DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3961 and FAA1

DIOPT Version :9

Sequence 1:	NP_649067.2	Gene:	CG3961 / 40056	FlyBaseID:	FBgn0036821	Length:	704	Species:	Drosophila melanogaster
Sequence 2:	NP_014962.3	Gene:	FAA1 / 854495	SGDID:	S000005844	Length:	700	Species:	Saccharomyces cerevisiae

Alignment Length:	734	Identity:	218/734 - (29%)
Similarity:	333/734 - (45%)	Gaps:	120/734 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 VAYYFATRPV----PERPLVPLEN----QSPLLEGPEQIHVSKFYKESKNGKFVSYITENVRTLY 105
            ||.|  |.||    .|....|..|    :.||:..|             |.|        ..|:|
Yeast     2 VAQY--TVPVGKAANEHETAPRRNYQCREKPLVRPP-------------NTK--------CSTVY 43

  Fly   106 QTFREGAYASNNGPCLGWRETL----------------------------TSPYQWINYDEALLR 142
            :...|....:.|...:|||:..                            .|.|.:.::|:....
Yeast    44 EFVLECFQKNKNSNAMGWRDVKEIHEESKSVMKKVDGKETSVEKKWMYYELSHYHYNSFDQLTDI 108

  Fly   143 AKNFGAGMLALGARPK--QLIGIYSQNRPEWILYEQGCYSFSLVVVPLYDTLGPDACAFIIRQTD 205
            ....|.|::.:|.:|.  ..:.:|:....:|:....|..|..:.||..|||||.......:.||.
Yeast   109 MHEIGRGLVKIGLKPNDDDKLHLYAATSHKWMKMFLGAQSQGIPVVTAYDTLGEKGLIHSLVQTG 173

  Fly   206 MQVVIVEDDGKAAMLLE--KAPRSLKIIVAIKPIRQTTLERARSRG------------------- 249
            .:.:.. |:.....|::  :|.:.:|.|:....|   :.|..|..|
Yeast   174 SKAIFT-DNSLLPSLIKPVQAAQDVKYIIHFDSI---SSEDRRQSGKIYQSAHDAINRIKEVRPD 234

  Fly   250 IQIFSFIDVEKLGAKG-NHPEV-PPTAEDLCTVCYTSGTTGNPKGVMLTHGNVVAGV----CSVI 308
            |:.|||.|:.|||.:. |..:| ||..:|||.:.||||:||.||||:|.|.||||||    .:|:
Yeast   235 IKTFSFDDILKLGKESCNEIDVHPPGKDDLCCIMYTSGSTGEPKGVVLKHSNVVAGVGGASLNVL 299

  Fly   309 LQMGDHRIRAGDVMVSFLPLAHMFERCCENGMYYVGGCVGF------YSGDIKELTNDLKMLKPT 367
            ..:|:     .|.::.||||||:||...|...:|.|.|:|:      .|..::....||:..|||
Yeast   300 KFVGN-----TDRVICFLPLAHIFELVFELLSFYWGACIGYATVKTLTSSSVRNCQGDLQEFKPT 359

  Fly   368 VMPAVPRLLNRVYDKIQNDI-SASGLKRGLF----NMAMRAKEKEIARGVLRRNGCWDKLVFKKV 427
            :|..|..:...|...|.|.| :...|.:.:|    |..:..:...|..|     |....|||||:
Yeast   360 IMVGVAAVWETVRKGILNQIDNLPFLTKKIFWTAYNTKLNMQRLHIPGG-----GALGNLVFKKI 419

  Fly   428 HQAFGGNLRLMVVGSAPLAGNVLTFMRCALGCLVLEGYGQTECTGAITLTVQGDHVPNHVGPPVS 492
            ..|.||.||.::.|.:|::.:...|: ..|.|.:|.|||.||...:.|:....:......|....
Yeast   420 RTATGGQLRYLLNGGSPISRDAQEFI-TNLICPMLIGYGLTETCASTTILDPANFELGVAGDLTG 483

  Fly   493 CNAVKLVDVPEMEYFANQNTGEVCVRGSNVFHGYYKDPEKTAEAIDSEGWHHTGDVGMWLPNGTL 557
            |..||||||.|:.|||..|.|||.:.|:||...|||:.|:|::|:.|:||..|||:|.|..||.|
Yeast   484 CVTVKLVDVEELGYFAKNNQGEVWITGANVTPEYYKNEEETSQALTSDGWFKTGDIGEWEANGHL 548

  Fly   558 RIIDRRKHIFKLSQGEYIVPEKIENIYTLSQYVNQVYVYGESLKSCIIAVVVPDTDVLKQWATEN 622
            :||||:|::.|...||||..||:|::|..::||..:.||.:..|:..:.::||:...|.:.|.:.
Yeast   549 KIIDRKKNLVKTMNGEYIALEKLESVYRSNEYVANICVYADQSKTKPVGIIVPNHAPLTKLAKKL 613

  Fly   623 NVRGTLSVLCNNKNVKE------LIMNDMLNWGKQSGLKSFEQVKDIYLHPDPFSVQNGLLTPTF 681
            .:........|.:|..|      .:.:|:|..||..||...|.:..|......::.|||.:|...
Yeast   614 GIMEQKDSSINIENYLEDAKLIKAVYSDLLKTGKDQGLVGIELLAGIVFFDGEWTPQNGFVTSAQ 678

  Fly   682 KAKRPQLKSYFKPQLEDMY 700
            |.||..:.:..|.:::.:|
Yeast   679 KLKRKDILNAVKDKVDAVY 697

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3961	NP_649067.2	LC-FACS_euk	130..701	CDD:341250	196/617 (32%)
FAA1	NP_014962.3	LC_FACS_euk1	95..685	CDD:341294	195/604 (32%)
FAA1	NP_014962.3	AFD_class_I	<217..>281	CDD:418409	24/63 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1022
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53493
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820