Protein Alignment Uggt and Uggt2

DIOPT Version :10

• Sequence 1: NP_524151.2
• Gene: Uggt / 40055
• FlyBaseID: FBgn0014075
• Length: 1548
• Species: Drosophila melanogaster
• Sequence 2: NP_001074721.2
• Gene: Uggt2 / 66435
• MGIID: 1913685
• Length: 1504
• Species: Mus musculus
• Alignment Length: 1564
• Identity: 640/1564 - (40%)
• Similarity: 929/1564 - (59%)
• Gaps: 118/1564 - (7%)

  Fly     1 MLRAVALCVSVVLIALYTPTSGESSQSYPITTLINAKWTQTPLYLEIAEYLADEQAGLFWDYVSG 65
            :||:|||.::  |:...|.|:.::     :|..:.|||.:|||.||.:|::|:|....||.:|..
Mouse     4 LLRSVALWLA--LLGASTATASKA-----VTAHLTAKWPETPLLLEASEFMAEESNEKFWQFVET 61

  Fly    66 VTKLDTVLNEYDTESQQYNAALELVKSHVSSPQLPLLRLVVSMHSLTPRIQTHFQLAEELRSSGS 130
            |.:| .|..:.:::...||..|:.....:.:..:.||:...|:.:.:|.||...|:|.:......
Mouse    62 VREL-AVYKQTESDYSYYNLILKKAGQFLDNIHINLLKFAFSIRAYSPTIQMFQQMAADEPPPEG 125

  Fly   131 CQSFTFAQVGSELACSFNELQKKLEVPLAKDSLDASVVTYSF--DHIFPGSENNTRTVVLYGDLG 193
            |.:|..  :.::..|..||::|.|...:::..      .|.|  ||.||.|.:|...:|||.::|
Mouse   126 CTAFVV--IHTKCTCKVNEIKKLLNKAVSRPR------PYLFERDHKFPTSSDNLPVIVLYAEIG 182

  Fly   194 SSQFRTYHKLLEKEANAGRIRYILRHQLAKKDKRPVRLSGYGVELHLKSTEYKSQDDAPKPEAGS 258
            :..|..:|::|.|::..|:|.|:|||.:.|...|.:.||||||||.:|.||||:.||.   :..:
Mouse   183 TRAFAEFHRVLSKKSKNGKILYVLRHYIQKPSSRKMYLSGYGVELAIKDTEYKALDDT---QIKT 244

  Fly   259 TSDEDLANES---DVQGFDFKVLKQKHPTLKRALDQLRQRLLQGNDEIAQLKAWEFQDLGLQAAA 320
            |:|.|:.||:   :||||.|..||:.:..||..|...::.|::.:.|:..||.||.|||..|||.
Mouse   245 TTDTDIENETEVDEVQGFLFGKLKEIYSDLKDNLTIFQKYLIESSKEMTPLKVWELQDLSFQAAT 309

  Fly   321 AIAEIQGDETLQILQYTAHNFPMLARTLLAHKVTDGLRAEVKHNTEAFGRSLNVAPPDGALFING 385
            .|......:.:::::..:.|||:.||||....|.:.:|.|::.|.:.......:.|.|..|||||
Mouse   310 QIVSTPVYDAIKLMKDISQNFPVKARTLTRIAVNELMRKEIQENQKDLRDRFEIKPGDARLFING 374

  Fly   386 LFFDADTMDLYSLIETLRSEMRVLESLHSNNVRGSLASSLLALDLTASSKK------------EF 438
            |..|.|..|.:|:::.|:||             |.|.|.|.:|.|:...:.            :|
Mouse   375 LRVDVDVYDPFSILDMLKSE-------------GKLLSGLKSLGLSEEERNRFLKLNSPVWDHDF 426

  Fly   439 AIDIRDTAVQWVNDIENDVQYRRWPSSVMDLLRPTFPGMLRNIRKNVFNLVLVVDALQPTARSVI 503
            .:|||.:::.|:||:|||..|..||||..:.|:|...|.:.::|:|..||||.:|..|......|
Mouse   427 VLDIRHSSIVWINDLENDGLYIDWPSSCWEFLKPVLHGTVPSVRRNFHNLVLFIDPAQEYTLDFI 491

  Fly   504 KLSESFVIHQAPIRLGLVFDARDANE-DNLADY-VAITCAYNYVSQKKDARAALSFLTDIYAAVG 566
            .|:|.|..::.|:|:|.||.....|| |...|. ||:..|:||:.:|.|...|...:|.:|..|.
Mouse   492 NLAEFFYFNEIPLRIGFVFILNVDNEVDGTTDAGVALWRAFNYIEEKYDVSEAFISMTHMYQEVK 556

  Fly   567 ETKVVTKKDIVKQLTKEFTSLSFAKAEEFLEEDSTYDYGRELAAEFIQRLGFGDKGQPQALLNGV 631
            ..:::| .|.||.:.:  .....|...:.|...|.||..|...|.|.:..|.|.  .||||.||.
Mouse   557 GHRILT-VDEVKSILQ--NKCPHADILDILGIHSKYDGRRMEGATFYKMTGLGP--LPQALYNGE 616

  Fly   632 PMPSNVVTADSDFEEAIFTEIMTHTSNLQKAVYKGELTDNDVAIDYLMNQPHVMPRLNQRILSQE 696
            |.....:..: :.:.|:..:::....:||:.|:.|.:.|...|||:||::.:|:.|||..|| |.
Mouse   617 PFDLKEMNTE-ELKGAVLEKMVGTFVDLQRDVFMGTIRDETSAIDFLMDKSNVVSRLNSLIL-QT 679

  Fly   697 DVKYLD-INGVAYKNLGNVGVLNRLSNRDMTATLMDNLKYFGGKKSTELIGRASLQFLTIWVFAD 760
            :.:||: ::.....::.:....:.|.::|.:|.:..::.|...:.       |.:..:|:|:.||
Mouse   680 EPQYLNLLSSSVTADIEDFSTFSFLDSQDKSAVIAKHMHYVTQED-------AVISPVTLWIIAD 737

  Fly   761 LETDQGRDLLTHALDYVQSGESVRVAFIPN-----TESSSASSRRNL-------NRLVWAAMQSL 813
            .:...||.||.:||.::::....|:..:.|     .|.|:..||..|       |:.:.:.::.|
Mouse   738 FDVPSGRKLLFNALKHMETSFHSRLGIVYNPTSKINEESTVISRGILAAFLTHKNKHLRSFLRRL 802

  Fly   814 PPTQATEQVLKWLKKPKEKIEIPTQLEDILGSTELHLKML--------RVYSQRVLGLNKSQRLV 870
            ...:..|.:..     .:|::....:|....:.|.....:        :::.|.||.|...:..:
Mouse   803 AEEETAEAIYS-----GDKVQTFLAVEMDKNAFEKKYNTVGVNIFRTHQLFCQDVLKLRPGEPGI 862

  Fly   871 IGNGRLYGPLSSDESFDSADFALLARFSSLQYSDKVRQV--LKESAQDVNEEFNSDTLLK---LY 930
            |.||:..||| |||.:.. ||.||.:   :.:|:.::.:  :.|| .|:|.:..||.::|   |.
Mouse   863 ISNGKFLGPL-SDELYQE-DFHLLEK---ITFSNSLQNIAGIVES-MDMNSKHMSDLVMKIDGLM 921

  Fly   931 ASLLPRQTKTRFKLPTDLKTDHSVVKLPPKQENLPHFDVAAVLDPASRAAQKLTPILILLRQVLN 995
            :||..|.::....|   ||.:.||:|:.| .||...|||.|::||.:|.|||:...|::|.:::|
Mouse   922 SSLAVRASRYDVTL---LKENLSVIKINP-PENDTFFDVFAIVDPLTREAQKMAQFLVVLGKIVN 982

  Fly   996 CQLNLYLIPVPQHSDMPVKNFYRYVVEPEVQFEANGGRSDGPLAKFSGLPANPLLTQQLQVPENW 1060
            .::.|::....:.|:.|:.:|||:|:|||:....|...|.||:|||..:|.:.|||..:..||.|
Mouse   983 ARIKLFMNCRGKLSEAPLDSFYRFVLEPELTSGPNNRPSHGPVAKFLDIPESHLLTLNMITPEGW 1047

  Fly  1061 LVEAVRAVYDLDNIKLTDIGGPVHSEFDLEYLLLEGHCFDAASGAPPRGLQLVLGTQSQPTLVDT 1125
            |||.|.:..|||||.|.|....|.:|::||||||||||||..:..||:|||..|||:|.|.:|||
Mouse  1048 LVETVHSNCDLDNINLKDTERSVTAEYELEYLLLEGHCFDMTTEQPPQGLQFTLGTRSNPVVVDT 1112

  Fly  1126 IVMANLGYFQLKANPGAWSLRLREGKSADIYAISHIEGTNTHHSAGSSEVQVLITSLRSHVVKLR 1190
            ||||||||||||||||||.|:||||||.|||.|:..||.....:.|:  |.|::.:.:|.::|::
Mouse  1113 IVMANLGYFQLKANPGAWILKLREGKSEDIYEITGHEGAEPETNVGN--VIVVLNTFKSKILKIQ 1175

  Fly  1191 VSKKPGMQQAELLSDDNEQAAQSGMWNSIASSFGGGSANQAATDE--DTETINIFSVASGHLYER 1253
            |.||.|..|.::|:|.:|   ..|||:||.|     .......||  :.:.:|||||||||||||
Mouse  1176 VKKKSGKIQEDVLADKHE---NRGMWDSIKS-----FTKSLHKDEKKENDILNIFSVASGHLYER 1232

  Fly  1254 LLRIMMVSLLKHTKSPVKFWFLKNYLSPQFTDFLPHMASEYNFQYELVQYKWPRWLHQQTEKQRT 1318
            .|||||:|:|::|::|||||||||||||.|.:.:||||.||.|||||||||||.||||||:|||.
Mouse  1233 FLRIMMLSVLRNTETPVKFWFLKNYLSPTFKEVIPHMAKEYGFQYELVQYKWPHWLHQQTDKQRI 1297

  Fly  1319 IWGYKILFLDVLFPLNVRKIIFVDADAIVRTDIKELYDMDLGGAPYAYTPFCDSRKEMEGFRFWK 1383
            |||||||||||||||.|.|:||||||.|||.|:|||.|.|||||||.||||||||.||:|:||||
Mouse  1298 IWGYKILFLDVLFPLAVDKVIFVDADQIVRHDLKELRDFDLGGAPYGYTPFCDSRTEMDGYRFWK 1362

  Fly  1384 QGYWRSHLMGRRYHISALYVVDLKRFRKIAAGDRLRGQYQALSQDPNSLSNLDQDLPNNMIHQVA 1448
            .|||.|||:.|:||||||||||||:||:|:|||||||||||||||||||||||||||||||:|||
Mouse  1363 TGYWASHLVKRKYHISALYVVDLKKFRRISAGDRLRGQYQALSQDPNSLSNLDQDLPNNMIYQVA 1427

  Fly  1449 IKSLPDDWLWCQTWCSDSNFKTAKVIDLCNNPQTKEAKLTAAQRIVPEWKDYDAELKTLMSRIED 1513
            |||||.|||||:|||.|.:.:.||.|||||||:|||.||.||.||||||..||.|::||:..:|:
Mouse  1428 IKSLPQDWLWCETWCDDESKQRAKTIDLCNNPKTKEPKLEAAARIVPEWVTYDTEIRTLLDHLEN 1492

  Fly  1514 HENS 1517
            .:.|
Mouse  1493 KKKS 1496

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Uggt	NP_524151.2	Thioredoxin_12	40..227	CDD:465748	55/188 (29%)
		Thioredoxin_13	300..414	CDD:465749	38/113 (34%)
		Thioredoxin_14	440..692	CDD:465750	85/253 (34%)
		Thioredoxin_15	717..934	CDD:465751	55/241 (23%)
		UDP-g_GGTase	1095..1204	CDD:461910	60/108 (56%)
		Glyco_transf_24	1240..1507	CDD:436473	209/266 (79%)
Uggt2	NP_001074721.2	Thioredoxin_12	36..217	CDD:465748	55/189 (29%)
		Thioredoxin_13	287..>394	CDD:465749	36/106 (34%)
		Thioredoxin_14	428..676	CDD:465750	85/253 (34%)
		Thioredoxin_15	700..922	CDD:465751	54/239 (23%)
		UDP-g_GGTase	1083..1189	CDD:461910	59/107 (55%)
		Glyco_transf_24	1220..1486	CDD:436473	209/265 (79%)