Protein Alignment CG6843 and Cir1

DIOPT Version :10

• Sequence 1: NP_649072.1
• Gene: CG6843 / 40062
• FlyBaseID: FBgn0036827
• Length: 366
• Species: Drosophila melanogaster
• Sequence 2: NP_001007800.1
• Gene: Cir1 / 362149
• RGDID: 1309199
• Length: 451
• Species: Rattus norvegicus
• Alignment Length: 434
• Identity: 171/434 - (39%)
• Similarity: 229/434 - (52%)
• Gaps: 83/434 - (19%)

  Fly     1 MGKGFNNYMCKKFFHPASRDNLKRVWMAEQQAEAYKKKQEELRNQYEKEQNLHENKAMLSKDSKD 65
            |||.|.|:||||.|||||:.|:|:||||||:....|||||||..||.|||..::|: :|..|.:.
  Rat     1 MGKSFANFMCKKDFHPASKSNIKKVWMAEQKISYDKKKQEELMQQYLKEQESYDNR-LLMGDERV 64

  Fly    66 KLSVNFMYEPPPGVR---KEREKDDNEPEYKFEWQRKYNAPRESYCKGDTEIRDQPFGIQVRNVR 127
            |..:|||||.||||:   ||:|:.:.|.|||||||:  .||||.|.|.|..||||||||||||||
  Rat    65 KNGLNFMYEAPPGVKKENKEKEETEGETEYKFEWQK--GAPREKYAKDDMNIRDQPFGIQVRNVR 127

  Fly   128 CLKCHKWGHINTDKECTMYSISMSEARKLHAETEASDIMAKNVLEEQMKEDGLMMKRSAQELQSI 192
            |:|||||||:|||:||.::.:|...|..:..:.....:....::.| |:..|..:||:... :::
  Rat   128 CIKCHKWGHVNTDRECPLFGLSGINASSVPTDGSGPSMHPSELIAE-MRNSGFALKRNVLG-RNL 190

  Fly   193 RAIQQQHQLVPSDGEKDAHADDQNPELVFLKSLSKKQKLKLLKKLEKIERMKRKGEGIKKPTKRK 257
            .|.......|.||||:|       ||:.|||||:.|||.|||:||:::|:.|:|.:..||..|.:
  Rat   191 TANDPSQDYVASDGEED-------PEVEFLKSLTTKQKQKLLRKLDRLEKKKKKKKSDKKKKKLQ 248

  Fly   258 SKKERHEKDSKKKKSKKDKSSRKDKKGSVSNSSDSSSSSDS---SDSEDNHKSNHRDDKRNGHQR 319
            ..|.:|:|..|...|....||......|.|:||.|||:|.|   |.||.::|.....:||...::
  Rat   249 KSKNKHKKHKKSSSSSSSSSSSSSSSSSSSSSSSSSSTSSSETDSSSESDNKEKKEKEKRKKRKK 313

  Fly   320 T------------------------------------------------------------RDSD 324
            |                                                            |...
  Rat   314 TKCSGNKSGDCKEYKSKNMLYEELSSSHSDRGKAQEKLRLLKQESSGENSTWVHSGSDRKSRSHQ 378

  Fly   325 HSYQRR-SNENRHRRDRSRS----RDRSRSLSRDRRRERERRDR 363
            ||.:|: |:.|...|.|||:    |.||||....:.||||.|.|
  Rat   379 HSPERKGSDRNGGSRSRSRAEGSRRSRSRSPCGQKHREREARSR 422

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6843	NP_649072.1	Cir_N	14..49	CDD:462992	22/34 (65%)
Cir1	NP_001007800.1	Interaction with RBPJ. /evidence=ECO:0000250	1..121		71/122 (58%)
		Cir_N	13..49	CDD:462992	22/35 (63%)
		Interaction with RP9. /evidence=ECO:0000250	204..232		18/34 (53%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	213..451		62/210 (30%)
		Nuclear localization signal. /evidence=ECO:0000255	233..247		4/13 (31%)
		Nuclear localization signal. /evidence=ECO:0000255	307..315		2/7 (29%)