DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NijB and NINJ1

DIOPT Version :9

Sequence 1:	NP_649068.1	Gene:	NijB / 40057	FlyBaseID:	FBgn0036822	Length:	181	Species:	Drosophila melanogaster
Sequence 2:	NP_004139.2	Gene:	NINJ1 / 4814	HGNCID:	7824	Length:	152	Species:	Homo sapiens

Alignment Length:	104	Identity:	38/104 - (36%)
Similarity:	65/104 - (62%)	Gaps:	9/104 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 NSYAANKNVAEGLMDIALLSANANQLRFLITYNDKASTYIYSMIMVILSLVLQLLVGIMLIFKRR 139
            |.||:.|:.||.::|||||.|||:||:.::......:.|:..::::.:|||||:.||::|||
Human    39 NHYASKKSAAESMLDIALLMANASQLKAVVEQGPSFAFYVPLVVLISISLVLQIGVGVLLIF--- 100

  Fly   140 LKRF------RNRSYERTNDLLVMGVFMITVINILLAAF 172
            |.::      ::...:..|:|....||:|.|:||.:.||
Human   101 LVKYDLNNPAKHAKLDFLNNLATGLVFIIVVVNIFITAF 139

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NijB	NP_649068.1	Ninjurin	75..172	CDD:282740	36/102 (35%)
NINJ1	NP_004139.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26
		N-terminal adhesion motif. /evidence=ECO:0000269\|PubMed:33028854	26..37
		Ninjurin	39..139	CDD:309864	36/102 (35%)
		Required to induce plasma membrane rupture. /evidence=ECO:0000250\|UniProtKB:O70131	40..69		15/28 (54%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1560683at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12316
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	5	4.980