DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Uggt and UGGT1

DIOPT Version :9

Sequence 1:	NP_524151.2	Gene:	Uggt / 40055	FlyBaseID:	FBgn0014075	Length:	1548	Species:	Drosophila melanogaster
Sequence 2:	NP_064505.1	Gene:	UGGT1 / 56886	HGNCID:	15663	Length:	1555	Species:	Homo sapiens

Alignment Length:	1572	Identity:	687/1572 - (43%)
Similarity:	950/1572 - (60%)	Gaps:	110/1572 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LRAVALC----VSVVLIALYTPTSGESSQSYPITTLINAKWTQTPLYLEIAEYLADEQAGLFWDY 62
            |....:|    |.|||..|:. .|...:.|..|||.:..||..|||.||.:|:||::....||::
Human    16 LPVTGVCYKMGVLVVLTVLWL-FSSVKADSKAITTSLTTKWFSTPLLLEASEFLAEDSQEKFWNF 79

  Fly    63 VSGVTKLDTVLNEYD-TESQQYNAALELVKSHVSSPQLPLLRLVVSMHSLTPRIQTHFQLAEELR 126
            |.....:.:  :::| |:...|:|.||.....:|..|..|.:..:|:.|.:..||...|:|.:..
Human    80 VEASQNIGS--SDHDGTDYSYYHAILEAAFQFLSPLQQNLFKFCLSLRSYSATIQAFQQIAADEP 142

  Fly   127 SSGSCQSFTFAQVGSELACSFNELQKKLEVPLAKDSLDASVVT---------YSFDHIFPGSENN 182
            ....|.|| |:..|.: .|.             .|:|:|.::|         :..||.:|.|...
Human   143 PPEGCNSF-FSVHGKK-TCE-------------SDTLEALLLTASERPKPLLFKGDHRYPSSNPE 192

  Fly   183 TRTVVLYGDLGSSQFRTYHKLLEKEANAGRIRYILRHQLAKKDKRPVRLSGYGVELHLKSTEYKS 247
            :..|:.|.::||.:|..:|:.|..::|||:|.|:.||.:....|.||.||||||||.:||||||:
Human   193 SPVVIFYSEIGSEEFSNFHRQLISKSNAGKINYVFRHYIFNPRKEPVYLSGYGVELAIKSTEYKA 257

  Fly   248 QDDAPKPEAGSTSDEDLANESD----VQGFDFKVLKQKHPTLKRALDQLRQRLLQGNDEIAQLKA 308
            :||.  ...|:..:..:..|:|    ||||.|..|:..||.|:..|.:||:.|::..:|:|.||.
Human   258 KDDT--QVKGTEVNTTVIGENDPIDEVQGFLFGKLRDLHPDLEGQLKELRKHLVESTNEMAPLKV 320

  Fly   309 WEFQDLGLQAAAAIAEIQGDETLQILQYTAHNFPMLARTLLAHKVTDGLRAEVKHNTEAFGRSLN 373
            |:.|||..|.||.|.....:..|.:::..:.|||..||.:....|:..||.||:.|.:.|..:|.
Human   321 WQLQDLSFQTAARILASPVELALVVMKDLSQNFPTKARAITKTAVSSELRTEVEENQKYFKGTLG 385

  Fly   374 VAPPDGALFINGLFFDADTMDLYSLIETLRSEMRVLESLHSNNVRGSLASSLLALDLTASSKKEF 438
            :.|.|.|||||||..|.||.|::||.:.||:|.||:|.||...:.|....::|.|:: ..|:.::
Human   386 LQPGDSALFINGLHMDLDTQDIFSLFDVLRNEARVMEGLHRLGIEGLSLHNVLKLNI-QPSEADY 449

  Fly   439 AIDIRDTAVQWVNDIENDVQYRRWPSSVMDLLRPTFPGMLRNIRKNVFNLVLVVDALQPTARSVI 503
            |:|||..|:.|||::|.|.:|..||||:.:||||||||::|.||||:.|:|.:||....|...::
Human   450 AVDIRSPAISWVNNLEVDSRYNSWPSSLQELLRPTFPGVIRQIRKNLHNMVFIVDPAHETTAELM 514

  Fly   504 KLSESFVIHQAPIRLGLVFDARDANE-DNLADY-VAITCAYNYVSQKKDARAALSFLTDIYAAVG 566
            ..:|.|:.:..|:|:|.:|...|:.: |.:.|. ||:..|||||:|:.|...|...||.||..|.
Human   515 NTAEMFLSNHIPLRIGFIFVVNDSEDVDGMQDAGVAVLRAYNYVAQEVDDYHAFQTLTHIYNKVR 579

  Fly   567 ETKVVTKKDIVKQLTKEFTSLSFAKAEEFLEEDSTYDYGRELAAEFIQRLGFGDKGQPQALLNGV 631
            ..:.|..:.:|..|.|::   .:.:....|..||.||..|:.|..:.::.|.|.  .|..|.||:
Human   580 TGEKVKVEHVVSVLEKKY---PYVEVNSILGIDSAYDRNRKEARGYYEQTGVGP--LPVVLFNGM 639

  Fly   632 PMPSNVVTADSDFEEAIFTEIMTHTSNLQKAVYKGELTDNDVAIDYLMNQPHVMPRLNQRILSQE 696
            |.....:..| :.|.....:|:..|:..|:|||.|||..:...::|:||||:|:||:|.|||:.|
Human   640 PFEREQLDPD-ELETITMHKILETTTFFQRAVYLGELPHDQDVVEYIMNQPNVVPRINSRILTAE 703

  Fly   697 DVKYLDINGVAYKNLGNVGVLNRLSNRDMTATLMDNLKYF--GGKKSTELIGRASLQFLTIWVFA 759
            . .|||:.......:.:......|.::..||.:.:::.|.  .|..|.|:...:.::.:|.|:..
Human   704 R-DYLDLTASNNFFVDDYARFTILDSQGKTAAVANSMNYLTKKGMSSKEIYDDSFIRPVTFWIVG 767

  Fly   760 DLETDQGRDLLTHALDYVQSGESVRVAFIPNTESSSASSRRNLNRLVWAAMQSLPPTQATEQVLK 824
            |.::..||.||..|:.:.:|..:||::.|.|.....:.....::|.:|||:|:.....|...:.|
Human   768 DFDSPSGRQLLYDAIKHQKSSNNVRISMINNPAKEISYENTQISRAIWAALQTQTSNAAKNFITK 832

  Fly   825 WLKKP------------------------KEKIEIPTQLEDILGSTELHLKMLRVYSQRVLGLNK 865
            ..|:.                        ||..| .::::.||...        ||.:.||.|.|
Human   833 MAKEGAAEALAAGADIAEFSVGGMDFSLFKEVFE-SSKMDFILSHA--------VYCRDVLKLKK 888

  Fly   866 SQRLVIGNGRLYGPLSSDESFDSADFALLARFSSLQYSDKVRQVLKESAQD---------VNEEF 921
            .||.||.|||:.|||...|.|:..||.||...           :||.|.|.         |.|:.
Human   889 GQRAVISNGRIIGPLEDSELFNQDDFHLLENI-----------ILKTSGQKIKSHIQQLRVEEDV 942

  Fly   922 NSDTLLKLYASLLPRQTKTRFKLPTDLKTD-HSVVKLPPKQENLPHFDVAAVLDPASRAAQKLTP 985
            .||.::|:.| ||..|.|...::......| ||.:||.|| |...:|||.||:||.:|.||:|.|
Human   943 ASDLVMKVDA-LLSAQPKGDPRIEYQFFEDRHSAIKLRPK-EGETYFDVVAVVDPVTREAQRLAP 1005

  Fly   986 ILILLRQVLNCQLNLYLIPVPQHSDMPVKNFYRYVVEPEVQFEANGGRSDGPLAKFSGLPANPLL 1050
            :|::|.|::|..|.:::....:.||||:|:|||||:|||:.|.::...:.||:|||..:|.:||.
Human  1006 LLLVLAQLINMNLRVFMNCQSKLSDMPLKSFYRYVLEPEISFTSDNSFAKGPIAKFLDMPQSPLF 1070

  Fly  1051 TQQLQVPENWLVEAVRAVYDLDNIKLTDIGGPVHSEFDLEYLLLEGHCFDAASGAPPRGLQLVLG 1115
            |..|..||:|:||:||..||||||.|.::...|.:|::||||||||||:|..:|.||||||..||
Human  1071 TLNLNTPESWMVESVRTPYDLDNIYLEEVDSVVAAEYELEYLLLEGHCYDITTGQPPRGLQFTLG 1135

  Fly  1116 TQSQPTLVDTIVMANLGYFQLKANPGAWSLRLREGKSADIYAISHIEGTNTHHSAGSSEVQVLIT 1180
            |.:.|.:|||||||||||||||||||||.||||:|:|.|||.|...:||::...|  .||.:::.
Human  1136 TSANPVIVDTIVMANLGYFQLKANPGAWILRLRKGRSEDIYRIYSHDGTDSPPDA--DEVVIVLN 1198

  Fly  1181 SLRSHVVKLRVSKKPGMQQAELLSDDNEQAAQSGMWNSIASSFGGGSANQAATDEDTETINIFSV 1245
            :.:|.::|::|.||..|...:||||...: .:||.|:|....|.|....:...|:| :.||||||
Human  1199 NFKSKIIKVKVQKKADMVNEDLLSDGTSE-NESGFWDSFKWGFTGQKTEEVKQDKD-DIINIFSV 1261

  Fly  1246 ASGHLYERLLRIMMVSLLKHTKSPVKFWFLKNYLSPQFTDFLPHMASEYNFQYELVQYKWPRWLH 1310
            ||||||||.|||||:|:||:||:|||||||||||||.|.:|:|:||:||||||||||||||||||
Human  1262 ASGHLYERFLRIMMLSVLKNTKTPVKFWFLKNYLSPTFKEFIPYMANEYNFQYELVQYKWPRWLH 1326

  Fly  1311 QQTEKQRTIWGYKILFLDVLFPLNVRKIIFVDADAIVRTDIKELYDMDLGGAPYAYTPFCDSRKE 1375
            |||||||.|||||||||||||||.|.|.:|||||.|||||:|||.|.:|.||||.||||||||:|
Human  1327 QQTEKQRIIWGYKILFLDVLFPLVVDKFLFVDADQIVRTDLKELRDFNLDGAPYGYTPFCDSRRE 1391

  Fly  1376 MEGFRFWKQGYWRSHLMGRRYHISALYVVDLKRFRKIAAGDRLRGQYQALSQDPNSLSNLDQDLP 1440
            |:|:||||.|||.|||.||:||||||||||||:|||||||||||||||.||||||||||||||||
Human  1392 MDGYRFWKSGYWASHLAGRKYHISALYVVDLKKFRKIAAGDRLRGQYQGLSQDPNSLSNLDQDLP 1456

  Fly  1441 NNMIHQVAIKSLPDDWLWCQTWCSDSNFKTAKVIDLCNNPQTKEAKLTAAQRIVPEWKDYDAELK 1505
            |||||||.|||||.:||||:|||.|::.|.||.|||||||.|||.||.||.||||||:|||.|:|
Human  1457 NNMIHQVPIKSLPQEWLWCETWCDDASKKRAKTIDLCNNPMTKEPKLEAAVRIVPEWQDYDQEIK 1521

  Fly  1506 TLMSRIEDHENS 1517
            .|..|.:..:.:
Human  1522 QLQIRFQKEKET 1533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Uggt	NP_524151.2	UDP-g_GGTase	29..1196	CDD:283964	446/1218 (37%)
		RfaJ	1238..>1456	CDD:224359	181/217 (83%)
		GT8_HUGT1_C_like	1240..1487	CDD:133054	202/246 (82%)
UGGT1	NP_064505.1	UDP-g_GGTase	45..1202	CDD:283964	441/1207 (37%)
		Glucosyltransferase. /evidence=ECO:0000250	1244..1555		221/291 (76%)
		GT8_HUGT1_C_like	1256..1503	CDD:133054	202/246 (82%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1534..1555		687/1572 (44%)
		Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	1552..1555
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160069
Domainoid	1	1.000	472	1.000	Domainoid score	I451
eggNOG	1	0.900	-	-		E1_KOG1879
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10586
Inparanoid	1	1.050	1229	1.000	Inparanoid score	I187
Isobase	1	0.950	-	0	Normalized mean entropy	S3130
OMA	1	1.010	-	-		QHG55769
OrthoDB	1	1.010	-	-		D231263at2759
OrthoFinder	1	1.000	-	-		FOG0002023
OrthoInspector	1	1.000	-	-		otm40632
orthoMCL	1	0.900	-	-		OOG6_101176
Panther	1	1.100	-	-	O	PTHR11226
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2174
SonicParanoid	1	1.000	-	-		X1498
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750