DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3961 and ACSL3

DIOPT Version :9

Sequence 1:	NP_649067.2	Gene:	CG3961 / 40056	FlyBaseID:	FBgn0036821	Length:	704	Species:	Drosophila melanogaster
Sequence 2:	NP_001341087.1	Gene:	ACSL3 / 2181	HGNCID:	3570	Length:	720	Species:	Homo sapiens

Alignment Length:	729	Identity:	231/729 - (31%)
Similarity:	363/729 - (49%)	Gaps:	93/729 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 YLYYLGGTLGTLTLGSLAASVAYYFATRPVPERPLVPLENQ---SPLLEGPEQIHVSKFYKESKN 90
            ::::|      ::|.::...:.:||.:....|:     .|:   .|:...|:..:.|   ..|.:
Human    25 FIHFL------ISLYTILTYIPFYFFSESRQEK-----SNRIKAKPVNSKPDSAYRS---VNSLD 75

  Fly    91 GKFVSYITENVRTLYQTFREGAYASN---NGPCLGWRETLT-----------------SPYQWIN 135
            | ..|.:.....||.:.|   .||.|   |...||.||.|.                 ..|.|::
Human    76 G-LASVLYPGCDTLDKVF---TYAKNKFKNKRLLGTREVLNEEDEVQPNGKIFKKVILGQYNWLS 136

  Fly   136 YDEALLRAKNFGAGMLALGARPKQLIGIYSQNRPEWILYEQGCYSFSLVVVPLYDTLGPDACAFI 200
            |::..:||.|||.|:..||.:||..|.|:.:.|.||::..|.|:.::..:|.||.|||..|....
Human   137 YEDVFVRAFNFGNGLQMLGQKPKTNIAIFCETRAEWMIAAQACFMYNFQLVTLYATLGGPAIVHA 201

  Fly   201 IRQTDMQVVIVEDDGKAAMLLEKAPRSLKIIVAIKP-IRQTTLERAR-------SRGIQIFSFID 257
            :.:|::..:|...:     ||:   ..||.||::.| :|.......:       .:||.:.:...
Human   202 LNETEVTNIITSKE-----LLQ---TKLKDIVSLVPRLRHIITVDGKPPTWSEFPKGIIVHTMAA 258

  Fly   258 VEKLGAKG---NHPEVPPTAEDLCTVCYTSGTTGNPKGVMLTHGNVVAGVCSV---ILQMGDHRI 316
            ||.||||.   |.|...|...|:..:.||||:||.|||||::|.|::||:..:   |.::|:.
Human   259 VEALGAKASMENQPHSKPLPSDIAVIMYTSGSTGLPKGVMISHSNIIAGITGMAERIPELGEE-- 321

  Fly   317 RAGDVMVSFLPLAHMFERCCENGMYYVGGCVGF--------YSGDIKE-LTNDLKMLKPTVMPAV 372
               ||.:.:|||||:.|...|......|..:|:        .|..||: ...|..|||||:|.||
Human   322 ---DVYIGYLPLAHVLELSAELVCLSHGCRIGYSSPQTLADQSSKIKKGSKGDTSMLKPTLMAAV 383

  Fly   373 PRLLNRVYDKIQNDIS-ASGLKRGLFNMAMRAKEKEIARGVLRRNGCWDKLVFKKVHQAFGGNLR 436
            |.:::|:|..:.|.:| .|..:|.||.:|...|.::|::|  |.....|..||:||....|||:|
Human   384 PEIMDRIYKNVMNKVSEMSSFQRNLFILAYNYKMEQISKG--RNTPLCDSFVFRKVRSLLGGNIR 446

  Fly   437 LMVVGSAPLAGNVLTFMRCALGCLVLEGYGQTECTGAITLTVQGDHVPNHVGPPVSCNAVKLVDV 501
            |::.|.|||:.....||.....|.|.:|||.||..||.|::...|:....||.|:.|..:||.:.
Human   447 LLLCGGAPLSATTQRFMNICFCCPVGQGYGLTESAGAGTISEVWDYNTGRVGAPLVCCEIKLKNW 511

  Fly   502 PEMEYFANQNT------GEVCVRGSNVFHGYYKDPEKT-AEAIDSEG---WHHTGDVGMWLPNGT 556
            .|..||   ||      ||:.:.|.:|..||||:..|| |:..:.|.   |..|||:|.:.|:|.
Human   512 EEGGYF---NTDKPHPRGEILIGGQSVTMGYYKNEAKTKADFFEDENGQRWLCTGDIGEFEPDGC 573

  Fly   557 LRIIDRRKHIFKLSQGEYIVPEKIENIYTLSQYVNQVYVYGESLKSCIIAVVVPDTDVLKQWATE 621
            |:||||:|.:.||..|||:...|:|........|:.:..|..|..|.:|..|||:...|.:.|.:
Human   574 LKIIDRKKDLVKLQAGEYVSLGKVEAALKNLPLVDNICAYANSYHSYVIGFVVPNQKELTELARK 638

  Fly   622 NNVRGTLSVLCNNKNVKELIMNDMLNWGKQSGLKSFEQVKDIYLHPDPFSVQNGLLTPTFKAKRP 686
            ..::||...|||:..::..::..:......:.|:.||....|.|.|:|::.:.||:|..||.||.
Human   639 KGLKGTWEELCNSCEMENEVLKVLSEAAISASLEKFEIPVKIRLSPEPWTPETGLVTDAFKLKRK 703

  Fly   687 QLKSYFKPQLEDMY 700
            :||::::..:|.||
Human   704 ELKTHYQADIERMY 717

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3961	NP_649067.2	LC-FACS_euk	130..701	CDD:341250	207/605 (34%)
ACSL3	NP_001341087.1	AFD_class_I	30..717	CDD:418409	228/716 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1022
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53493
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820