DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3961 and LACS1

DIOPT Version :9

Sequence 1:	NP_649067.2	Gene:	CG3961 / 40056	FlyBaseID:	FBgn0036821	Length:	704	Species:	Drosophila melanogaster
Sequence 2:	NP_001031554.1	Gene:	LACS1 / 819337	AraportID:	AT2G47240	Length:	660	Species:	Arabidopsis thaliana

Alignment Length:	639	Identity:	226/639 - (35%)
Similarity:	353/639 - (55%)	Gaps:	20/639 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 VSKFYKESKNGKFVSYITENVRTLYQTFREGA--YASNNGPCLGWRETL---TSPYQWINYDEAL 140
            |...|:...:.|....|...:.|.:..|.:..  :..||  .||||..:   ..||.|..|.|..
plant    21 VGPVYRNLLSEKGFPPIDSEITTAWDIFSKSVEKFPDNN--MLGWRRIVDEKVGPYMWKTYKEVY 83

  Fly   141 LRAKNFGAGMLALGARPKQLIGIYSQNRPEWILYEQGCYSFSLVVVPLYDTLGPDACAFIIRQTD 205
            ......|:.:.|.||.|...:|||..|.|:||:..:.|.:.:|:.||||||||..|..:|:...:
plant    84 EEVLQIGSALRAAGAEPGSRVGIYGVNCPQWIIAMEACAAHTLICVPLYDTLGSGAVDYIVEHAE 148

  Fly   206 MQVVIVEDDGKAAMLLE---KAPRSLKIIVAIKPIRQTTLERARSRGIQIFSFIDVEKLGAKGNH 267
            :..|.|:|. |...|||   |..:.||.||:...:......:|...|::.:|:||...:|.:...
plant   149 IDFVFVQDT-KIKGLLEPDCKCAKRLKAIVSFTNVSDELSHKASEIGVKTYSWIDFLHMGREKPE 212

  Fly   268 PEVPPTAEDLCTVCYTSGTTGNPKGVMLTHGNVVAGVCSVILQMG--DHRIRAGDVMVSFLPLAH 330
            ...||.|.::||:.|||||:|:||||:|||..|...|..:.|.|.  :.::...||.:|||||||
plant   213 DTNPPKAFNICTIMYTSGTSGDPKGVVLTHQAVATFVVGMDLYMDQFEDKMTHDDVYLSFLPLAH 277

  Fly   331 MFERCCENGMYYVGGCVGFYSGDIKELTNDLKMLKPTVMPAVPRLLNRVYDKIQNDI-SASGLKR 394
            :.:|..|...:..|..||:|.|::..|.:|::.||||.:..|||:..|:::.||..: ..:..:|
plant   278 ILDRMNEEYFFRKGASVGYYHGNLNVLRDDIQELKPTYLAGVPRVFERIHEGIQKALQELNPRRR 342

  Fly   395 GLFNMAMRAKEKEIARGV--LRRNGCWDKLVFKKVHQAFGGNLRLMVVGSAPLAGNVLTFMRCAL 457
            .:||...:.|...:.||.  .:.:...|.:.|:|:....||.:||:|.|.|||:..:..|:|...
plant   343 FIFNALYKHKLAWLNRGYSHSKASPMADFIAFRKIRDKLGGRIRLLVSGGAPLSPEIEEFLRVTC 407

  Fly   458 GCLVLEGYGQTECTGAITLTVQGDH-VPNHVGPPVSCNAVKLVDVPEMEY--FANQNTGEVCVRG 519
            .|.|::|||.||..|...|....:. :...||.|...|.::|.:|.||.|  ......||:|:||
plant   408 CCFVVQGYGLTETLGGTALGFPDEMCMLGTVGIPAVYNEIRLEEVSEMGYDPLGENPAGEICIRG 472

  Fly   520 SNVFHGYYKDPEKTAEAIDSEGWHHTGDVGMWLPNGTLRIIDRRKHIFKLSQGEYIVPEKIENIY 584
            ..:|.||||:||.|.|.: .:||.||||:|..||||.|:||||:|::.|||||||:..|.:|||:
plant   473 QCMFSGYYKNPELTEEVM-KDGWFHTGDIGEILPNGVLKIIDRKKNLIKLSQGEYVALEHLENIF 536

  Fly   585 TLSQYVNQVYVYGESLKSCIIAVVVPDTDVLKQWATENNVRGTLSVLCNNKNVKELIMNDMLNWG 649
            ..:..|..::|||:|.||.::|||||:.:.:.:||.:.........||:...:||.|::::.:..
plant   537 GQNSVVQDIWVYGDSFKSMLVAVVVPNPETVNRWAKDLGFTKPFEELCSFPELKEHIISELKSTA 601

  Fly   650 KQSGLKSFEQVKDIYLHPDPFSVQNGLLTPTFKAKRPQLKSYFKPQLEDMYKHL 703
            :::.|:.||.:|.:.:...||.|:..|:|.|.|.:|..|..|::.|:::||:.|
plant   602 EKNKLRKFEYIKAVTVETKPFDVERDLVTATLKNRRNNLLKYYQVQIDEMYRKL 655

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3961	NP_649067.2	LC-FACS_euk	130..701	CDD:341250	212/581 (36%)
LACS1	NP_001031554.1	PLN02430	1..660	CDD:178049	226/639 (35%)
LACS1	NP_001031554.1	LC-FACS_euk	72..652	CDD:213293	211/581 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	81	1.000	Domainoid score	I2942
eggNOG	1	0.900	-	-		E1_COG1022
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53493
OrthoDB	1	1.010	-	-		D630541at2759
OrthoFinder	1	1.000	-	-		FOG0000532
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100152
Panther	1	1.100	-	-	O	PTHR43272
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X329
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.790