DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3961 and Acsl4

DIOPT Version :9

Sequence 1:	NP_649067.2	Gene:	CG3961 / 40056	FlyBaseID:	FBgn0036821	Length:	704	Species:	Drosophila melanogaster
Sequence 2:	XP_006257376.1	Gene:	Acsl4 / 113976	RGDID:	69401	Length:	711	Species:	Rattus norvegicus

Alignment Length:	716	Identity:	220/716 - (30%)
Similarity:	358/716 - (50%)	Gaps:	81/716 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 LTLGSLAASVAYYFAT--------------RPVPERPLVPLENQS-----PLLEGPEQIHVSKFY 85
            :|:.|....:.:||.|              :|..::|..|..:.:     .:::.|....:.|.:
  Rat    19 ITIYSALIFIPWYFLTNAKKKNAMAKRIKAKPTSDKPGSPYRSVTHFDSLAVIDIPGADTLDKLF 83

  Fly    86 KE--SKNGKFVSYITENVRTLYQTFREGAYASNNGPCLGWRETLTSPYQWINYDEALLRAKNFGA 148
            ..  :|.||..|..|..:      ..|......||..  :::.:...|:||||.|...|..|||:
  Rat    84 DHAVAKFGKKDSLGTREI------LSEENEMQPNGKV--FKKLILGNYKWINYLEVNCRVNNFGS 140

  Fly   149 GMLALGARPKQLIGIYSQNRPEWILYEQGCYSFSLVVVPLYDTLGPDACAFIIRQTD-----MQV 208
            |:.|||.:||..|.|:.:.|.||::..|.|:.::..:|.||.|||.:|....:.:::     ..|
  Rat   141 GLTALGLKPKNTIAIFCETRAEWMIAAQTCFKYNFPLVTLYATLGKEAVVHGLNESEASYLITSV 205

  Fly   209 VIVEDDGKAAMLLEKAPRSLKIIVAIKPIRQTTLERAR-SRGIQIFSFIDVEKLGAKGNHPEVP- 271
            .::|...|||:|      .:..:..|..:...|:.||. ..|::|.|...||:||:|..:..:|
  Rat   206 ELLESKLKAALL------DINCVKHIIYVDNKTINRAEYPEGLEIHSMQSVEELGSKPENSSIPP 264

  Fly   272 --PTAEDLCTVCYTSGTTGNPKGVMLTHGNVVAGV---CSVILQMGDHRIRAGDVMVSFLPLAHM 331
              ||..|:..|.||||:||.|||||:.|.|::||:   |..|..:|..     |..:.:|||||:
  Rat   265 SRPTPSDMAIVMYTSGSTGRPKGVMMHHSNLIAGMTGQCERIPGLGPK-----DTYIGYLPLAHV 324

  Fly   332 FERCCENGMYYVGGCVGF--------YSGDIKE-LTNDLKMLKPTVMPAVPRLLNRVYDKIQNDI 387
            .|...|...:..|..:|:        .|..||: ...|..:||||:|.|||.:::|:|..:.:.:
  Rat   325 LELTAEISCFTYGCRIGYSSPLTLSDQSSKIKKGSKGDCTVLKPTLMAAVPEIMDRIYKNVMSKV 389

  Fly   388 SASG-LKRGLFNMAMRAKEKEIARGVLRRNGCWDK-----LVFKKVHQAFGGNLRLMVVGSAPLA 446
            .... :::.||.:....|.::|.:|       :|.     ::||||....|||:|:|:.|.|||:
  Rat   390 QEMNYIQKTLFKIGYDYKLEQIKKG-------YDAPLCNLILFKKVKALLGGNVRMMLSGGAPLS 447

  Fly   447 GNVLTFMRCALGCLVLEGYGQTECTGAITLTVQGDHVPNHVGPPVSCNAVKLVDVPEMEYFANQN 511
            .....||.....|.:.:|||.||..||.|:|...|:....||.|:.|..:||.|..|..|..:..
  Rat   448 PQTHRFMNVCFCCPIGQGYGLTESCGAGTVTEVTDYTTGRVGAPLICCEIKLKDWQEGGYTVHDK 512

  Fly   512 ---TGEVCVRGSNVFHGYYKDPEKTAE--AIDSEG--WHHTGDVGMWLPNGTLRIIDRRKHIFKL 569
               .||:.:.|.|:..||:|:.|||||  ::|..|  |..|||:|.:.|:|.|:||||:|.:.||
  Rat   513 PNPRGEIVIGGQNISMGYFKNEEKTAEDYSVDENGQRWFCTGDIGEFHPDGCLQIIDRKKDLVKL 577

  Fly   570 SQGEYIVPEKIENIYTLSQYVNQVYVYGESLKSCIIAVVVPDTDVLKQWATENNVRGTLSVLCNN 634
            ..|||:...|:|........::.:..:.:|.:|.:|:.|||:...|...|.:..|.|:...:|||
  Rat   578 QAGEYVSLGKVEAALKNCPLIDNICAFAKSDQSYVISFVVPNQKKLTLLAQQKGVEGSWVDICNN 642

  Fly   635 KNVKELIMNDMLNWGKQSGLKSFEQVKDIYLHPDPFSVQNGLLTPTFKAKRPQLKSYFKPQLEDM 699
            ..::..|:.::........|:.||....:.|.|:|::.:.||:|..||.||.:||:::...:|.|
  Rat   643 PAMEAEILKEIREAANAMKLERFEIPIKVRLSPEPWTPETGLVTDAFKLKRKELKNHYLKDIERM 707

  Fly   700 Y 700
            |
  Rat   708 Y 708

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3961	NP_649067.2	LC-FACS_euk	130..701	CDD:341250	202/605 (33%)
Acsl4	XP_006257376.1	LC_FACS_euk1	121..696	CDD:341294	197/592 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1022
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53493
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820