DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Uggt and EBS1

DIOPT Version :9

Sequence 1:	NP_524151.2	Gene:	Uggt / 40055	FlyBaseID:	FBgn0014075	Length:	1548	Species:	Drosophila melanogaster
Sequence 2:	NP_001323059.1	Gene:	EBS1 / 843462	AraportID:	AT1G71220	Length:	1651	Species:	Arabidopsis thaliana

Alignment Length:	1650	Identity:	559/1650 - (33%)
Similarity:	852/1650 - (51%)	Gaps:	231/1650 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LIALYTPTSGESSQS---YPITTLINAKWTQTPLYLEIAEYLADEQAGLFWDYVSGVTKLDTVLN 74
            ||.|:....|.::|:   ..:...:.|||..|||.||..|.::.|...|||::.......|.  :
plant    51 LILLFIVVVGVNAQNRRPKNVQVAVKAKWQGTPLLLEAGELISKESKQLFWEFTDAWLGSDG--D 113

  Fly    75 EYDTESQQYNAALELVK---SHVSSPQLPLLRLVVSMHSLTPRIQTHFQLAEELRSS-------- 128
            :.|.:|.: :..|::.|   :.::.|...|....:::.|.:||:..:.|||:|..||
plant   114 DSDCKSAR-DCLLKISKQASTLLAQPVASLFHFSLTLRSASPRLVLYRQLADESLSSFPHGDDPS 177

  Fly   129 --GSCQSFTFAQVGSELACSFNELQKKL-EVPLAKDSLDASVVTYSFDHIFPGSENNTRTVVLYG 190
              |.|    :...||.|.....:||..| ..|...|::....: :.|||:...|...:...||||
plant   178 ATGCC----WVDTGSSLFYDVADLQSWLASAPAVGDAVQGPEL-FDFDHVHFDSRAGSPVAVLYG 237

  Fly   191 DLGSSQFRTYHKLLEKEANAGRIRYILRHQL---AKKDKRP---------VRLSGYGVELHLKST 243
            .:|:..||.:|..|.|.|..|::.|::|..|   .:...||         |.|:||||||.||:.
plant   238 AVGTDCFRKFHLSLAKAAKEGKVTYVVRPVLPLGCEGKTRPCGAIGARDNVSLAGYGVELALKNM 302

  Fly   244 EYKSQDDAPKPEAGSTSD---EDLANESDVQGFDFKVLKQKHPTLKRALDQLRQRLLQG--NDEI 303
            |||:.||:...:..:..|   |||:  .||:||.|..:..:.|.|:..:...|..||..  :|
plant   303 EYKAMDDSAIKKGITLEDPRTEDLS--QDVRGFIFSKILDRKPELRSEVMAFRDYLLSSTVSD-- 363

  Fly   304 AQLKAWEFQDLGLQAAAAIAEIQGDETLQILQYTAHNFPMLARTLLAHKVTDGLRAEVKHNTEAF 368
             .|..||.:|||.|.|..|  :...:.||.:|....|||.:..:|...|:.:.::.|:..|.
plant   364 -TLDVWELKDLGHQTAQRI--VHASDPLQSMQEINQNFPSVVSSLSRMKLNESIKDEILSNQ--- 422

  Fly   369 GRSLNVAPPDGALF-INGLFFDADTMDLYSLIETLRSEMRVLESLHSNNVR---GSLASSLLALD 429
                .:.||..||. :||...:.:.:|||.|::....|:.:..  |.:.::   |::...||...
plant   423 ----RMVPPGKALLALNGALLNIEDIDLYMLMDLAHQELSLAN--HFSKLKIPDGAIRKLLLTTP 481

  Fly   430 LTASSKKEFAIDIRDTAVQWVNDIENDVQYRRWPSSVMDLLRPTFPGMLRNIRKNVFNLVLVVDA 494
            |  .....:.:|.|...|.::|::|.|..|:||.|::.::|.|.|||.||.||||:|:.|.|:|.
plant   482 L--PEPDSYRVDFRSVHVTYLNNLEEDDMYKRWRSNINEILMPAFPGQLRYIRKNLFHAVYVIDP 544

  Fly   495 LQPTARSVIKLSESFVIHQAPIRLGLVFDAR------DANEDNLADYVAITCA------------ 541
            ........|:...|...:|.|:|.|::..:.      :.|...:....|:|.|
plant   545 ATACGLESIETLRSLYENQLPVRFGVILYSTQLIKTIENNGGQIPSSDAVTNAQVKEDLSTMVIR 609

  Fly   542 -YNYVSQKKDARAALSFLTDIYAAVGETKVVTKKDIVKQ-LTKEFTSLSFAKAEEF-------LE 597
             :.|:.:....:.|..||.::.....|:...::.||.:: :...|......|.:..       |.
plant   610 LFLYIKEHHGIQTAFQFLGNLNTLRTESADSSEADIEQEHVDGAFVETILPKVKTLPQDILLKLR 674

  Fly   598 EDSTYDYGRELAAEFIQRLGFGDKGQPQALLNGVPMPSNVVTADSDFEEAIFTEIMTHTSNLQKA 662
            ::.|.....|.::.|:.:||.. |.:...|:||       :..||..||.:...:......:|:.
plant   675 QEHTLKEASEASSMFVFKLGLA-KLKCSFLMNG-------LVFDSVEEETLLNAMNEELPKIQEQ 731

  Fly   663 VYKGELTDNDVAIDYLMNQPHVMPRLNQRILS--QEDVKYLDINGVAYKNLGNVGVLNRLSNRDM 725
            ||.|::..:...:|.|:::.. :.|.|.:|:|  :...:::.:.....|.
plant   732 VYYGQIESHTKVLDKLLSESG-LSRYNPQIISGGKNKPRFVSLASSTRKG--------------- 780

  Fly   726 TATLMDNLKYFGGKKSTELIGRASLQFLTIWVFADLETDQGRDLLTHALDYVQSG-ESVR----- 784
             .::::::.|....:::|     .::::|..:.||:.|.:|..||...:.|:..| :|.|
plant   781 -ESMLNDVNYLHSPETSE-----DVKYVTHLLAADVATKKGMKLLHEGVRYLIGGSKSARLGVLF 839

  Fly   785 -------------VAFIPNTESSSASSRRNL------------NRLVWAAMQSLPPTQATEQVLK 824
                         :.|...|.||.:...:.|            ..|:..:::|.......::||
plant   840 SSSQNADPHSLLFIKFFEKTASSFSHKEKVLYFLDKLCLFYEREYLLKTSVESASSQMFIDKVL- 903

  Fly   825 WLKKPKEKIEIPTQLEDILGST-------------ELHLKMLRVYSQRV---LGLNKSQRLVIGN 873
                         :|.|..|.:             |..||.|...:|.:   |||......:|.|
plant   904 -------------ELADEYGLSSKAYRSCLVESVDEELLKRLTKVAQFLSWELGLESDANAIISN 955

  Fly   874 GRLYGPLSSDESFDSADFALLARFSSLQYSDKVR--QVLKESA--QDVN-----EEFNSDTLLKL 929
            ||:..|: .:.:|...|..||   .|::::.:|:  |.:.|..  |||:     .::.||..:.:
plant   956 GRVIFPV-DERTFLGQDLHLL---ESMEFNQRVKPVQEIIEGIEWQDVDPDLLTSKYFSDVFMFV 1016

  Fly   930 YASLLPRQTKT---RFKLPTDLKTDHSVVKLPPKQENLPHFDVAAVLDPASRAAQKLTPILILLR 991
            .:::..|...:   ||::   |.:::|.|.|..:...: |.|  ||:||.|...|||..:|.:|:
plant  1017 SSAMATRDRSSESARFEV---LNSEYSAVLLGNENATI-HID--AVIDPLSPTGQKLASLLQVLQ 1075

  Fly   992 QVLNCQLNLYLIPVPQHSDMPVKNFYRYVVEPEVQFEANGGRSDGPLAKFSGLPANPLLTQQLQV 1056
            :.:...:.:.|.|:....|:|:||:||||:.....:.:.|...|||.|.|:.:|.:..||..|.|
plant  1076 KHVQTSMRIVLNPMSSLVDIPLKNYYRYVLPNTDDYSSTGFDVDGPKAFFANMPLSKTLTMNLDV 1140

  Fly  1057 PENWLVEAVRAVYDLDNIKLTDIGG--PVHSEFDLEYLLLEGHCFDAASGAPPRGLQLVLGTQSQ 1119
            ||.||||.|.|::|||||.|.::|.  .:.:.|::|.|:|.|||.:....| ||||||:|||:::
plant  1141 PEPWLVEPVIAIHDLDNILLENLGDTTTLQAVFEVESLVLTGHCAEKDHEA-PRGLQLILGTKNR 1204

  Fly  1120 PTLVDTIVMANLGYFQLKANPGAWSLRLREGKSADIYAISHIEGTNTHHSAGSSEVQVLITSLRS 1184
            |.||||:|||||||:|:|.:||.|.|:|..|:|:::||   ::|.|......||..::.|..||.
plant  1205 PHLVDTLVMANLGYWQMKVSPGVWYLQLAPGRSSELYA---LKGGNDGSQDQSSLKRITIDDLRG 1266

  Fly  1185 HVVKLRVSKKPGMQQAELL----SDDNEQAAQSGMWNS----IASSFGGGSANQAATDEDTE--- 1238
            .||.|.|.|:.|.:..:||    .||..|..:.|.|||    .||.|.||.........|.|
plant  1267 KVVHLEVVKRKGKEHEKLLVPSDGDDAVQQNKEGSWNSNFLKWASGFVGGRQQSMKGGPDKEHEK 1331

  Fly  1239 ------TINIFSVASGHLYERLLRIMMVSLLKHTKSPVKFWFLKNYLSPQFTDFLPHMASEYNFQ 1297
                  ||||||:||||||||.|:||::|:||:|..||||||:||||||||.|.:||||.||||:
plant  1332 GGRQGKTINIFSIASGHLYERFLKIMILSVLKNTNRPVKFWFIKNYLSPQFKDVIPHMAQEYNFE 1396

  Fly  1298 YELVQYKWPRWLHQQTEKQRTIWGYKILFLDVLFPLNVRKIIFVDADAIVRTDIKELYDMDLGGA 1362
            |||:.||||.|||:|.||||.||.||||||||:|||::.|:||||||.|:|||:.||||||:.|.
plant  1397 YELITYKWPSWLHKQKEKQRIIWAYKILFLDVIFPLSLEKVIFVDADQIIRTDMGELYDMDIKGR 1461

  Fly  1363 PYAYTPFCDSRKEMEGFRFWKQGYWRSHLMGRRYHISALYVVDLKRFRKIAAGDRLRGQYQALSQ 1427
            |.|||||||:.:||:|::|||||:|:.||.||.|||||||||||.:||:.||||.||..|:.||:
plant  1462 PLAYTPFCDNNREMDGYKFWKQGFWKEHLRGRPYHISALYVVDLVKFRETAAGDNLRVFYETLSK 1526

  Fly  1428 DPNSLSNLDQDLPNNMIHQVAIKSLPDDWLWCQTWCSDSNFKTAKVIDLCNNPQTKEAKLTAAQR 1492
            ||||||||||||||...|.|.|.|||.:||||::||.::....|:.|||||||.|||.||..|:|
plant  1527 DPNSLSNLDQDLPNYAQHTVPIFSLPQEWLWCESWCGNATKAKARTIDLCNNPMTKEPKLQGARR 1591

  Fly  1493 IVPEWKDYDAELKTLMSRI--EDHE 1515
            ||.||.|.|.|.:...::|  ||.|
plant  1592 IVTEWPDLDLEARKFTAKILGEDVE 1616

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Uggt	NP_524151.2	UDP-g_GGTase	29..1196	CDD:283964	352/1291 (27%)
		RfaJ	1238..>1456	CDD:224359	154/226 (68%)
		GT8_HUGT1_C_like	1240..1487	CDD:133054	169/246 (69%)
EBS1	NP_001323059.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	401	1.000	Domainoid score	I136
eggNOG	1	0.900	-	-		E1_KOG1879
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10586
Inparanoid	1	1.050	810	1.000	Inparanoid score	I84
OMA	1	1.010	-	-		QHG55769
OrthoDB	1	1.010	-	-		D231263at2759
OrthoFinder	1	1.000	-	-		FOG0002023
OrthoInspector	1	1.000	-	-		oto3577
orthoMCL	1	0.900	-	-		OOG6_101176
Panther	1	1.100	-	-	LDO	PTHR11226
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1498
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840