Protein Alignment CG3961 and ACSL1

DIOPT Version :10

• Sequence 1: NP_649067.2
• Gene: CG3961 / 40056
• FlyBaseID: FBgn0036821
• Length: 704
• Species: Drosophila melanogaster
• Sequence 2: NP_001986.2
• Gene: ACSL1 / 2180
• HGNCID: 3569
• Length: 698
• Species: Homo sapiens
• Alignment Length: 694
• Identity: 337/694 - (48%)
• Similarity: 458/694 - (65%)
• Gaps: 19/694 - (2%)

  Fly    19 FSYF-WDEIDGYLYYLGGTLGTLTL---GSLAASVAYYFATRPVPERPLVPLENQSPLLEGPEQI 79
            |.|| ..|:..:..|: .||.|.||   |:.||...:::||||.|.:|...|..||..:.|....
Human     7 FRYFRMPELVDFRQYV-RTLPTNTLMGFGAFAALTTFWYATRPKPLKPPCDLSMQSVEVAGSGGA 70

  Fly    80 HVSKFYKESKNGKFVSYITENVRTLYQTFREGAYASNNGPCLGWRETLTSPYQWINYDEALLRAK 144
            ..|......:.   :.|..::|.|||:.|:.|...||||||||.|:. ..||:|::|.:....::
Human    71 RRSALLDSDEP---LVYFYDDVTTLYEGFQRGIQVSNNGPCLGSRKP-DQPYEWLSYKQVAELSE 131

  Fly   145 NFGAGMLALGAR--PKQLIGIYSQNRPEWILYEQGCYSFSLVVVPLYDTLGPDACAFIIRQTDMQ 207
            ..|:.::..|.:  |.|.|||::||||||::.||||:::|:|:||||||||.:|..:|:.:.::.
Human   132 CIGSALIQKGFKTAPDQFIGIFAQNRPEWVIIEQGCFAYSMVIVPLYDTLGNEAITYIVNKAELS 196

  Fly   208 VVIVEDDGKAAMLLE----KAPRSLKIIVAIKPIRQTTLERARSRGIQIFSFIDVEKLGAKGNHP 268
            :|.|:...||.:|||    |....|||||.:.......:||.:..|:::.|...:|.||......
Human   197 LVFVDKPEKAKLLLEGVENKLIPGLKIIVVMDAYGSELVERGQRCGVEVTSMKAMEDLGRANRRK 261

  Fly   269 EVPPTAEDLCTVCYTSGTTGNPKGVMLTHGNVVAGVCSVILQMGDHRIR--AGDVMVSFLPLAHM 331
            ..||..|||..:|:||||||||||.|:||.|:|:. ||..::..::.:.  ..|.::||||||||
Human   262 PKPPAPEDLAVICFTSGTTGNPKGAMVTHRNIVSD-CSAFVKATENTVNPCPDDTLISFLPLAHM 325

  Fly   332 FERCCENGMYYVGGCVGFYSGDIKELTNDLKMLKPTVMPAVPRLLNRVYDKIQNDISASGLKRGL 396
            |||..|..|...|..:||:.|||:.|.:|||:|:|||.|.|||||||::|:|....:.: |||.|
Human   326 FERVVECVMLCHGAKIGFFQGDIRLLMDDLKVLQPTVFPVVPRLLNRMFDRIFGQANTT-LKRWL 389

  Fly   397 FNMAMRAKEKEIARGVLRRNGCWDKLVFKKVHQAFGGNLRLMVVGSAPLAGNVLTFMRCALGCLV 461
            .:.|.:.||.|:..|::|.|..||:|:|.||..:.||.:||||.|:||::..||||:|.||||..
Human   390 LDFASKRKEAELRSGIIRNNSLWDRLIFHKVQSSLGGRVRLMVTGAAPVSATVLTFLRAALGCQF 454

  Fly   462 LEGYGQTECTGAITLTVQGDHVPNHVGPPVSCNAVKLVDVPEMEYFANQNTGEVCVRGSNVFHGY 526
            .|||||||||....||:.||....|||.|:.||.:|||||.||.|.|.:..|||||:|.|||.||
Human   455 YEGYGQTECTAGCCLTMPGDWTAGHVGAPMPCNLIKLVDVEEMNYMAAEGEGEVCVKGPNVFQGY 519

  Fly   527 YKDPEKTAEAIDSEGWHHTGDVGMWLPNGTLRIIDRRKHIFKLSQGEYIVPEKIENIYTLSQYVN 591
            .|||.|||||:|.:||.||||:|.|||||||:||||:||||||:|||||.||||||||..|:.|.
Human   520 LKDPAKTAEALDKDGWLHTGDIGKWLPNGTLKIIDRKKHIFKLAQGEYIAPEKIENIYMRSEPVA 584

  Fly   592 QVYVYGESLKSCIIAVVVPDTDVLKQWATENNVRGTLSVLCNNKNVKELIMNDMLNWGKQSGLKS 656
            ||:|:||||::.:||:||||.:.|..||.:....|:...||.||:||:.|:.||:..||.||||.
Human   585 QVFVHGESLQAFLIAIVVPDVETLCSWAQKRGFEGSFEELCRNKDVKKAILEDMVRLGKDSGLKP 649

  Fly   657 FEQVKDIYLHPDPFSVQNGLLTPTFKAKRPQLKSYFKPQLEDMY 700
            |||||.|.|||:.||:.|||||||.|||||:|::||:.|::|:|
Human   650 FEQVKGITLHPELFSIDNGLLTPTMKAKRPELRNYFRSQIDDLY 693

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3961	NP_649067.2	LC-FACS_euk	130..701	CDD:341250	297/579 (51%)
ACSL1	NP_001986.2	LC-FACS_euk	116..694	CDD:341250	297/580 (51%)