DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3902 and ACADSB

DIOPT Version :9

Sequence 1:	NP_649069.2	Gene:	CG3902 / 40059	FlyBaseID:	FBgn0036824	Length:	414	Species:	Drosophila melanogaster
Sequence 2:	NP_001600.1	Gene:	ACADSB / 36	HGNCID:	91	Length:	432	Species:	Homo sapiens

Alignment Length:	432	Identity:	244/432 - (56%)
Similarity:	318/432 - (73%)	Gaps:	24/432 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LKKLPVRML--ANAARQQSAAMSSATGLPP----------------------PLTFLTDDEKMMK 45
            ::.|.||:|  :...|:......|:..:||                      ||...||:|.|:|
Human     1 MEGLAVRLLRGSRLLRRNFLTCLSSWKIPPHVSKSSQSEALLNITNNGIHFAPLQTFTDEEMMIK 65

  Fly    46 ETVAKLAQEQIQPLVKKMDFEHKFDPSVVKAVFENGLMGIEIDTELGGSGCNFMTNIVVVEELSK 110
            .:|.|.|||||.|||..||...|.:.||::.:|:.||||||:|.|.||:|.:|::.::|:|||:|
Human    66 SSVKKFAQEQIAPLVSTMDENSKMEKSVIQGLFQQGLMGIEVDPEYGGTGASFLSTVLVIEELAK 130

  Fly   111 IDPAVAAFVDIHNTLVNSLMIKFGNAEQKAKYLPKLAQEYAGSFALTEPGAGSDAFSLKTVAKKD 175
            :|.:||.|.:|.|||:|:|:.|.|..||||.|||:|..|..|||.|:|.|||||:|:|||.|.|:
Human   131 VDASVAVFCEIQNTLINTLIRKHGTEEQKATYLPQLTTEKVGSFCLSEAGAGSDSFALKTRADKE 195

  Fly   176 GSHYVINGSKMWISNSDVAGVFLIFANAKPEDGYRGITTFIVDRETPGLIVNKPEDKLGIRASGT 240
            |.:||:||||||||:::.||:||:.||..|..||:|||:|:|||:||||.:.|||:|||:|||.|
Human   196 GDYYVLNGSKMWISSAEHAGLFLVMANVDPTIGYKGITSFLVDRDTPGLHIGKPENKLGLRASST 260

  Fly   241 CQLTFDNVRVPEENILGTFGHGYKYAAGFLNEGRIGIAAQMVGLAQGTFDATIPYLLERKQFGDA 305
            |.|||:||:|||.||||..|||||||.|.||||||||||||:|||||.||.||||:.||.|||..
Human   261 CPLTFENVKVPEANILGQIGHGYKYAIGSLNEGRIGIAAQMLGLAQGCFDYTIPYIKERIQFGKR 325

  Fly   306 IYNFQSMQHQIATVATEIEAARLMTYNAARLQEQGVPFQKEAAMAKYYASEVAQRAAIKCVDWMG 370
            :::||.:|||:|.|||::|||||:|||||||.|.|.||.|||:||||||||:|.:...||::|||
Human   326 LFDFQGLQHQVAHVATQLEAARLLTYNAARLLEAGKPFIKEASMAKYYASEIAGQTTSKCIEWMG 390

  Fly   371 GVGFTRDFPQEKYYRDVKIGAIYEGTTNMQLSTIAKCIKKDY 412
            |||:|:|:|.|||:||.|||.||||.:|:||:||||.|..:|
Human   391 GVGYTKDYPVEKYFRDAKIGTIYEGASNIQLNTIAKHIDAEY 432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3902	NP_649069.2	CaiA	37..414	CDD:224871	234/376 (62%)
CG3902	NP_649069.2	SCAD_SBCAD	39..410	CDD:173847	232/370 (63%)
ACADSB	NP_001600.1	CaiA	57..428	CDD:224871	232/370 (63%)
		SCAD_SBCAD	59..430	CDD:173847	232/370 (63%)
		Substrate binding. /evidence=ECO:0000269\|Ref.15	291..294		2/2 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149385
Domainoid	1	1.000	222	1.000	Domainoid score	I2608
eggNOG	1	0.900	-	-		E1_COG1960
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1216
Inparanoid	1	1.050	497	1.000	Inparanoid score	I1388
Isobase	1	0.950	-	0	Normalized mean entropy	S1951
OMA	1	1.010	-	-		QHG53594
OrthoDB	1	1.010	-	-		D331445at33208
OrthoFinder	1	1.000	-	-		FOG0000508
OrthoInspector	1	1.000	-	-		oto91138
orthoMCL	1	0.900	-	-		OOG6_102170
Panther	1	1.100	-	-	LDO	PTHR43884
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2781
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.720