DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3902 and acdh-3

DIOPT Version :9

Sequence 1:	NP_649069.2	Gene:	CG3902 / 40059	FlyBaseID:	FBgn0036824	Length:	414	Species:	Drosophila melanogaster
Sequence 2:	NP_001370606.1	Gene:	acdh-3 / 172351	WormBaseID:	WBGene00019433	Length:	419	Species:	Caenorhabditis elegans

Alignment Length:	417	Identity:	230/417 - (55%)
Similarity:	300/417 - (71%)	Gaps:	8/417 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 MNSLKKLPVRMLANAARQQSAAMSSAT------GLPPPLTFLTDDEKMMKETVAKLAQEQIQPLV 60
            |:||.:  ..:::.:|....|.||:..      .:|.||..|:::|..:..||.:.|...|:|||
Worm     1 MSSLSR--SLLISRSAAPVVATMSTKPRAHIDGHVPSPLQQLSEEESSIVGTVRRFAVNVIKPLV 63

  Fly    61 KKMDFEHKFDPSVVKAVFENGLMGIEIDTELGGSGCNFMTNIVVVEELSKIDPAVAAFVDIHNTL 125
            ::||.:.:...||:...||||||||||..:.||.|.:|...::|:|||:|:||:|:.|||:.|||
Worm    64 REMDDKSQMHQSVITGTFENGLMGIEIPEKYGGPGSSFFDAVLVIEELAKVDPSVSVFVDVQNTL 128

  Fly   126 VNSLMIKFGNAEQKAKYLPKLAQEYAGSFALTEPGAGSDAFSLKTVAKKDGSHYVINGSKMWISN 190
            |..|:|:.|..|||.|||||:..|..|||||:|.|:|||||:|||.|||||..:||:||||||:|
Worm   129 VAPLIIQLGTEEQKQKYLPKIVTEAIGSFALSETGSGSDAFALKTTAKKDGDDFVISGSKMWITN 193

  Fly   191 SDVAGVFLIFANAKPEDGYRGITTFIVDRETPGLIVNKPEDKLGIRASGTCQLTFDNVRVPEENI 255
            :..|..||:||||....||:|||.|:|||...|:.|.|.|||||||||.||.:.||||||.:.:|
Worm   194 AGHAQFFLVFANADSAKGYKGITCFLVDRNQEGVSVGKKEDKLGIRASSTCSVHFDNVRVHKSSI 258

  Fly   256 LGTFGHGYKYAAGFLNEGRIGIAAQMVGLAQGTFDATIPYLLERKQFGDAIYNFQSMQHQIATVA 320
            ||.:|.|||||...||.|||||.|||:|||||.||.|||||.:|:|||..:.:||.|||||....
Worm   259 LGEYGKGYKYAIECLNAGRIGIGAQMLGLAQGCFDQTIPYLQQREQFGQRLIDFQGMQHQIGQTR 323

  Fly   321 TEIEAARLMTYNAARLQEQGVPFQKEAAMAKYYASEVAQRAAIKCVDWMGGVGFTRDFPQEKYYR 385
            .|||||||:.|||||:::.|:||.:||||||.:||:||..|..|||:|:||||||::||.||:||
Worm   324 MEIEAARLLVYNAARMKQNGLPFVREAAMAKLFASQVATTATSKCVEWLGGVGFTKEFPVEKFYR 388

  Fly   386 DVKIGAIYEGTTNMQLSTIAKCIKKDY 412
            |.|||.|||||:|:||:||||.:..:|
Worm   389 DSKIGTIYEGTSNIQLNTIAKLVDIEY 415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3902	NP_649069.2	CaiA	37..414	CDD:224871	220/376 (59%)
CG3902	NP_649069.2	SCAD_SBCAD	39..410	CDD:173847	218/370 (59%)
acdh-3	NP_001370606.1	SCAD_SBCAD	42..412	CDD:173847	218/369 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	204	1.000	Domainoid score	I1720
eggNOG	1	0.900	-	-		E1_COG1960
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1216
Inparanoid	1	1.050	465	1.000	Inparanoid score	I856
Isobase	1	0.950	-	0	Normalized mean entropy	S1951
OMA	1	1.010	-	-		QHG53594
OrthoDB	1	1.010	-	-		D331445at33208
OrthoFinder	1	1.000	-	-		FOG0000508
OrthoInspector	1	1.000	-	-		otm14107
orthoMCL	1	0.900	-	-		OOG6_102170
Panther	1	1.100	-	-	LDO	PTHR43884
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3530
SonicParanoid	1	1.000	-	-		X2781
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	15.860