DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3902 and Acadvl

DIOPT Version :9

Sequence 1:	NP_649069.2	Gene:	CG3902 / 40059	FlyBaseID:	FBgn0036824	Length:	414	Species:	Drosophila melanogaster
Sequence 2:	NP_059062.1	Gene:	Acadvl / 11370	MGIID:	895149	Length:	656	Species:	Mus musculus

Alignment Length:	427	Identity:	138/427 - (32%)
Similarity:	222/427 - (51%)	Gaps:	26/427 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SLKKLPVRMLANAARQQSAAMSSATG-------LPPPLTFLTDDEKMMKETVAKLAQ--EQIQPL 59
            |.::.|.|     |..:|.|:....|       .|.|.....:..:.:||.|..:|:  |::...
Mouse    61 STREKPAR-----AESKSFAVGMFKGQLTIDQVFPYPSVLSEEQAQFLKELVGPVARFFEEVNDP 120

  Fly    60 VKKMDFEHKFDPSVVKAVFENGLMGIEIDTELGGSGCNFMTNIVVVEELSKIDPAVAAFVDIHNT 124
            .|. |...|.:...::.:.|.|..|:::.:||||.|.:......:.|.:...|..|:..:..|.:
Mouse   121 AKN-DALEKVEDDTLQGLKELGAFGLQVPSELGGLGLSNTQYARLAEIVGMHDLGVSVTLGAHQS 184

  Fly   125 LVNSLMIKFGNAEQKAKYLPKLAQEYA-GSFALTEPGAGSDAFSLKT--VAKKDGSHYVINGSKM 186
            :....::.:|...|:.||||::|...| .:|.||||.:|||..|:::  :....|.:|.:||||:
Mouse   185 IGFKGILLYGTKAQREKYLPRVASGQALAAFCLTEPSSGSDVASIRSSAIPSPCGKYYTLNGSKI 249

  Fly   187 WISNSDVAGVFLIFANAKPEDGYRG-----ITTFIVDRETPGLIVNKPEDKLGIRASGTCQLTFD 246
            ||||..:|.:|.:||....:|...|     ||.|:|:|...|:....||.|:||:||.|.::.||
Mouse   250 WISNGGLADIFTVFAKTPIKDAATGAVKEKITAFVVERSFGGVTHGLPEKKMGIKASNTSEVYFD 314

  Fly   247 NVRVPEENILGTFGHGYKYAAGFLNEGRIGIAAQMVGLAQGTFDATIPYLLERKQFGDAIYNFQS 311
            .|:||.||:||..|.|:|.|...||.||.|:||.:.|..:......:.:...|.||||.|:||..
Mouse   315 GVKVPSENVLGEVGDGFKVAVNILNNGRFGMAATLAGTMKSLIAKAVDHATNRTQFGDKIHNFGV 379

  Fly   312 MQHQIATVATEIEAARLMTYNAARLQEQGV-PFQKEAAMAKYYASEVAQRAAIKCVDWMGGVGFT 375
            :|.::|.:|........|.|..:...:||. .||.|||::|.:.||.|.:.|.:|:..|||:||.
Mouse   380 IQEKLARMAILQYVTESMAYMLSANMDQGFKDFQIEAAISKIFCSEAAWKVADECIQIMGGMGFM 444

  Fly   376 RDFPQEKYYRDVKIGAIYEGTTNMQLSTIA--KCIKK 410
            ::...|:..||::|..|:||..::....:|  .|:.|
Mouse   445 KEPGVERVLRDIRIFRIFEGANDILRLFVALQGCMDK 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3902	NP_649069.2	CaiA	37..414	CDD:224871	129/387 (33%)
CG3902	NP_649069.2	SCAD_SBCAD	39..410	CDD:173847	128/383 (33%)
Acadvl	NP_059062.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..33
		Catalytic. /evidence=ECO:0000250\|UniProtKB:P49748	42..483		138/427 (32%)
		VLCAD	73..482	CDD:173850	134/410 (33%)
		CaiA	95..474	CDD:224871	126/379 (33%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:P49748	462..464		0/1 (0%)
		Membrane-anchoring. /evidence=ECO:0000250\|UniProtKB:P49748	484..517
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1960
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810