.
Mouse     1 MGKSFANFMCKKDFHPASKSNIKKVWMAEQKISYDKKKQEELMQQYLKEQESYDNR-LLMGDERV 64

  Fly    66 KLSVNFMYEPPPGVR---KEREKDDNEPEYKFEWQRKYNAPRESYCKGDTEIRDQPFGIQVRNVR 127
            |..:|||||.||||:   ||:|:.:.|.|||||||:  .||||.|.|.|..||||||||||||||
Mouse    65 KNGLNFMYEAPPGVKKENKEKEETEGETEYKFEWQK--GAPREKYAKDDMNIRDQPFGIQVRNVR 127

  Fly   128 CLKCHKWGHINTDKECTMYSISMSEARKLHAETEASDIMAKNVLEEQMKEDGLMMKRSAQELQSI 192
            |:|||||||:|||:||.::.:|...|..:..:.....:....::.| |:..|..:||:... :::
Mouse   128 CIKCHKWGHVNTDRECPLFGLSGINASSVPTDGSGPSMHPSELIAE-MRNSGFALKRNVLG-RNL 190

  Fly   193 RAIQQQHQLVPSDGEKDAHADDQNPELVFLKSLSKKQKLKLLKKLEKIERMKRKGEGIKKPTKRK 257
            .|.......|.||.|:|       ||:.|||||:.|||.|||:||:::|:.|:|.:..||..|.:
Mouse   191 TANDPSQDYVASDCEED-------PEVEFLKSLTTKQKQKLLRKLDRLEKKKKKKKSDKKKKKLQ 248

  Fly   258 SKKERHEKDSKKKKSKKDKSSRKDKKGSVSNSSDSSSS--SDSSDSEDNHKSNHRDDKRNGHQRT 320
            ..|.:|:|...|..|....||......|.|:||.||||  ||||...||.:.....:||...::|
Mouse   249 KSKNKHKKRKNKSPSSSSSSSSSSSSSSSSSSSSSSSSETSDSSSESDNKEKKREKEKRKKKKKT 313

  Fly   321 RDSD------------------------------------------------------------H 325
            :.|:                                                            |
Mouse   314 KCSESKSSDCKEDKPKNMLYEELSSSHSDRGKAQEKLRFPKQESSGENSMWVHSASDRTSRSHRH 378

  Fly   326 SYQRR-SNENRHRRDRSRSR----DRSRSLSRDRRRERERRDRSRR 366
            |.::: |:.||..|.|||||    .||||.|..|::.||.|.|..|
Mouse   379 SPEKKGSDRNRGIRSRSRSRAESSRRSRSRSPYRQKHREVRSRPHR 424

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6843	NP_649072.1	Cir_N	14..49	CDD:462992	22/34 (65%)
Cir1	NP_080130.2	Interaction with RBPJ. /evidence=ECO:0000250	1..121		71/122 (58%)
		Cir_N	13..49	CDD:462992	22/35 (63%)
		Interaction with RP9. /evidence=ECO:0000269|PubMed:15652350	204..232		17/34 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	218..450		61/207 (29%)
		Nuclear localization signal. /evidence=ECO:0000255	235..247		4/11 (36%)
		Nuclear localization signal. /evidence=ECO:0000255	307..314		1/6 (17%)