Protein Alignment Uggt and KRE5

DIOPT Version :10

• Sequence 1: NP_524151.2
• Gene: Uggt / 40055
• FlyBaseID: FBgn0014075
• Length: 1548
• Species: Drosophila melanogaster
• Sequence 2: NP_014981.1
• Gene: KRE5 / 854514
• SGDID: S000005863
• Length: 1365
• Species: Saccharomyces cerevisiae
• Alignment Length: 1693
• Identity: 331/1693 - (19%)
• Similarity: 597/1693 - (35%)
• Gaps: 512/1693 - (30%)

  Fly     2 LRAVALCVSVVLIALYTPTSG----------ESSQSYPITTLINAKWTQTPLYLEIAEYLADEQA 56
            :|.:||    ||:.|..|...          ||:|.:.|                :...|.|...
Yeast     1 MRLLAL----VLLLLCAPLRAWTYSLRYGIPESAQVWSI----------------LVHLLGDVDN 45

  Fly    57 GLFWDYVSGVTKLDTVLNEYDTESQQYNAALELVKSHVSSPQL-PLLRLVVSMHSLTPRIQTHFQ 120
            .|..:....||.||   :|.|.:.........:::.......: .||.|..|::.: ..||....
Yeast    46 QLLTNLYPLVTGLD---DEIDIQENLVALTSNVLRERYDKEDVADLLELYASLYPM-GMIQHDIS 106

  Fly   121 LAEELRSSGSCQSFTFAQVGSELACSFNELQKKLEVPLAKDSLDASV--------VTYSFDHIFP 177
            ...|...:.|          |....:.|..:|..:|...| |.|.::        |...:|.:.
Yeast   107 SNAEQDDANS----------SYFVLNGNRYEKPDDVFYLK-SKDLTIQQKVPDVDVIQPYDVVI- 159

  Fly   178 GSENNTRTVVLYG--DLGSSQFRTYHKLLEKEA--NAGRIRYILRHQLAKKDKRPVRLSGYGVEL 238
            |:.:....::|||  .:..|.|..:::.|..||  ..|:.|:|.|...:        |.|
Yeast   160 GTNSEAPILILYGCPTVIDSDFEEFNRNLFMEAMNGEGKFRFIWRSTCS--------LDG----- 211

  Fly   239 HLKSTEYKSQDDAPKPEAGSTSDEDLANESDVQGFDFKVLKQKHPTLKRALDQLRQRLLQG---N 300
              ||.||......         :..|.|.|.:...         |.||:.|..:.:.:|.|   :
Yeast   212 --KSVEYPLTHPL---------EITLQNGSRMSSI---------PQLKKILYTVPKEILVGADND 256

  Fly   301 DEIAQLKAWEFQDLGLQAAAAIAEIQG-----DETLQILQYTAHNFPMLARTLLAHKVT----DG 356
            |::..|:..|.::|.|:..:.|:|...     ..||...:...:|||::::.|:  ||:    |.
Yeast   257 DQLHDLEPEELRELDLRVTSLISEFYQYKKDITATLNFTKSIVNNFPLISKQLI--KVSSVNKDI 319

  Fly   357 LRAEVKHNTEAFGRSLNVAPPDGALFINGLFFDADTMDLYSLIETLRSEMRVLESLHSNNVRGSL 421
            :.:..:.|::.|..::.      .|:|||..:...::..|:|:..|::|.:.|  |...|:...|
Yeast   320 ITSNEELNSKGFDYNML------GLYINGQNWKITSLTPYNLLTALKTEYQSL--LKITNLLQEL 376

  Fly   422 ASSLLALD--LTASSKKEFAI-----------DIR-----DTAVQWVNDIENDVQYRRWPSSVMD 468
            ..|...||  ...:...:|::           |:.     ..:|.:.||||:|.||....:||..
Yeast   377 EPSKCILDSKFLLNKFSQFSLGKLQNLQPIKMDLHTIPGFSESVIYFNDIESDPQYDELVNSVQA 441

  Fly   469 LLRPTFPGMLRNIRKNVFNLVLVVD-----------ALQPTARSVIKLSESFVIHQAPIRLGLVF 522
            ....:..|.|..|::|...::.|:|           ||....|:|..:|:.:     |.|:||:.
Yeast   442 FFDKSKFGELPEIKQNWSEIIFVIDFARLEDSEVKEALGGLVRAVNVVSQGY-----PQRVGLLP 501

  Fly   523 DARDANEDNLADYVAITCAYNYVSQKKDARAALSFLTDIYAAVG------ETKVVTKKDIVKQLT 581
            .:.|      :|...:...|...:...:.....|||..:..|.|      .:|.:...|:...|.
Yeast   502 FSSD------SDKSVVNKIYELKNSTDNLTELKSFLETMLLADGLSANAKHSKHIPVPDVFHLLD 560

  Fly   582 KEFTSLSFAKAEEFLEEDSTYDYGRELAAEFIQRLGFGDKGQPQALLNGVPMP----------SN 636
            :             |:.|.|                       ..::||...|          :.
Yeast   561 E-------------LQIDET-----------------------SIIINGEIYPFRKNAWNYLIAK 589

  Fly   637 VVTADSDFEEAIFTEIMTHTSNLQKAVYKGELTDNDVAIDYLMNQPHVMPRLNQRILSQ-EDVKY 700
            |:..|::|              ::|.:......:..:::..|::......|.|:...:. .|..|
Yeast   590 VIKKDTEF--------------IRKELSNSSPKNKQISVRDLLHYKSANLRHNKYTPNYFADSVY 640

  Fly   701 LDINGVAYKNL--GNVGVLNRLSNRDM--TATLMDNLKYFGGKKSTELIGRASLQFLTIWVFADL 761
            ..:|..|.:::  ..:|...:....::  |.||:|:   ||.
Yeast   641 SSVNNTALESVCSERIGYYTKNEEYNLLHTITLVDD---FGS----------------------- 679

  Fly   762 ETDQGRDLLTHALDYVQS-------GESVRVAFIPNTESSSASSRRNLNRLVWAAMQSLPPTQAT 819
                     .|||..:::       |..:|:..:.:........|.:|::
Yeast   680 ---------IHALKRLRNLLHTSFVGVRIRIIHVGDISDIWYQLRGSLSQ--------------- 720

  Fly   820 EQVLKWLKKPKEKIEIPTQLEDILGSTE-----LHLKMLRVYSQRVLGLN--------------- 864
                                :|.:||..     |.||.::.::.:..|||
Yeast   721 --------------------KDPIGSINTFIDALKLKKVKSHTYKKSGLNQLGLHKWLPDIPLFE 765

  Fly   865 -KSQRLVIGNGRLYGPLSSDESFDSADFALLARFSSLQYSDKVRQVLKESAQDV-----NEEFNS 923
             :....:..||| :..|..:|..::..|..:.:..:|:..|.|      .|.|:     ::|..:
Yeast   766 LQKGSFIALNGR-FIHLDQNEVPETEHFEAIIKREALRTIDSV------FALDLLFPGFSQEIIN 823

  Fly   924 DTLLKLYASLLPR---QTKTRFKLPTDLKTDHSVVKLPPKQ----ENLPHF--------DVAAVL 973
            ..|:::.:|:|.|   |....:....|..|:.|:.::...:    .||..|        |:..:|
Yeast   824 PDLIEMISSILTRLFYQGTHIYNNGIDYTTESSLPRMDLSEFFRPNNLTMFEDGKSASIDLLLIL 888

  Fly   974 DPASRAAQKLTPILILLRQVLNCQLNLYLIPVPQHSDMPVKNFYRYVVEPEVQFEANGGRSDGPL 1038
            ||.....|.:..::...|.:....:.:.|:|..:.:.:|::..|....:......:...|||
Yeast   889 DPLEERTQMILSLVEQFRPLKFVNIQVILMPTLELNIVPIRRIYVDDADIVKSITSEDSRSD--- 950

  Fly  1039 AKFSGLPANPLLTQQLQVPENWLVEAVRAVYDLDNIKLTDIGGPVHSEFDLEYLLLEGHCFDAAS 1103
                     |.:..::.||.:::|:                     :.:.::.||:|.|.|.:
Yeast   951 ---------PEVDIEMDVPNSFIVD---------------------NNYRIKKLLIELHSFSS-- 983

  Fly  1104 GAPPRGLQLVLGT--------------QSQPTLVD-TIVMANLGYFQLKANPGAWSLRLREG--- 1150
                   :.||.|              .|...::| |..|...||.|...:      :..:|
Yeast   984 -------KTVLSTGNIDGMGGVCLALVDSAGNIIDKTTTMKTFGYGQFHTD------KFLKGCYI 1035

  Fly  1151 KSADI-YAISHIEGTNTHHSAGSSEVQVLITSLRSHVVKLRVSKKPGMQQAELLSDDNEQAAQSG 1214
            ||.|. |.:... .|:.|.....|: .:.|.|.....:.:::|::|          .:|:..:.|
Yeast  1036 KSCDSRYTVQSF-STDGHPDFIPSD-SLDILSYNPQKIAVKISEEP----------THEEEYEEG 1088

  Fly  1215 MWNSIASSFGGGSANQAATDEDTETINIFSV-ASGHLYERLLRIMMVSLLKHTKSP----VKFWF 1274
            ..|                  || .||||:: .||...|.....|::|:|  :|.|    |.|:.
Yeast  1089 RNN------------------DT-IINIFTILESGPDEEERYMQMILSIL--SKCPETQKVNFFI 1132

  Fly  1275 LKNYLSPQFTDFLPHMASEYNFQYEL------VQYKWPRWLHQQTEKQRTIWGYKILFLDVLFPL 1333
            |.   .|..:|.|.......|...|:      :.|:||:||..|....|.....:.||||||.|.
Yeast  1133 LD---QPFISDTLRKSCEYINSSDEMRGNVIFLNYEWPQWLRPQRFSSRRRDVSRFLFLDVLLPQ 1194

  Fly  1334 NVRKIIFVDADAIVRTDIKELYDMDLGGAPYAYTPFCDSRKEMEGFRFWKQGYWRSHLMGRR--- 1395
            |:.|::::....:............|..||....       .|.|..:||:|||...|....
Yeast  1195 NISKVLYMSPTEVPLDPFDIFQFQGLKRAPLGLF-------RMSGDGYWKEGYWEKMLRENNLEF 1252

  Fly  1396 YHISALYVVDLKRFRKIAAGDRLRGQYQALSQDPNSLSNLDQDLPNNMIHQVAIKSLPDDWLWCQ 1460
            |.....::|:|:|||::.|||:.|..||.:|.|..||.|:.|||.||:..:|.|:.|...:
Yeast  1253 YSTEPAFLVNLERFRELDAGDKYRIHYQRISTDAMSLVNIGQDLVNNLQLEVPIRFLKGSY---- 1313

  Fly  1461 TWCSDSNFKTAKVIDLCNNPQTKEAKLTAAQRIVPEWK-----------DYDAELKTLMSRIEDH 1514
                                   :.||......|.|||           |.|...:::.|:.:|.
Yeast  1314 -----------------------KKKLVINDECVSEWKKKINKFASSPGDEDVPGESVSSKYQDS 1355

  Fly  1515 ENS 1517
            :|:
Yeast  1356 DNA 1358

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Uggt	NP_524151.2	Thioredoxin_12	40..227	CDD:465748	39/199 (20%)
		Thioredoxin_13	300..414	CDD:465749	28/122 (23%)
		Thioredoxin_14	440..692	CDD:465750	50/294 (17%)
		Thioredoxin_15	717..934	CDD:465751	36/251 (14%)
		UDP-g_GGTase	1095..1204	CDD:461910	25/127 (20%)
		Glyco_transf_24	1240..1507	CDD:436473	80/291 (27%)
KRE5	NP_014981.1	Thioredoxin_13	254..372	CDD:465749	28/127 (22%)
		Thioredoxin_14	419..>576	CDD:465750	41/203 (20%)
		Glyco_transf_24	1095..>1306	CDD:436473	70/222 (32%)