DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3961 and acsl4a

DIOPT Version :9

Sequence 1:	NP_649067.2	Gene:	CG3961 / 40056	FlyBaseID:	FBgn0036821	Length:	704	Species:	Drosophila melanogaster
Sequence 2:	NP_956943.1	Gene:	acsl4a / 393622	ZFINID:	ZDB-GENE-040426-1565	Length:	706	Species:	Danio rerio

Alignment Length:	716	Identity:	221/716 - (30%)
Similarity:	351/716 - (49%)	Gaps:	82/716 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 LGSLAASVAYYFATRPVPERPL---VPLENQSPLLEGPEQIHVSKFYKESKNGKFVSYITENV-- 101
            |.||.:.:.:||.|....::.|   :..::.|...:||        |:.:  .:|.|.:|.:.
Zfish    17 LYSLLSFLPWYFLTGAQEKKALAKRLKSKSTSDQPDGP--------YRST--DRFESLVTVDFPG 71

  Fly   102 -RTLYQTFREGAYASNNGPCLGWRETL-----TSP------------YQWINYDEALLRAKNFGA 148
             .||.:.|...........|||.||.|     |.|            |:|.:|:|..:...:||:
Zfish    72 KDTLDKLFDYAVERFGKLDCLGTREVLSGDNETQPNGKVFKKLILGEYKWKSYEELDIEVSHFGS 136

  Fly   149 GMLALGARPKQLIGIYSQNRPEWILYEQGCYSFSLVVVPLYDTLGPDACAFIIRQTDM-----QV 208
            |:.|||.:||..|.|:.:.|.||::..|.|:..:..:|..|.|||.||.|:.:.::.:     .:
Zfish   137 GLAALGQQPKSTIAIFCETRAEWMITAQACFRRNFPLVTFYATLGEDAVAYGLNESGVTHLVTSI 201

  Fly   209 VIVEDDGKAAMLLEKAPRSLKIIVAIKPIRQTTLERARSRGIQIFSFIDVEKLGAKG---NHPEV 270
            .::|...|:.:|  :.| :||.|:.:......|  ....:||||.|...||:||||.   |.|.|
Zfish   202 ELLETKLKSVLL--QIP-NLKHIIYVDSKSMNT--AGFPQGIQIHSMHSVEELGAKPENLNRPIV 261

  Fly   271 PPTAEDLCTVCYTSGTTGNPKGVMLTHGNVV---AGVCSVILQMGDHRIRAGDVMVSFLPLAHMF 332
            .|...||..:.||||:||.|||||:.|.|::   ||.|..|..:|..     |..:::|||||:.
Zfish   262 KPVPSDLAVIMYTSGSTGRPKGVMIIHSNLIGGMAGQCERIPGLGPK-----DTYIAYLPLAHVL 321

  Fly   333 ERCCENGMYYVGGCVGFYSGDI---------KELTNDLKMLKPTVMPAVPRLLNRVYDKIQNDI- 387
            |...|......|..:|:.|...         |....|..:|||::|.|||.:::|:...:.:.:
Zfish   322 EMTAEISCVTYGCRIGYSSPQTLSDQSTKIKKGSKGDCSVLKPSLMAAVPEIMDRINKNVMSKVQ 386

  Fly   388 SASGLKRGLFNMAMRAKEKEIARGVLRRNGCWD----KLVFKKVHQAFGGNLRLMVVGSAPLAGN 448
            ..|.::|.||..|...|.::|.:|       :|    .::||||....|||:|:|:.|.|||:..
Zfish   387 EMSCVQRTLFKPAYDYKLEQIKKG-------YDAPLCNILFKKVRALLGGNVRMMLSGGAPLSPA 444

  Fly   449 VLTFMRCALGCLVLEGYGQTECTGAITLTVQGDHVPNHVGPPVSCNAVKLVDVPEMEYFANQN-- 511
            ...||.....|.|.:|||.||..||.|:|...|:....||.|:.|..|||.|..|..|.....
Zfish   445 TQRFMNICFCCPVGQGYGLTETCGAGTITEVADYSTGRVGAPLICCEVKLKDWAEGGYTKRDKPH 509

  Fly   512 -TGEVCVRGSNVFHGYYKDPEKTAE--AIDSEG--WHHTGDVGMWLPNGTLRIIDRRKHIFKLSQ 571
             .||:.:.|.||..|||:......:  .:|..|  |..|||:|....:|.|:|:||:|.:.||..
Zfish   510 PRGEILIGGPNVTMGYYRTEGCNNDDFFVDQNGQRWFCTGDIGEMHADGCLQIVDRKKDLVKLQA 574

  Fly   572 GEYIVPEKIENIYTLSQYVNQVYVYGESLKSCIIAVVVPDTDVLKQWATENNVRGTLSVLCNNKN 636
            |||:...|:|:......:|:.:..|..|.::.:|:.:||:...|...|.:..:.||...:||:..
Zfish   575 GEYVSLGKVESALKNCSFVDNICAYANSDQNYVISFIVPNQKKLTALANQKGIEGTWEEICNHPV 639

  Fly   637 VKELIMNDMLNWGKQSGLKSFEQVKDIYLHPDPFSVQNGLLTPTFKAKRPQLKSYFKPQLEDMYK 701
            ::..::.::........|:.||....::|.|:|::.:.||:|..||.||.:||:::...:|.||.
Zfish   640 MEREVLREIKEVANSIKLQRFEIPVMVHLSPEPWTPETGLVTDAFKLKRKELKNHYLNDIERMYG 704

  Fly   702 H 702
            |
Zfish   705 H 705

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3961	NP_649067.2	LC-FACS_euk	130..701	CDD:341250	195/614 (32%)
acsl4a	NP_956943.1	PLN02387	60..703	CDD:215217	207/659 (31%)
acsl4a	NP_956943.1	LC-FACS_euk	117..703	CDD:213293	193/602 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1022
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53493
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820