DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3902 and ACOX3

DIOPT Version :9

Sequence 1:	NP_649069.2	Gene:	CG3902 / 40059	FlyBaseID:	FBgn0036824	Length:	414	Species:	Drosophila melanogaster
Sequence 2:	NP_001362712.1	Gene:	ACOX3 / 8310	HGNCID:	121	Length:	700	Species:	Homo sapiens

Alignment Length:	452	Identity:	102/452 - (22%)
Similarity:	171/452 - (37%)	Gaps:	112/452 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 LTFLTDDEKMM--KETV---------------AKLAQEQIQPLVKKMDFEHKFDPSVVKAVFENG 81
            |...|:.|.|:  |:|:               |.|:.|:    .::::|..      .|.:||..
Human    35 LALFTEGEGMLRFKKTIFSALENDPLFARSPGADLSLEK----YRELNFLR------CKRIFEYD 89

  Fly    82 LMGIEIDTELGGSGCNFMTNIVV---VEELSKIDPAVAAFVDIHNTLVNSLMIKFGNAEQKAKYL 143
            .:.:| |.        |.:.:.|   ::.|...|.::||...:|:.:..|.:...| :|:...|:
Human    90 FLSVE-DM--------FKSPLKVPALIQCLGMYDSSLAAKYLLHSLVFGSAVYSSG-SERHLTYI 144

  Fly   144 PKL-AQEYAGSFALTEPGAGSDAFSLKTVAKKDGS--HYVIN-----GSKMWISN-SDVAGVFLI 199
            .|: ..|..|.|||||...||:..:::|.|..|.:  .::|:     .:|.|:.| ...|...::
Human   145 QKIFRMEIFGCFALTELSHGSNTKAIRTTAHYDPATEEFIIHSPDFEAAKFWVGNMGKTATHAVV 209

  Fly   200 FAN-AKPEDGYRGITTFIV---DRET----PGLIVNKPEDKLGIRASGTCQLTFDNVRVPEENIL 256
            ||. ..|.|...|:..|||   |.:|    ||::|.....|||..........|..||||.:::|
Human   210 FAKLCVPGDQCHGLHPFIVQIRDPKTLLPMPGVMVGDIGKKLGQNGLDNGFAMFHKVRVPRQSLL 274

  Fly   257 ---------GTFGHGYK-------YAAGFLNEGRIGIAAQMVGLAQGTFDATIPYLLERKQFGD- 304
                     ||:...:|       .:.|.|:.||:.|.:..:...:......:.:...|:|||.
Human   275 NRMGDVTPEGTYVSPFKDVRQRFGASLGSLSSGRVSIVSLAILNLKLAVAIALRFSATRRQFGPT 339

  Fly   305 ----------------------AIYNFQSMQHQIATVATEIEAARLMTYNAARLQEQGVPFQKEA 347
                                  |:|........:.....|::........:||..|.|......|
Human   340 EEEEIPVLEYPMQQWRLLPYLAAVYALDHFSKSLFLDLVELQRGLASGDRSARQAELGREIHALA 404

  Fly   348 AMAKYYASEVAQRAAIKCVDWMGG--------VGFTRDFPQEKYYRDVKIGAIYEGTTNMQL 401
            :.:|..||...|:...:|.:..||        :|..||        |......|||..|:.|
Human   405 SASKPLASWTTQQGIQECREACGGHGYLAMNRLGVLRD--------DNDPNCTYEGDNNILL 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3902	NP_649069.2	CaiA	37..414	CDD:224871	101/449 (22%)
CG3902	NP_649069.2	SCAD_SBCAD	39..410	CDD:173847	100/447 (22%)
ACOX3	NP_001362712.1	AXO	19..672	CDD:173839	102/452 (23%)
ACOX3	NP_001362712.1	Microbody targeting signal. /evidence=ECO:0000250\|UniProtKB:Q63448	698..700
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1960
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810