DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3961 and ACSL4

DIOPT Version :9

Sequence 1:	NP_649067.2	Gene:	CG3961 / 40056	FlyBaseID:	FBgn0036821	Length:	704	Species:	Drosophila melanogaster
Sequence 2:	XP_024308119.1	Gene:	ACSL4 / 2182	HGNCID:	3571	Length:	717	Species:	Homo sapiens

Alignment Length:	739	Identity:	222/739 - (30%)
Similarity:	357/739 - (48%)	Gaps:	94/739 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 VNHLIVSNFSY----------FWDEIDGYLYYLGGTLGTLTLGSLAASVAYYFATRPVPERPLVP 65
            :|.|..|:||.          ||.:                     .::|.....:|..::|..|
Human    21 INQLQFSSFSLSFSNWCCVTCFWKK---------------------NAMAKRIKAKPTSDKPGSP 64

  Fly    66 LENQS-----PLLEGPEQIHVSKFYKE--SKNGKFVSYITENVRTLYQTFREGAYASNNGPCLGW 123
            ..:.:     .:::.|....:.|.:..  ||.||..|..|..:      ..|......||..  :
Human    65 YRSVTHFDSLAVIDIPGADTLDKLFDHAVSKFGKKDSLGTREI------LSEENEMQPNGKV--F 121

  Fly   124 RETLTSPYQWINYDEALLRAKNFGAGMLALGARPKQLIGIYSQNRPEWILYEQGCYSFSLVVVPL 188
            ::.:...|:|:||.|...|..|||:|:.|||.:||..|.|:.:.|.||::..|.|:.::..:|.|
Human   122 KKLILGNYKWMNYLEVNRRVNNFGSGLTALGLKPKNTIAIFCETRAEWMIAAQTCFKYNFPLVTL 186

  Fly   189 YDTLGPDACAFIIRQTDMQVVIVEDDGKAAMLLEKAPRSLKIIVAIKPI---RQTTLERAR-SRG 249
            |.|||.:|....:.:::...:|.    ...:|..|...:|..|..:|.|   ....:.:|. ..|
Human   187 YATLGKEAVVHGLNESEASYLIT----SVELLESKLKTALLDISCVKHIIYVDNKAINKAEYPEG 247

  Fly   250 IQIFSFIDVEKLGAKGNHPEVP---PTAEDLCTVCYTSGTTGNPKGVMLTHGNVVAGV---CSVI 308
            .:|.|...||:||:...:..:|   ||..|:..|.||||:||.|||||:.|.|::||:   |..|
Human   248 FEIHSMQSVEELGSNPENLGIPPSRPTPSDMAIVMYTSGSTGRPKGVMMHHSNLIAGMTGQCERI 312

  Fly   309 LQMGDHRIRAGDVMVSFLPLAHMFERCCENGMYYVGGCVGF--------YSGDIKE-LTNDLKML 364
            ..:|..     |..:.:|||||:.|...|...:..|..:|:        .|..||: ...|..:|
Human   313 PGLGPK-----DTYIGYLPLAHVLELTAEISCFTYGCRIGYSSPLTLSDQSSKIKKGSKGDCTVL 372

  Fly   365 KPTVMPAVPRLLNRVYDKIQNDISASG-LKRGLFNMAMRAKEKEIARGVLRRNGCWDK-----LV 423
            |||:|.|||.:::|:|..:.:.:.... :::.||.:....|.::|.:|       :|.     |:
Human   373 KPTLMAAVPEIMDRIYKNVMSKVQEMNYIQKTLFKIGYDYKLEQIKKG-------YDAPLCNLLL 430

  Fly   424 FKKVHQAFGGNLRLMVVGSAPLAGNVLTFMRCALGCLVLEGYGQTECTGAITLTVQGDHVPNHVG 488
            ||||....|||:|:|:.|.|||:.....||.....|.:.:|||.||..||.|:|...|:....||
Human   431 FKKVKALLGGNVRMMLSGGAPLSPQTHRFMNVCFCCPIGQGYGLTESCGAGTVTEVTDYTTGRVG 495

  Fly   489 PPVSCNAVKLVDVPEMEYFANQN---TGEVCVRGSNVFHGYYKDPEKTAE--AIDSEG--WHHTG 546
            .|:.|..:||.|..|..|..|..   .||:.:.|.|:..||:|:.|||||  ::|..|  |..||
Human   496 APLICCEIKLKDWQEGGYTINDKPNPRGEIVIGGQNISMGYFKNEEKTAEDYSVDENGQRWFCTG 560

  Fly   547 DVGMWLPNGTLRIIDRRKHIFKLSQGEYIVPEKIENIYTLSQYVNQVYVYGESLKSCIIAVVVPD 611
            |:|.:.|:|.|:||||:|.:.||..|||:...|:|........::.:..:.:|.:|.:|:.|||:
Human   561 DIGEFHPDGCLQIIDRKKDLVKLQAGEYVSLGKVEAALKNCPLIDNICAFAKSDQSYVISFVVPN 625

  Fly   612 TDVLKQWATENNVRGTLSVLCNNKNVKELIMNDMLNWGKQSGLKSFEQVKDIYLHPDPFSVQNGL 676
            ...|...|.:..|.||...:|||..::..|:.::........|:.||....:.|.|:|::.:.||
Human   626 QKRLTLLAQQKGVEGTWVDICNNPAMEAEILKEIREAANAMKLERFEIPIKVRLSPEPWTPETGL 690

  Fly   677 LTPTFKAKRPQLKSYFKPQLEDMY 700
            :|..||.||.:|::::...:|.||
Human   691 VTDAFKLKRKELRNHYLKDIERMY 714

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3961	NP_649067.2	LC-FACS_euk	130..701	CDD:341250	200/603 (33%)
ACSL4	XP_024308119.1	LC-FACS_euk	127..714	CDD:213293	198/602 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1022
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53493
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820